Biological Networks Quiz
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Questions and Answers

What is a key feature of scale-free networks?

  • Small-world effect due to hubs (correct)
  • Linear path lengths
  • Hierarchical structure
  • Random degree distributions
  • Why is identifying interactions or correlations important in causality?

  • To introduce hierarchical models
  • To increase network sparsification
  • To establish a causal mechanism (correct)
  • To create random networks
  • How can outside knowledge contribute to network sparsification?

  • Introduce irrelevant interactions
  • Increase indirect correlations
  • Aid in extracting most likely subnetworks (correct)
  • Lead to false positives
  • What does the onion structure in networks allow for?

    <p>Multi-level responses</p> Signup and view all the answers

    In protein modeling, what is the significance of learning amino acid codes?

    <p>Learning binding preferences of different proteins</p> Signup and view all the answers

    Why do scale-free networks create a small-world effect?

    <p>Presence of hubs reducing path lengths</p> Signup and view all the answers

    What type of interactions involve stable interactions such as ribosomes, proteasome, and respiratory chain complexes?

    <p>Protein-protein stable interactions</p> Signup and view all the answers

    Which centrality measure refers to the number of shortest paths that use a node in a network?

    <p>Betweenness centrality</p> Signup and view all the answers

    What type of network analysis measure is most commonly used for guilt-by-association analyses like predicting proteins as cancer drivers?

    <p>Degree centrality</p> Signup and view all the answers

    In network analysis, what does network density refer to?

    <p>The number of edges compared to the maximum possible edges</p> Signup and view all the answers

    Which type of network interaction involves post-translational modifications and steric hindrance?

    <p>Protein-protein transient interactions</p> Signup and view all the answers

    What is the reciprocal of the average shortest path distance to all other nodes in a network called?

    <p>Closeness centrality</p> Signup and view all the answers

    How does network centrality influence gene retention or loss?

    <p>Influences evolutionary retention or loss</p> Signup and view all the answers

    What impact does alternative splicing have on interactome complexity?

    <p>Increases interactome complexity</p> Signup and view all the answers

    How do Mendelian disease mutations impact protein-protein interactions (PPIs)?

    <p>Lead to variations in disease severity</p> Signup and view all the answers

    What contributes to organismal complexity and functional diversity according to the text?

    <p>Alternative splicing</p> Signup and view all the answers

    How can the effects of mutations on disease be predicted according to the text?

    <p>Using in-silico methods incorporating structural and network data</p> Signup and view all the answers

    What does alternative splicing reveal within a network, according to the text?

    <p>Deeper modularity and isoform-level resolution</p> Signup and view all the answers

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