L25 MCQ - Biogenic Amines and Neurotransmitters Quiz

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which enzyme is responsible for the degradation of dopamine in the synaptic cleft?

COMT

UPS

MAO (correct)

Which of the following diseases is associated with insufficient dopamine in the nigrostriatal pathway?

Tourette syndrome

Attention deficit hyperactivity disorder

Parkinson's disease (correct)

Schizophrenia

What is the main neurotransmitter involved in motor control?

Acetylcholine

Dopamine (correct)

GABA

Serotonin

What is the role of the substantia nigra in motor control?

Stimulates release of dopamine (B) Signup and view all the answers

What is the main cause of the loss of pigmentation in the substantia nigra in Parkinson's disease?

Environmental toxins (D) Signup and view all the answers

Which of the following is a common treatment for Parkinson's disease that enhances dopamine signaling?

Levodopa (D) Signup and view all the answers

What was covered in Lecture 1?

CNS neurotransmission (B) Signup and view all the answers

What is the role of COMT in dopamine degradation?

Transfers methyl groups to hydroxyl group of catechols (C) Signup and view all the answers

What are Lewy bodies?

Protein aggregates in Parkinson's disease (B) Signup and view all the answers

What are the sites of action of common treatments for Parkinson's disease?

DA receptors (C) Signup and view all the answers

Which of the following is true about biogenic amines?

They are derived from tyrosine and part of the same biosynthetic pathway (C) Signup and view all the answers

What is the role of tyrosine hydroxylase?

It controls the rate limiting step in the biosynthetic pathway (D) Signup and view all the answers

Which transporter is responsible for the uptake and storage of catecholamines and indoleamines?

Vesicular monoamine transporter (VMAT) (A) Signup and view all the answers

What is the role of reserpine in neurotransmission?

It inhibits the uptake of biogenic amines into vesicles (B) Signup and view all the answers

Which receptors are coupled to G proteins in dopamine neurotransmission?

D1-D5 (B) Signup and view all the answers

What is the effect of D1-like receptors on adenylate cyclase activity?

Activation (increases cAMP) (C) Signup and view all the answers

Where are vesicles containing dopamine β-hydroxylase (DBH) found?

Chromaffin granules (C) Signup and view all the answers

Which of the following is NOT true about tyrosine?

It is a neurotransmitter (A) Signup and view all the answers

What is the role of catecholamines in the body?

They function as both systemic hormones and neurotransmitters (D) Signup and view all the answers

What is the diagnostic marker for catecholaminergic cells?

Tyrosine hydroxylase (A) Signup and view all the answers

Study Notes

Dopamine and Motor Control

The enzyme COMT is responsible for the degradation of dopamine in the synaptic cleft.
Insufficient dopamine in the nigrostriatal pathway is associated with Parkinson's disease.

Neurotransmitters and Enzymes

Dopamine is the main neurotransmitter involved in motor control.
Tyrosine hydroxylase is the enzyme responsible for converting tyrosine into L-DOPA, a precursor to dopamine.

Substantia Nigra and Parkinson's Disease

The substantia nigra is involved in motor control and is affected in Parkinson's disease.
The loss of pigmentation in the substantia nigra in Parkinson's disease is due to the death of dopaminergic neurons.

Treatments for Parkinson's Disease

Dopamine Enhancers, such as L-DOPA, are a common treatment for Parkinson's disease that enhance dopamine signaling.
Reserpine, a drug that depletes catecholamine stores, has an opposite effect on dopamine signaling.

Biogenic Amines and Neurotransmission

Biogenic amines, including dopamine, norepinephrine, and serotonin, are synthesized from amino acids.
Vesicles containing dopamine β-hydroxylase (DBH) are found in postganglionic neurons of the sympathetic nervous system.
The VMAT (vesicular monoamine transporter) is responsible for the uptake and storage of catecholamines and indoleamines.
D1-like receptors are coupled to G proteins and increase adenylate cyclase activity when stimulated.

Catecholamines and Lewy Bodies

Catecholamines, including dopamine, norepinephrine, and epinephrine, are involved in various bodily functions, such as motor control and stress response.
Lewy bodies are abnormal protein clumps found in catecholaminergic cells and are a hallmark of Parkinson's disease.
Tyrosine is not converted into L-DOPA by tyrosine hydroxylase in the absence of a cofactor.

Diagnostic Markers

The presence of TH-positive neurons is a diagnostic marker for catecholaminergic cells.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Description

Test your knowledge on biogenic amines, bioactive amine neurotransmitters implicated in various behaviors such as movement, reward, addiction, depression, and sleep. Learn about the catecholamines and their role as neurotransmitters like dopamine and norepinephrine. Explore the pharmacological drugs that affect their neurotransmission.