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Questions and Answers
Which enzyme deficiency is associated with Lesch-Nyhan syndrome?
Which enzyme deficiency is associated with Lesch-Nyhan syndrome?
- Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (correct)
- Thymidine phosphorylase
- Adenosine deaminase
- Xanthine oxidase
Which of the following is a synthetic inhibitor of purine synthesis?
Which of the following is a synthetic inhibitor of purine synthesis?
- Cytarabine
- Gemcitabine
- 5-Fluorouracil
- Allopurinol (correct)
In purine salvage pathway, which enzyme is responsible for conversion of hypoxanthine to inosine?
In purine salvage pathway, which enzyme is responsible for conversion of hypoxanthine to inosine?
- 5'-Nucleotidase
- Adenosine deaminase
- Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (correct)
- Xanthine oxidase
Which of the following is NOT a purine nucleotide?
Which of the following is NOT a purine nucleotide?
Which enzyme is involved in the synthesis of deoxyribonucleotides?
Which enzyme is involved in the synthesis of deoxyribonucleotides?
Which of the following is a purine nucleotide precursor that can be converted to hypoxanthine?
Which of the following is a purine nucleotide precursor that can be converted to hypoxanthine?
Which enzyme catalyzes the conversion of IMP to XMP in the de novo synthesis of purine nucleotides?
Which enzyme catalyzes the conversion of IMP to XMP in the de novo synthesis of purine nucleotides?
Which molecule is NOT involved in the de novo synthesis of pyrimidine nucleotides?
Which molecule is NOT involved in the de novo synthesis of pyrimidine nucleotides?
Which enzyme deficiency is associated with a form of severe combined immunodeficiency known as ADA-SCID?
Which enzyme deficiency is associated with a form of severe combined immunodeficiency known as ADA-SCID?
Which of the following synthetic inhibitors is used to treat gout by targeting xanthine oxidase?
Which of the following synthetic inhibitors is used to treat gout by targeting xanthine oxidase?
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Study Notes
Purine Metabolism Disorders
- Lesch-Nyhan syndrome is associated with a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT).
Purine Synthesis Inhibitors
- Synthetic inhibitors of purine synthesis include allopurinol.
Purine Salvage Pathway
- The enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is responsible for converting hypoxanthine to inosine.
Purine Nucleotides
- Thymidine is NOT a purine nucleotide.
Deoxyribonucleotide Synthesis
- Ribonucleotide reductase is the enzyme involved in the synthesis of deoxyribonucleotides.
Purine Nucleotide Precursors
- Inosinic acid is a purine nucleotide precursor that can be converted to hypoxanthine.
De Novo Synthesis of Purine Nucleotides
- The enzyme IMP dehydrogenase catalyzes the conversion of IMP to XMP.
De Novo Synthesis of Pyrimidine Nucleotides
- Thiamine is NOT involved in the de novo synthesis of pyrimidine nucleotides.
Immunodeficiency Disorders
- A deficiency of the enzyme adenosine deaminase (ADA) is associated with a form of severe combined immunodeficiency known as ADA-SCID.
Treatment of Gout
- Allopurinol is a synthetic inhibitor used to treat gout by targeting xanthine oxidase.
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