Biochemistry II BMPS 111: Citric Acid Cycle
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Questions and Answers

What percentage of the final mark is attributed to Continuous Assessment?

  • 30%
  • 40% (correct)
  • 60%
  • 50%
  • When is the Group Assignment due?

  • Tuesday February 6th
  • Friday January 22nd
  • Friday February 23rd (correct)
  • Monday January 22nd
  • What is the purpose of the Mid Semester Exam?

  • To prepare for the final exam
  • To assess understanding of Units 1-4
  • To evaluate student performance mid-semester (correct)
  • To complete the group assignment
  • What is the consequence of missing a test?

    <p>Focus on the next test</p> Signup and view all the answers

    How should students communicate with the lecturer?

    <p>Via email</p> Signup and view all the answers

    What is one of the learning outcomes of this course?

    <p>Describe the reactions of the citric acid cycle</p> Signup and view all the answers

    What is the primary function of the citric acid cycle?

    <p>To provide energy to the body</p> Signup and view all the answers

    What percentage of ATP is synthesized in the Krebs cycle?

    <p>65-70%</p> Signup and view all the answers

    What is the role of acetyl CoA in the citric acid cycle?

    <p>It is a metabolic intermediary</p> Signup and view all the answers

    What is the primary source of oxygen consumption in the body?

    <p>Citric acid cycle</p> Signup and view all the answers

    What is the name of the acid that participates at the outset of the citric acid cycle?

    <p>Citrate</p> Signup and view all the answers

    What is the role of the citric acid cycle in connecting individual metabolic pathways?

    <p>It acts as an amphibole</p> Signup and view all the answers

    What is the role of ADP in the citric acid cycle?

    <p>To ensure sufficient levels of NAD+ and FAD for the cycle to proceed</p> Signup and view all the answers

    What happens when NADH and FADH2 accumulate?

    <p>The enzymes of the citric acid cycle are inhibited</p> Signup and view all the answers

    What is the net ATP production by complete glucose oxidation?

    <p>38 ATP</p> Signup and view all the answers

    Which of the following is an activator of the TCA cycle?

    <p>Ca2+</p> Signup and view all the answers

    What is anaplerosis?

    <p>The replenishment of citric acid cycle intermediates</p> Signup and view all the answers

    What happens to the citric acid cycle when energy charge of the cell is high?

    <p>It is inhibited by ATP, succinyl CoA, and NADH</p> Signup and view all the answers

    Where are the enzymes of the TCA cycle located?

    <p>Mitochondrial matrix</p> Signup and view all the answers

    What is the function of pyruvate translocases?

    <p>To transport pyruvate across the mitochondrial membrane</p> Signup and view all the answers

    What is the function of the pyruvate dehydrogenase complex (PDH)?

    <p>To convert pyruvate to acetyl-CoA</p> Signup and view all the answers

    What is the characteristic of acetyl-CoA?

    <p>High energy compound with a high energetic thioester bond</p> Signup and view all the answers

    What is the first step in the reaction catalyzed by the PDH complex?

    <p>The acetyl group of pyruvate is attached to TPP</p> Signup and view all the answers

    What is the byproduct of the conversion of pyruvate to acetyl-CoA?

    <p>CO2</p> Signup and view all the answers

    In which tissues are high activities of pyruvate dehydrogenase (PDH) found?

    <p>Cardiac muscle and kidney</p> Signup and view all the answers

    What is the byproduct of the first step of the PDH complex reaction?

    <p>CO2</p> Signup and view all the answers

    What is the final product of the PDH complex reaction?

    <p>Acetyl-CoA</p> Signup and view all the answers

    What is the role of dihydrolipoyl dehydrogenase in the PDH complex reaction?

    <p>Converts reduced lipoamide to oxidized lipoamide</p> Signup and view all the answers

    What is the function of the PDH complex in glucose metabolism?

    <p>Converts pyruvate to Acetyl-CoA</p> Signup and view all the answers

    How many ATP can be generated from 2 moles of pyruvate formed from glucose?

    <p>6 ATP</p> Signup and view all the answers

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