Biochemistry II: De Novo Nucleotide Synthesis

Inhibition of dihydroorotate dehydrogenase prevents the formation of orotate, which is a crucial step in pyrimidine synthesis.

5-FU is converted to 5-F-dUMP, which inhibits thymidylate synthase, thereby preventing the formation of dTMP.

Azathioprine is metabolized to 6-MP, which inhibits de novo purine synthesis by inhibiting guanine phosphoribosyltransferase.

<p>Mycophenolate and ribavirin inhibit inosine monophosphate dehydrogenase, which is essential for the de novo synthesis of purines.</p> Signup and view all the answers

<p>Hydroxyurea inhibits ribonucleotide reductase, which is essential for the conversion of ribonucleotides to deoxyribonucleotides.</p> Signup and view all the answers

<p>MTX inhibits dihydrofolate reductase, which is essential for the conversion of dihydrofolate to tetrahydrofolate, a cofactor required for nucleotide synthesis.</p> Signup and view all the answers

<p>6-MP inhibits de novo purine synthesis by inhibiting guanine phosphoribosyltransferase.</p> Signup and view all the answers

<p>CPS2 is involved in the conversion of glutamine and CO₂ to carbamoyl phosphate, which is a precursor of orotic acid.</p> Signup and view all the answers

<p>Impaired orotic aciduria leads to a deficiency in pyrimidine synthesis, resulting in impaired nucleotide synthesis.</p> Signup and view all the answers