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What is the primary outcome of inhibition of dihydroorotate dehydrogenase in pyrimidine synthesis?
What is the primary outcome of inhibition of dihydroorotate dehydrogenase in pyrimidine synthesis?
Inhibition of dihydroorotate dehydrogenase prevents the formation of orotate, which is a crucial step in pyrimidine synthesis.
How does 5-fluorouracil (5-FU) inhibit thymidylate synthesis?
How does 5-fluorouracil (5-FU) inhibit thymidylate synthesis?
5-FU is converted to 5-F-dUMP, which inhibits thymidylate synthase, thereby preventing the formation of dTMP.
What is the primary effect of azathioprine on purine synthesis?
What is the primary effect of azathioprine on purine synthesis?
Azathioprine is metabolized to 6-MP, which inhibits de novo purine synthesis by inhibiting guanine phosphoribosyltransferase.
How do mycophenolate and ribavirin inhibit purine synthesis?
How do mycophenolate and ribavirin inhibit purine synthesis?
What is the primary effect of hydroxyurea on nucleotide synthesis?
What is the primary effect of hydroxyurea on nucleotide synthesis?
How does methotrexate (MTX) inhibit nucleotide synthesis?
How does methotrexate (MTX) inhibit nucleotide synthesis?
What is the primary effect of 6-mercaptopurine (6-MP) on purine synthesis?
What is the primary effect of 6-mercaptopurine (6-MP) on purine synthesis?
What is the role of carbamoyl phosphate synthetase II (CPS2) in pyrimidine synthesis?
What is the role of carbamoyl phosphate synthetase II (CPS2) in pyrimidine synthesis?
What is the primary outcome of impaired orotic aciduria?
What is the primary outcome of impaired orotic aciduria?
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