Biochemistry: Pyruvate to Acetyl CoA
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Questions and Answers

What is the name of the molecule that is produced when pyruvate is converted to acetyl CoA?

  • Coenzyme A
  • Carbon dioxide
  • Pyruvate
  • Acetyl CoA (correct)
  • What is the function of the pyruvate dehydrogenase complex?

  • To generate ATP
  • To convert pyruvate to acetyl CoA (correct)
  • To transport pyruvate into the mitochondrion
  • To break down glucose into pyruvate
  • How many molecules of CO2 are produced per molecule of pyruvate during the conversion of pyruvate to acetyl CoA?

  • 3
  • 1 (correct)
  • 2
  • 4
  • Why is the carboxyl group (--COO-) of pyruvate removed during the conversion of pyruvate to acetyl CoA?

    <p>Because it has little chemical energy (A)</p> Signup and view all the answers

    What is the role of the transport protein in the conversion of pyruvate to acetyl CoA?

    <p>To carry pyruvate across the mitochondrial membrane (C)</p> Signup and view all the answers

    What happens to the α-ketoglutarate molecule during the reaction catalyzed by α-ketoglutarate dehydrogenase?

    <p>It is oxidized, losing electrons to NAD+. (D)</p> Signup and view all the answers

    What is the fate of the CO2 produced during the conversion of pyruvate to acetyl CoA?

    <p>It diffuses out of the cell (C)</p> Signup and view all the answers

    Which of the following molecules is directly involved in the conversion of α-ketoglutarate to succinyl-CoA?

    <p>Coenzyme A (A)</p> Signup and view all the answers

    Where does the conversion of pyruvate to acetyl CoA occur?

    <p>Mitochondrial matrix (C)</p> Signup and view all the answers

    What is the role of NAD+ in the conversion of α-ketoglutarate to succinyl-CoA?

    <p>It accepts electrons from α-ketoglutarate, becoming reduced to NADH. (D)</p> Signup and view all the answers

    What is the name of the process that converts glucose to pyruvate?

    <p>Glycolysis (D)</p> Signup and view all the answers

    Which of the following statements accurately describes the bond formed between succinyl-CoA and coenzyme A?

    <p>The bond is a high-energy, unstable thioester bond. (D)</p> Signup and view all the answers

    What is the significance of the unstable bond formed between succinyl-CoA and coenzyme A?

    <p>It allows the molecule to easily transfer its energy to other molecules. (D)</p> Signup and view all the answers

    What is the name of the enzyme that catalyzes the reaction between acetyl CoA and oxaloacetate?

    <p>Citrate synthase (A)</p> Signup and view all the answers

    Which of the following molecules is a product of the reaction between acetyl CoA and oxaloacetate?

    <p>Citrate (A)</p> Signup and view all the answers

    What is the function of CoA in the reaction shown above?

    <p>It carries the acetyl group to the reaction. (B)</p> Signup and view all the answers

    What is the net change in the number of carbon atoms during the formation of citrate from acetyl CoA and oxaloacetate?

    <p>An increase of two carbon atoms. (D)</p> Signup and view all the answers

    Which of the following statements accurately describes the role of oxaloacetate in the citric acid cycle?

    <p>It is the starting molecule for the cycle. (D)</p> Signup and view all the answers

    Which of the following is NOT a product of the Krebs cycle?

    <p>Pyruvate (A)</p> Signup and view all the answers

    What is the net ATP production from the Krebs cycle per molecule of glucose?

    <p>2 (B)</p> Signup and view all the answers

    What is the role of the electron transport chain in cellular respiration?

    <p>To create a proton gradient across the mitochondrial membrane. (C)</p> Signup and view all the answers

    Which of the following statements about the Krebs cycle is TRUE?

    <p>It is a series of enzyme-catalyzed reactions. (C)</p> Signup and view all the answers

    Which of these is another name for the Krebs Cycle?

    <p>Citric Acid Cycle (C)</p> Signup and view all the answers

    What is the name of the molecule that combines with oxaloacetate to initiate the Krebs cycle?

    <p>Acetyl CoA (C)</p> Signup and view all the answers

    What is the main purpose of the Krebs cycle in cellular respiration?

    <p>All of the above. (D)</p> Signup and view all the answers

    In what part of the cell does the Krebs cycle occur?

    <p>Mitochondrial Matrix (D)</p> Signup and view all the answers

    What is the role of oxygen in the Krebs cycle?

    <p>To act as the final electron acceptor in the electron transport chain. (C)</p> Signup and view all the answers

    Which of the following is NOT a product of glycolysis?

    <p>FADH2 (C)</p> Signup and view all the answers

    Which of the following molecules releases electrons into the electron transport chain (ETC) to produce ATP?

    <p>NADH (B)</p> Signup and view all the answers

    How many ATP molecules are produced from the oxidation of one NADH molecule in the ETC?

    <p>3 (C)</p> Signup and view all the answers

    What is the primary function of the electron transport chain (ETC)?

    <p>To produce ATP from ADP and inorganic phosphate. (C)</p> Signup and view all the answers

    Where in the mitochondria does the electron transport chain take place?

    <p>Inner membrane (D)</p> Signup and view all the answers

    What is the role of ATP synthase in the ETC?

    <p>To generate ATP from ADP and inorganic phosphate. (B)</p> Signup and view all the answers

    What is the driving force for the movement of protons across the inner mitochondrial membrane in chemiosmosis?

    <p>All of the above. (D)</p> Signup and view all the answers

    Where in the mitochondria does the proton gradient form during oxidative phosphorylation?

    <p>Intermembrane space (A)</p> Signup and view all the answers

    What is the final electron acceptor in the electron transport chain?

    <p>Oxygen (D)</p> Signup and view all the answers

    Which of the following is NOT a protein complex involved in the electron transport chain?

    <p>Ubiquinone dehydrogenase complex (C)</p> Signup and view all the answers

    Where does the electron transport chain take place?

    <p>Inner mitochondrial membrane (C)</p> Signup and view all the answers

    What is the role of ubiquinone (Q) in the electron transport chain?

    <p>To transport electrons from NADH dehydrogenase complex to cytochrome bc1 complex (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the electron transport chain?

    <p>It directly produces glucose from pyruvate (A)</p> Signup and view all the answers

    What is the primary purpose of the proton gradient generated by the electron transport chain?

    <p>To drive the synthesis of ATP (A)</p> Signup and view all the answers

    How does the electron transport chain contribute to the overall energy yield of cellular respiration?

    <p>It harnesses the energy released from electron movement to produce a proton gradient that drives ATP synthesis (C)</p> Signup and view all the answers

    What would happen to ATP production in the absence of oxygen?

    <p>ATP production would decrease significantly (B)</p> Signup and view all the answers

    Which of the following is NOT true about cytochrome c in the electron transport chain?

    <p>It acts as a catalyst for ATP synthesis (C)</p> Signup and view all the answers

    Flashcards

    Acetyl CoA

    A molecule that carries an acetyl group to the citric acid cycle.

    Oxaloacetate

    A four-carbon molecule that combines with Acetyl CoA to form citrate.

    Citrate

    The six-carbon product formed from the reaction of Acetyl CoA and oxaloacetate.

    Citrate synthase

    The enzyme that facilitates the conversion of oxaloacetate and Acetyl CoA into citrate.

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    Citric Acid Cycle

    A series of chemical reactions used by all aerobic organisms to generate energy.

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    Succinyl-CoA

    A compound formed during the citric acid cycle when an unstable molecule attaches to coenzyme A.

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    α-Ketoglutarate

    A key intermediate in the citric acid cycle, derived from isocitrate after losing CO2.

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    NADH

    A reduced form of NAD+, generated during oxidative reactions in the citric acid cycle.

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    Coenzyme A

    A cofactor involved in the synthesis and oxidation of fatty acids and the citric acid cycle.

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    Oxidative Decarboxylation

    The process where a molecule loses CO2 and is oxidized, producing NADH in the citric acid cycle.

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    E3 enzymes

    A group of 12 enzymes involved in transferring ubiquitin to proteins.

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    Pyruvate

    A product of glycolysis that enters the mitochondria; it transforms into acetyl CoA.

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    Transport protein

    A protein needed for the active transport of pyruvate into mitochondria.

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    Krebs cycle

    A series of chemical reactions used by all aerobic organisms to generate energy.

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    Dehydration reaction

    A chemical reaction that involves the removal of water; occurs during the formation of acetyl CoA.

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    Carbon dioxide release

    The first step of cellular respiration when pyruvate loses a carboxyl group as CO2.

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    Multi-enzyme complex

    A structure composed of several enzymes working together, e.g., pyruvate dehydrogenase complex.

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    Cellular Energy Harvest

    The process by which cells extract energy from nutrients.

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    Glycolysis

    The breakdown of glucose into pyruvate, producing small amounts of ATP and NADH.

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    Electron Transport Chain

    A series of protein complexes that transfer electrons to produce ATP.

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    ATP Synthesis

    The production of ATP from ADP and inorganic phosphate using energy.

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    Oxidation of Pyruvate

    The conversion of pyruvate to acetyl-CoA, linking glycolysis to the Krebs cycle.

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    Mobile Carriers

    Molecules that transport electrons and protons in the electron transport chain.

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    Free Energy (G)

    The energy available to perform work in biological systems.

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    Uncontrolled Reaction vs Cellular Respiration

    Comparing energy release during explosions vs controlled ATP generation from food.

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    Cellular Respiration

    The process by which cells break down glucose to produce energy.

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    Products of Krebs Cycle

    Produces 2 ATP, 6 NADH, 6 H+, and 2 FADH2 per glucose.

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    Decarboxylation

    The removal of carbon dioxide from a compound during the Krebs Cycle.

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    Enzyme-Catalyzed Reactions

    Speeding up reactions in the Krebs cycle through enzymes.

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    NADH and FADH2

    Energy carriers produced in the Krebs Cycle, used in the Electron Transport Chain.

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    Link Reaction

    The step connecting glycolysis to the Krebs cycle involving the conversion of pyruvate.

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    Total Energy Yield

    Total output from one glucose: 4 ATP, 10 NADH, and 2 FADH2.

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    Electron Transport Chain (ETC)

    A series of proteins that transfer electrons, leading to ATP production.

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    NADH produced ATP

    1 NADH contributes to the formation of 3 ATP in the ETC.

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    FADH2 produced ATP

    1 FADH2 contributes to the formation of 2 ATP in the ETC.

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    Total ATP from Glycolysis

    From 10 NADH and 2 FADH2, a total of 34 ATP is produced in ETC.

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    Chemiosmosis

    The process where ATP is synthesized using the H+ gradient created by the ETC.

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    Proton gradient

    A difference in H+ concentration across the inner membrane, vital for ATP production.

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    ATP Synthase

    An enzyme that uses the proton gradient to produce ATP from ADP and Pi.

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    End product of ATP synthesis

    ATP is produced using ADP and inorganic phosphate (Pi) via chemiosmosis.

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