10 Questions
Which enzyme deficiency is associated with Lesch-Nyhan syndrome?
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Which of the following is a synthetic inhibitor of purine synthesis?
Allopurinol
In purine salvage pathway, which enzyme is responsible for conversion of hypoxanthine to inosine?
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Which of the following is NOT a purine nucleotide?
Cytidine triphosphate (CTP)
Which enzyme is involved in the synthesis of deoxyribonucleotides?
Thymidylate synthase
Which of the following is a purine nucleotide precursor that can be converted to hypoxanthine?
Xanthine
Which enzyme catalyzes the conversion of IMP to XMP in the de novo synthesis of purine nucleotides?
Adenylosuccinate synthetase
Which molecule is NOT involved in the de novo synthesis of pyrimidine nucleotides?
Cytosine
Which enzyme deficiency is associated with a form of severe combined immunodeficiency known as ADA-SCID?
Adenosine deaminase
Which of the following synthetic inhibitors is used to treat gout by targeting xanthine oxidase?
Allopurinol
Study Notes
Purine Metabolism Disorders
- Lesch-Nyhan syndrome is associated with a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT).
Purine Synthesis Inhibitors
- Synthetic inhibitors of purine synthesis include allopurinol.
Purine Salvage Pathway
- The enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is responsible for converting hypoxanthine to inosine.
Purine Nucleotides
- Thymidine is NOT a purine nucleotide.
Deoxyribonucleotide Synthesis
- Ribonucleotide reductase is the enzyme involved in the synthesis of deoxyribonucleotides.
Purine Nucleotide Precursors
- Inosinic acid is a purine nucleotide precursor that can be converted to hypoxanthine.
De Novo Synthesis of Purine Nucleotides
- The enzyme IMP dehydrogenase catalyzes the conversion of IMP to XMP.
De Novo Synthesis of Pyrimidine Nucleotides
- Thiamine is NOT involved in the de novo synthesis of pyrimidine nucleotides.
Immunodeficiency Disorders
- A deficiency of the enzyme adenosine deaminase (ADA) is associated with a form of severe combined immunodeficiency known as ADA-SCID.
Treatment of Gout
- Allopurinol is a synthetic inhibitor used to treat gout by targeting xanthine oxidase.
Test your knowledge of purine and pyrimidine structures, nucleosides, nucleotides, synthesis of purine nucleotides, synthetic inhibitors of purine synthesis, Lesch-Nyhan syndrome, and synthesis of deoxyribonucleotides in the context of nucleotide metabolism. This quiz is based on Chapter 22 'Nucleotide Metabolism' from the textbook Lippincott Illustrated Reviews Biochemistry, 8th edition, 2021.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
