Biological Studies on Memory and Hormones
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Questions and Answers

What was the primary variable being manipulated in the study?

  • Participant stress levels
  • Participant cortisol levels (correct)
  • Participant gender
  • Participant age
  • What was the main objective of the high cortisol group?

  • To investigate the impact of stress hormones on cognitive function
  • To investigate the effects of low cortisol levels on participants
  • To induce artificially high cortisol levels in participants (correct)
  • To assess the long-term effects of chronic stress
  • How long did each participant participate in the study?

  • One day
  • Four days (correct)
  • Seven days
  • Two days
  • What was the most likely reason for randomly allocating participants to different conditions?

    <p>To eliminate the possibility of individual differences between groups (D)</p> Signup and view all the answers

    What is an example of a potential confounding variable that the researchers might have considered?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the primary method used to measure brain activity in this study?

    <p>Functional Magnetic Resonance Imaging (fMRI) (B)</p> Signup and view all the answers

    What is the purpose of the training phase in this study?

    <p>To ensure participants are familiar with the joystick and task (D)</p> Signup and view all the answers

    What is the likely purpose of the six trials conducted in this study?

    <p>To assess changes in brain activity in response to different stimuli or tasks (D)</p> Signup and view all the answers

    What is the main focus of the research mentioned?

    <p>The impact of testosterone on risk-taking behavior (C)</p> Signup and view all the answers

    What is the expected outcome of the study?

    <p>Participants with higher testosterone levels will show increased risk-taking behavior. (D)</p> Signup and view all the answers

    What is a potential limitation of this study?

    <p>The use of fMRI may be sensitive to movement artifacts (B)</p> Signup and view all the answers

    Which of the following is NOT a potential application of this study's findings?

    <p>Measuring the effectiveness of different types of medications on brain activity (A)</p> Signup and view all the answers

    What type of study is most likely being conducted?

    <p>Experimental study (B)</p> Signup and view all the answers

    What is the independent variable in this study?

    <p>Testosterone levels (C)</p> Signup and view all the answers

    Which of the following statements accurately reflects the content provided?

    <p>Epigenetic modifications can influence an individual's vulnerability to stress. (B)</p> Signup and view all the answers

    What is the primary mechanism suggested for how epigenetic factors might influence stress vulnerability?

    <p>Modifying the expression of genes involved in stress hormone receptor production. (A)</p> Signup and view all the answers

    Which of the following scenarios BEST illustrates the concept described in the content?

    <p>Identical twins raised in different environments exhibit distinct levels of stress reactivity. (C)</p> Signup and view all the answers

    Based on the content, which of these could potentially contribute to individual differences in stress vulnerability?

    <p>Exposure to environmental stressors throughout life. (C)</p> Signup and view all the answers

    If a researcher were studying this topic, what would be a relevant research question based on the content?

    <p>Does methylation of stress hormone receptor genes differ between individuals with high and low stress levels? (A)</p> Signup and view all the answers

    What type of variable would 'patterns of methylation in gene sequences' be considered?

    <p>Independent Variable (B)</p> Signup and view all the answers

    In the stress response study, what is being used to assess the stress response?

    <p>Corticosterone levels in blood samples (A)</p> Signup and view all the answers

    Which of the following best describes the type of measurement used in the stress response study?

    <p>Quantitative measurement (C)</p> Signup and view all the answers

    Which of these is NOT a potential confounding variable in the stress response study?

    <p>The type of Plexiglass restrainer used (D)</p> Signup and view all the answers

    Why is it important to measure corticosterone levels before and after the restraint procedure?

    <p>To establish a baseline level of corticosterone for each rat (B)</p> Signup and view all the answers

    What was the relationship found between the 5-HTT gene and depression symptoms?

    <p>People with short alleles of the 5-HTT gene experienced more depression symptoms only when they were exposed to stressful life events. (C)</p> Signup and view all the answers

    What was the relationship between stress level and depression symptoms in participants with short alleles of the 5-HTT gene?

    <p>The higher the stress level, the greater the depression symptoms. (C)</p> Signup and view all the answers

    Which of the following is a plausible alternative explanation for the findings?

    <p>Stressful life events might directly influence the expression of the 5-HTT gene, leading to increased depression symptoms. (D)</p> Signup and view all the answers

    What can be concluded from the findings of this study?

    <p>Genetic predisposition plays a role in how an individual responds to stressful life events. (C)</p> Signup and view all the answers

    What is the most likely implication of these findings?

    <p>Further research is needed to understand the complex interplay between genetics, environment, and mental health. (B)</p> Signup and view all the answers

    Flashcards

    5-HTT gene

    A gene linked to serotonin transport and mood regulation.

    Short alleles

    Variations of the 5-HTT gene associated with mood disorders.

    Depression symptoms

    Signs indicating severe sadness or lack of interest in life.

    Stressful life events

    Challenging situations that can trigger emotional responses.

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    Gene-environment interaction

    How genes and environment influence mental health together.

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    Cortisol

    A hormone related to stress responses in the body.

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    High Cortisol Group

    Participants who received 160 mg of cortisol daily.

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    Random Allocation

    Participants are assigned to groups by chance.

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    Stress Mimicking

    Replicating conditions similar to high stress events.

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    Four-Day Procedure

    Duration of the study for participants' exposure.

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    Joystick training

    Participants learned to use a joystick for a specific task.

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    fMRI

    Functional Magnetic Resonance Imaging, a technique for measuring brain activity.

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    Six trials

    The number of attempts participants undertook during the study.

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    Brain activity measurement

    Monitoring brain responses while performing a task.

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    Task understanding

    Participants comprehended what was required of them in the exercise.

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    Testosterone's role

    Hormone hypothesized to influence risk-taking behavior.

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    Risk-taking behavior

    Actions that involve potential loss or danger.

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    Hypothesis in psychology

    A testable prediction about behavior and mental processes.

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    Greater risks

    Engaging in activities with higher chance of negative outcomes.

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    Behavioral study

    Research examining how actions are influenced by factors.

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    Genetic mapping technology

    A method to identify methylation patterns in genes.

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    Methylation

    The addition of a methyl group to DNA, affecting gene expression.

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    Corticosterone

    A hormone released during stress, measured in blood samples.

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    Plexiglass restrainer

    A clear container used to induce stress in rats for experiments.

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    Stress response measurement

    Assessing hormonal changes related to stress in experiments.

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    Epigenetic factors

    Elements that influence gene expression without altering DNA sequence, like methylation.

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    Stress hormone receptors

    Proteins that bind stress hormones, influencing body response to stress.

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    Vulnerability to stress

    A predisposition to react negatively to stressors, potentially influenced by genetics.

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    Gene methylation and stress

    The process by which methylation of genes may increase stress vulnerability.

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    Study Notes

    Biological Studies

    • Milner (1966) investigated the effects of removing HM's medial temporal lobe, including the hippocampus, on memory formation.
    • A longitudinal case study was used, utilising triangulation to gather data over several decades.
    • Data collection involved psychometric testing (IQ tests), direct observation of behavior, interviews with HM and family members, cognitive testing (memory recall and learning tasks), and MRI brain scans.
    • The hippocampus plays a crucial role in converting short-term memories into long-term memories, but it is not the location of permanent memory storage.

    Hormones and Pheromones

    • Newcomer et al (no date) investigated whether high levels of the stress hormone cortisol interfere with verbal declarative memory.
    • A double-blind, matched-pairs laboratory experiment was employed.
    • Participants were randomly allocated to one of three conditions (high cortisol, low cortisol, or placebo) for four days.
    • Participants recalled prose passages at baseline, after one day, after four days, and after a six-day follow-up.
    • High levels of cortisol impaired verbal declarative memory.
    • Memory performance in the high cortisol group returned to normal after stopping cortisol ingestion.

    The Relationship Between Genetics and Behaviour

    • Kendler used correlation to determine the likelihood of a significant relationship between two variables.
    • Kendler analysed a twin study (over 15,000 twins) from the Swedish national twin registry.
    • Heritability of depression estimated at 38% in monozygotic twins - females more influenced than men.
    • Caspi et al (2003) investigated whether a serotonin transporter gene mutation interacted with stressful life events to increase the risk of depression.
    • 847 New Zealand 26-year-olds completed a questionnaire about life events and were assessed for depression.
    • Participants with one or more short alleles of the 5-HTT gene showed more depression symptoms in response to stressful life events.

    Techniques Used to Study the Brain

    • Corkin (1997) analyzed HM's MRI scans to determine the extent of hippocampal and medial temporal lobe damage.
    • Two MRI scans were conducted on HM in 1992 and 1993.
    • MRI scans revealed that the lesioning of HM's brain was smaller than originally estimated, with damage to the uncus and amygdala, but about 50% of the posterior hippocampus remaining.
    • The remaining hippocampal tissue proved insufficient for normal memory function.

    Localization of Function

    • Localization of function is the theory that specific parts of the brain are responsible for specific behaviours or cognitive processes.
    • Neuroplasticity is the brain's ability to change and adapt in response to environmental demands.
    • Maguire et al (no date) investigated whether the brains of taxi drivers differed from those of non-taxi drivers due to the unique spatial demands of navigating a city.
    • Compared to non-taxi drivers, taxi drivers showed significantly larger posterior hippocampi.
    • This suggests adaptation of the hippocampus, especially the posterior region, in response to the environmental demands of spatial navigation.

    Neurotransmitters

    • Antonova et al (2011) investigated the effect of scopolamine, an acetylcholine antagonist, on hippocampal activity in spatial memory creation.
    • 20 healthy male adults participated in a scopolamine injection or placebo condition.
    • Participants were assessed using a virtual reality game in which they had to navigate an arena to find a pole.
    • Scopolamine significantly reduced hippocampal activation compared to the placebo condition.

    Cognitive Processing

    • Warrington and Shallice (no date) investigated the relationship between short-term memory (STM) and long-term memory (LTM) when STM is impaired.
    • Patient KF, after a motorcycle accident, showed impaired STM for verbal information.
    • He could, however, remember the same information visually.
    • This suggests separate verbal and visual memory stores.
    • Loftus and Palmer (no date) investigated how leading questions influence eyewitnesses' memories regarding car accidents.
    • Participants' estimates of speed increased when the question wording became more intense (e.g., "smashed" compared to "hit").
    • This shows that memory recall can be influenced by how a question is phrased.

    Flashbulb Memories

    • Neisser and Harsch (no date) focused on whether flashbulb memories are susceptible to distortion.
    • 106 Emory University students initially, with 44 returning for follow-up, filled out questionnaires about the Challenger disaster.
    • 2.5 years later, the same students filled out similar questionnaires and were interviewed.
    • There were significant discrepancies between initial recalled memories and later recollections.
    • High confidence in memories did not indicate accuracy.

    Emotion and Cognition

    • Sharot (no date) investigated the role of the amygdala in flashbulb memories.
    • 24 participants in New York City during the 9/11 attacks participated in an fMRI study.
    • Participants who were closer to the World Trade Center showed higher amygdala activation when recalling 9/11 memories compared to summer memories.

    Note-Taking Methods

    • Mueller and Oppenheimer (2014) investigated the effect of note-taking methods (longhand vs. laptop) on learning.
    • 109 undergraduate students took notes on lectures using either a laptop or pen and paper.
    • Participants in the longhand condition performed better on factual questions.

    Social Cognitive Theory

    • Bandura's social cognitive theory emphasizes learning through observation and imitation, including aggressive behaviors; 72 children participated.
    • Children exposed to aggressive models exhibited significantly more aggression than those in non-aggressive groups.
    • Boys more influenced by same-sex models (particularly for physical aggression), and girls more influenced by same-sex models (for verbal aggression), despite some males exhibiting more verbal aggression.

    Stereotypes

    • Hamilton and Gifford (no date) studied how the distinctiveness of a minority group influences the formation of illusory correlations.
    • Undergraduates were asked to consider hypothetical groups, in which the minority group was more likely to be described as engaging in negative behaviours.
    • People rated the minority group worse than the majority group even though the groups exhibited the same ratio of positive to negative behaviour.
    • Steele and Aronson (1995) examined the effect of stereotype threat on test performance.

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    Description

    Explore the fascinating research surrounding memory formation and the impact of hormones on cognitive function. Delve into the case study of HM and the effects of cortisol on verbal memory. This quiz covers critical findings and methodologies used in understanding the brain's role in memory processing.

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