Biochemistry of Lipids and Fatty Acids
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Questions and Answers

What is the significance of the omega carbon in fatty acids?

  • It defines the length of the fatty acid chain.
  • It denotes the last carbon in the hydrocarbon chain. (correct)
  • It is the site for the addition of hydrogen atoms.
  • It indicates the position of double bonds in the fatty acid.

Which of the following fatty acids is considered an omega-3 fatty acid?

  • Stearic acid
  • Palmitic acid
  • Alpha-linolenic acid (correct)
  • Linoleic acid

How does the presence of double bonds in fatty acids relate to rancidity?

  • Decreases vulnerability to spoiling.
  • Increases stability against oxidation.
  • Increases susceptibility to oxidation and rancidity. (correct)
  • Leads to a slower rate of rancidity.

What is a primary cardioprotective effect of omega-3 fatty acids?

<p>Decreased risk of cardiovascular disease. (D)</p> Signup and view all the answers

Which type of fat is more likely to lead to increased LDL cholesterol levels?

<p>Trans fats (D)</p> Signup and view all the answers

What happens to vegetable oils during the process of hydrogenation?

<p>They are solidified and converted to solid fats. (C)</p> Signup and view all the answers

Which of the following statements accurately describes trans fats?

<p>They are chemically identical to saturated fats. (B)</p> Signup and view all the answers

Which food item is least likely to contain trans fats?

<p>Fruits and vegetables (C)</p> Signup and view all the answers

Which fatty acid is classified as omega-3?

<p>Linolenic acid (B)</p> Signup and view all the answers

What is the main dietary source of arachidonic acid?

<p>Linoleic acid (C)</p> Signup and view all the answers

Which of the following statements about the physical properties of fatty acids is correct?

<p>Melting temperature increases for saturated fatty acids with longer carbon chains. (D)</p> Signup and view all the answers

Which fatty acid has the formula $CH_3(CH_2)_7CH=CH(CH_2)_7COOH$?

<p>Palmitoleic acid (D)</p> Signup and view all the answers

Which of the following fatty acids is NOT considered essential?

<p>Palmitic acid (A)</p> Signup and view all the answers

How does an increase in the number of double bonds in unsaturated fatty acids affect their solubility?

<p>It increases solubility. (D)</p> Signup and view all the answers

What effect does rancidity have on fatty acids?

<p>It results in the formation of free radicals. (B)</p> Signup and view all the answers

Which of the following does NOT describe a property of saturated fatty acids?

<p>They contain one or more double bonds. (A)</p> Signup and view all the answers

Which statement accurately describes the properties of saturated and unsaturated fatty acids?

<p>Saturated fatty acids generally have higher melting points compared to unsaturated fatty acids. (A)</p> Signup and view all the answers

Which type of fatty acid is considered essential and must be obtained through diet?

<p>Polyunsaturated fatty acids (A)</p> Signup and view all the answers

What effect do omega-3 fatty acids have on cardiovascular health?

<p>They have a cardioprotective effect and reduce the risk of heart diseases. (C)</p> Signup and view all the answers

Which of the following is most likely to lead to rancidity in fatty acids?

<p>Oxidation due to light and air exposure (C)</p> Signup and view all the answers

How are saturated and unsaturated fatty acids classified based on their carbon double bond structure?

<p>Saturated fatty acids have no double bonds, while monounsaturated contain one and polyunsaturated contain two or more. (D)</p> Signup and view all the answers

What characteristic do unsaturated fatty acids typically have due to their molecular structure?

<p>A kink in the chain due to cis double bonds (C)</p> Signup and view all the answers

In terms of calorie yield from fatty acids, how does it compare to carbohydrates and proteins?

<p>Fat yields more than double the calories per gram compared to carbohydrates. (B)</p> Signup and view all the answers

Which of the following compounds can be synthesized from saturated fatty acids in the liver?

<p>Cholesterol (B)</p> Signup and view all the answers

Which fatty acid is produced as a result of hydrogenation of oleic acid?

<p>Stearic acid (A)</p> Signup and view all the answers

What dietary source is rich in omega-3 fatty acids?

<p>Salmon (B)</p> Signup and view all the answers

Which statement regarding the relative stability of fatty acids is accurate?

<p>Unsaturated fatty acids with multiple double bonds are less stable than those with fewer double bonds. (B)</p> Signup and view all the answers

Which type of fatty acid is synthesized from the partial hydrogenation process?

<p>Trans fats (C)</p> Signup and view all the answers

Which food is most likely to contain trans fats?

<p>Fried chicken (C)</p> Signup and view all the answers

Which fatty acid would not typically contribute to an increase in serum triglycerides?

<p>Omega-3 fatty acids (A)</p> Signup and view all the answers

Which of the following statements about the health impacts of trans fats is correct?

<p>Trans fats raise LDL cholesterol levels. (A)</p> Signup and view all the answers

Which fatty acid is characterized as omega-6 and is often consumed in diets?

<p>Linoleic acid (C)</p> Signup and view all the answers

Which fatty acid is classified as a saturated fatty acid with 18 carbon atoms?

<p>Stearic acid (A)</p> Signup and view all the answers

Which of the following unsaturated fatty acids has the highest number of double bonds?

<p>Linolenic acid (D)</p> Signup and view all the answers

Which statement accurately describes the relationship between chain length and melting temperature in saturated fatty acids?

<p>Melting temperature increases with increasing chain length. (C)</p> Signup and view all the answers

What is the structural formula for oleic acid?

<p>$CH_3(CH_2)_7CH=CH(CH_2)_7COOH$ (B)</p> Signup and view all the answers

Which fatty acid must be obtained through diet and is classified as omega-6?

<p>Linoleic acid (D)</p> Signup and view all the answers

What effect does increasing the number of double bonds in unsaturated fatty acids have on their melting points?

<p>Melting points decrease. (D)</p> Signup and view all the answers

Which of the following fatty acids contains three double bonds and is essential in the diet?

<p>Linolenic acid (C)</p> Signup and view all the answers

Which fatty acid would you classify as having a 16-carbon chain and one double bond?

<p>Palmitoleic acid (A)</p> Signup and view all the answers

What is the primary structural difference between saturated and unsaturated fatty acids?

<p>Saturated fatty acids have no double bonds. (D)</p> Signup and view all the answers

Which type of fatty acid is likely to contain more than one double bond?

<p>Polyunsaturated fatty acid (B)</p> Signup and view all the answers

What is a common clinical consequence associated with high consumption of saturated fatty acids?

<p>Increased levels of LDL cholesterol (A)</p> Signup and view all the answers

Which of the following best describes a cis double bond in fatty acids?

<p>It results in a kink in the fatty acid chain. (A)</p> Signup and view all the answers

Which food source is most likely to contain high levels of saturated fatty acids?

<p>Butter (B)</p> Signup and view all the answers

Which of the following fatty acids is classified as monounsaturated?

<p>Oleic acid (D)</p> Signup and view all the answers

What impact do polyunsaturated fatty acids have on diabetes mellitus type 2?

<p>They reduce the risk of developing the disease. (D)</p> Signup and view all the answers

Which statement about the calorie yield from fatty acids compared to carbohydrates and proteins is correct?

<p>Fatty acids yield more energy per gram than carbohydrates. (B)</p> Signup and view all the answers

Which of the following food categories is least likely to contain high levels of omega-3 fatty acids?

<p>Red meat (C)</p> Signup and view all the answers

Which fatty acid is most likely to increase serum triglyceride levels due to dietary intake?

<p>Elaidic acid (D)</p> Signup and view all the answers

What is a characteristic of polyunsaturated fatty acids (PUFAs) in relation to rancidity?

<p>More susceptible to oxidation than saturated fatty acids (B)</p> Signup and view all the answers

Which type of fatty acid is characterized by the presence of at least one cis double bond?

<p>Monounsaturated fatty acid (A)</p> Signup and view all the answers

Which of the following components primarily contributes to the formation of trans fats during food processing?

<p>Partial hydrogenation of unsaturated fats (C)</p> Signup and view all the answers

Which of the following is a typical industrial use of hydrogenated vegetable oils?

<p>Making margarine (B)</p> Signup and view all the answers

What is a common dietary source for obtaining linoleic acid, an omega-6 fatty acid?

<p>Safflower oil (C)</p> Signup and view all the answers

Which effect is commonly observed with high consumption of trans fats compared to unsaturated fats?

<p>Increase in cardiovascular disease risk (B)</p> Signup and view all the answers

Which fatty acid has three double bonds and is essential in the human diet?

<p>Linolenic acid (A)</p> Signup and view all the answers

Which of the following fatty acids is classified as a saturated fatty acid with 16 carbon atoms?

<p>Palmitic acid (B)</p> Signup and view all the answers

What effect does increasing the number of double bonds in unsaturated fatty acids generally have on their melting points?

<p>Decreases melting point (B)</p> Signup and view all the answers

Which unsaturated fatty acid has two double bonds and is an essential fatty acid?

<p>Linoleic acid (C)</p> Signup and view all the answers

Which of the following is true regarding the solubility of fatty acids?

<p>Decreases with chain length (B)</p> Signup and view all the answers

Which fatty acid is classified as an omega-6 fatty acid and is often consumed in diets?

<p>Linoleic acid (D)</p> Signup and view all the answers

What is the structural formula for the saturated fatty acid stearic acid?

<p>$CH_3(CH_2)_{16}CO_2H$ (C)</p> Signup and view all the answers

Which of the following explains why unsaturated fatty acids are often more soluble in water than saturated fatty acids?

<p>Presence of double bonds (A)</p> Signup and view all the answers

What structural feature primarily distinguishes saturated fatty acids from unsaturated fatty acids?

<p>Absence of double bonds (A)</p> Signup and view all the answers

Which dietary source is most closely associated with high levels of saturated fatty acids?

<p>Butter (D)</p> Signup and view all the answers

What is the primary effect of polyunsaturated fatty acids on cardiovascular health?

<p>Reduction of triglyceride levels (A)</p> Signup and view all the answers

Which type of fatty acid typically contains only one double bond?

<p>Monounsaturated fatty acid (A)</p> Signup and view all the answers

Which of the following is NOT a function of fatty acids in the body?

<p>Building blocks of protein synthesis (C)</p> Signup and view all the answers

How are polyunsaturated fatty acids classified based on their chemical structure?

<p>Presence of three or more double bonds (D)</p> Signup and view all the answers

Which factor can increase the risk of diseases such as atherosclerosis and obesity?

<p>High intake of saturated fatty acids (B)</p> Signup and view all the answers

Which of the following statements about unsaturated fatty acids is correct?

<p>They can exist in both cis and trans configurations. (D)</p> Signup and view all the answers

Flashcards

Omega Carbon

The carbon atom at the end of a fatty acid's methyl group.

Omega-3 Fatty Acids

Fatty acids with a double bond on the third carbon from the omega end.

Rancidity

Spoiling of fats through oxidation.

Hydrogenation

Adding hydrogen to unsaturated fatty acids to make them saturated.

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Trans Fat

Unsaturated fats that behave like saturated fats, created by partial hydrogenation.

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Cis-Trans Fatty Acids

Different arrangements of double bonds in unsaturated fatty acids.

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Bad Fats

Trans fats that negatively impact cholesterol levels and increase risk of heart diseases.

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Hydrogenation of Vegetable Oils

Industrial process of saturating vegetable oils to form solid fats like vanaspati ghee

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Saturated Fatty Acids

Fatty acids with no double bonds between carbon atoms.

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Unsaturated Fatty Acids

Fatty acids with at least one double bond between carbon atoms.

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Palmitic Acid

A saturated fatty acid with 16 carbon atoms.

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Oleic Acid

A monounsaturated fatty acid with 18 carbon atoms and one double bond.

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Linoleic Acid

A polyunsaturated fatty acid with 18 carbon atoms and two double bonds.

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Linolenic Acid

A polyunsaturated fatty acid with 18 carbon atoms and three double bonds.

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Essential Fatty Acids

Fatty acids our bodies cannot produce and must be obtained from diet.

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Melting Point of Fatty Acids

The temperature at which a fatty acid changes from solid to liquid state.

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Fatty Acid Building Block

Fatty acids are the basic components of lipids.

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Monounsaturated Fatty Acid

A fatty acid with one double bond.

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Polyunsaturated Fatty Acid

A fatty acid with more than one double bond.

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Lipid Solubility

Lipids are insoluble in water, soluble in organic solvents.

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Lipid Energy Content

9 calories per gram.

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Clinical Significance of Fatty Acids

Fatty acids play a role in obesity, heart disease, and other conditions.

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Cardioprotective Effects of Omega-3 Fatty Acids

Omega-3 fatty acids have been shown to reduce the risk of cardiovascular disease and lower serum triglycerides.

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What are some foods that contain trans fat?

Processed foods like baked goods, shortening, microwave popcorn, frozen pizza, fried foods, and nondairy coffee creamer are sources of trans fats.

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How do trans fats affect your health?

Trans fats raise bad cholesterol (LDL) and lower good cholesterol (HDL), increasing the risk of heart disease and stroke.

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What are the most common fatty acids in humans?

The most common fatty acids found in the human body have 16 or 18 carbon atoms in their chain. These can be saturated or unsaturated.

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What's the difference between palmitic and stearic acid?

Palmitic and stearic acids are both saturated fatty acids, but palmitic has 16 carbons and stearic has 18.

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What's unique about linolenic acid?

Linolenic acid is an 18-carbon polyunsaturated fatty acid with three double bonds. It's an essential fatty acid.

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How does chain length affect fatty acid melting point?

Saturated fatty acids have a higher melting point with increasing chain length. This is because longer chains have more intermolecular forces.

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What happens to melting point with more double bonds?

Unsaturated fatty acids have a lower melting point with more double bonds. Double bonds create kinks, reducing intermolecular forces.

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Name two essential fatty acids.

Linoleic acid (omega 6, 18:2) and linolenic acid (omega 3, 18:3) are essential fatty acids. Our bodies cannot produce them, so we need to get them from our diet.

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What's the relationship between linoleic and arachidonic acids?

Arachidonic acid is formed from linoleic acid in the body. Both are polyunsaturated fatty acids.

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What is the nomenclature of fatty acids based on?

Fatty acid nomenclature is based on the number of carbon atoms in the chain and the number and position of double bonds.

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What are lipids?

Lipids are a group of organic compounds that include fats, oils, waxes, steroids, and other molecules that are insoluble in water but soluble in organic solvents like ether, benzene, acetone, and chloroform.

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Amphipathic Nature of Fatty Acids

Fatty acids are amphipathic, meaning they have both a polar (water-loving) head group and an apolar (water-hating) hydrocarbon tail.

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Micelle Formation

In water, fatty acids arrange themselves into micelles, where the polar head groups face outward towards the water, and the nonpolar tails cluster together inside.

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What is the difference between saturated and unsaturated fats?

Saturated fats have no double bonds between carbon atoms, making them straight and solid at room temperature. Unsaturated fats have at least one double bond, causing them to be bent and liquid at room temperature.

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Clinical Implications of Fatty Acids

Fatty acids play a crucial role in various health conditions. Saturated fats contribute to obesity, heart disease, atherosclerosis, diabetes mellitus type 2, certain cancers, and stroke.

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Cardioprotective Effects

Omega-3 fatty acids reduce the risk of heart disease and lower triglycerides.

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What are Fatty Acids?

Fatty acids are the building blocks of lipids. They come in two main types: saturated and unsaturated, depending on their structure.

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Saturated vs. Unsaturated

Saturated fatty acids have no double bonds between carbon atoms, making them straight and solid at room temperature. Unsaturated have at least one double bond, creating kinks and making them liquid.

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What are Essential Fatty Acids?

Essential fatty acids are those our bodies can't make, so we must get them from food. Examples are linoleic and linolenic acid.

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What are Micelles?

Micelles are spherical structures formed by fatty acids in water. The polar heads face outward towards the water, while the nonpolar tails cluster inside.

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Why are Essential Fatty Acids Important?

Essential fatty acids are crucial for cell membranes, hormone production, and brain function.

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What are some Clinical Issues with Fatty Acids?

Saturated fats can contribute to obesity, heart disease, diabetes, and other conditions.

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What are the Benefits of Some Fatty Acids?

Omega-3 fatty acids, a type of unsaturated fat, have been linked to heart health and can lower triglycerides.

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Study Notes

Patient Case Study

  • A 55-year-old male presented to the emergency room (ER) complaining of crushing chest pain radiating to the left arm.
  • He is a chain smoker (25 years).
  • He also experienced mild chest pain when climbing stairs.

Lecture Objectives

  • Explain the chemical structure of fatty acids.
  • Classify fatty acids, providing examples.
  • Describe fatty acid properties and functions.
  • Explain the clinical significance of fatty acids.

Lipids

  • Lipids are insoluble in water but soluble in organic solvents (e.g., ether, benzene, acetone, chloroform).
  • Lipids are synonymous with fats, including waxes, oils, and steroids.

Lipid Sources

  • Lipids are found in both animals and plants.
  • Examples include butter, margarine, cooking oil, animal fat (subcutaneous fat), sausages, cheese, cakes, and cream.

Energy Yield from Nutrients

  • Fat = 9 Calories per gram
  • Carbohydrates = 4 Calories per gram
  • Protein = 4 Calories per gram

Essential Functions of Lipids

  • Act as a dietary carrier for lipid-soluble vitamins.
  • Supply essential polyunsaturated fatty acids.
  • Essential and other fatty acids formed from polyunsaturated fatty acid are important in membrane phospholipids.

Fatty Acids

  • Basic building blocks for lipids.
  • Saturated and Unsaturated (differ in the number of double bonds).

Fatty Acid Amphipathic Nature

  • Fatty acids have a polar head group and non-polar hydrocarbon tails.
  • This dual nature allows them to form structures like micelles where the hydrocarbon tails cluster together away from water and the polar heads interact with water.

Types of Fatty Acids

  • Saturated fatty acids (no double bonds).
  • Monounsaturated fatty acids (one double bond).
  • Polyunsaturated fatty acids (>1 double bond).

Saturated and Monounsaturated Fatty Acids

  • Double bonds in fatty acids are normally in a cis configuration.
  • Each cis double bond results in a kink in the fatty acid chain.

Important Fatty Acids

  • Palmitic acid (16:0)
  • Stearic acid (18:0)
  • Palmitoleic acid (16:1Δ9).
  • Oleic acid (18:1Δ9).
  • Linoleic acid (18:2Δ9,12).
  • Linolenic acid (18:3Δ9,12,15).
  • Arachidonic acid (20:4Δ5,8,11,14).

Fatty Acid Properties

  • Melting temperature of saturated fatty acids increases with increasing chain length.
  • Melting temperature of unsaturated fatty acids decreases with increasing double bonds.
  • Longer chain length decreases solubility, while more double bonds increase solubility in water.

Essential Fatty Acids

  • Linoleic acid (omega-6, 18:2) and linolenic acid (omega-3, 18:3) must be obtained from the diet.
  • Arachidonic acid is derived from linoleic acid and is a precursor for prostaglandins, thromboxanes, and leukotrienes (local hormones).

Omega Carbon

  • The carbon atom of the methyl group at the end of a hydrocarbon chain in a fatty acid is called the omega carbon.

Cardioprotective Effects of Omega-3 Fatty Acids

  • Omega-3 fatty acids are associated with a decreased risk of cardiovascular disease and a decrease in serum triglycerides.
  • Found in cold water fish (e.g., salmon, tuna, herring) and walnuts, flax seeds.

Rancidity

  • Rancidity results from oxidation of fats.
  • Polyunsaturated fats are more prone to rancidity than monounsaturated fats or saturated fats.
  • Food exposure to oxygen, heat, and light increases rancidity.

Hydrogenation of Vegetable Oils

  • Industry hydrogenates vegetable oils, saturating the fats.
  • This increases the melting point, converting liquid oils to solid fats (e.g., vanaspati ghee).

Trans Fats

  • Unsaturated fats that behave like saturated fats.
  • Produced by partial hydrogenation of liquid vegetable oils.
  • Found in many processed foods (e.g., baked goods, fried foods, margarine).

Food Sources of Trans Fats

  • Baked goods (cakes, cookies).
  • Shortening.
  • Microwave popcorn.
  • Frozen pizza.
  • Refrigerated dough (biscuits, rolls).
  • Fried foods (French fries, doughnuts, fried chicken).
  • Nondairy coffee creamer.
  • Stick margarine.

Harmful Effects of Trans Fats

  • Raise bad (LDL) cholesterol levels while lowering good (HDL) cholesterol levels.
  • Increase the risk of heart disease and stroke.

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