Biochemistry II BMPS 111: Citric Acid Cycle

Play an AI-generated podcast conversation about this lesson

What percentage of the final mark is attributed to Continuous Assessment?

30%
40% (correct)
60%
50%

When is the Group Assignment due?

Tuesday February 6th
Friday January 22nd
Friday February 23rd (correct)
Monday January 22nd

What is the purpose of the Mid Semester Exam?

To prepare for the final exam
To assess understanding of Units 1-4
To evaluate student performance mid-semester (correct)
To complete the group assignment

What is the consequence of missing a test?

Focus on the next test (A) Signup and view all the answers

How should students communicate with the lecturer?

Via email (C) Signup and view all the answers

What is one of the learning outcomes of this course?

Describe the reactions of the citric acid cycle (C) Signup and view all the answers

What is the primary function of the citric acid cycle?

To provide energy to the body (B) Signup and view all the answers

What percentage of ATP is synthesized in the Krebs cycle?

65-70% (B) Signup and view all the answers

What is the role of acetyl CoA in the citric acid cycle?

It is a metabolic intermediary (A) Signup and view all the answers

What is the primary source of oxygen consumption in the body?

Citric acid cycle (D) Signup and view all the answers

What is the name of the acid that participates at the outset of the citric acid cycle?

Citrate (D) Signup and view all the answers

What is the role of the citric acid cycle in connecting individual metabolic pathways?

It acts as an amphibole (B) Signup and view all the answers

What is the role of ADP in the citric acid cycle?

To ensure sufficient levels of NAD+ and FAD for the cycle to proceed (C) Signup and view all the answers

What happens when NADH and FADH2 accumulate?

The enzymes of the citric acid cycle are inhibited (B) Signup and view all the answers

What is the net ATP production by complete glucose oxidation?

38 ATP (A) Signup and view all the answers

Which of the following is an activator of the TCA cycle?

Ca2+ (D) Signup and view all the answers

What is anaplerosis?

The replenishment of citric acid cycle intermediates (C) Signup and view all the answers

What happens to the citric acid cycle when energy charge of the cell is high?

It is inhibited by ATP, succinyl CoA, and NADH (C) Signup and view all the answers

Where are the enzymes of the TCA cycle located?

Mitochondrial matrix (C) Signup and view all the answers

What is the function of pyruvate translocases?

To transport pyruvate across the mitochondrial membrane (A) Signup and view all the answers

What is the function of the pyruvate dehydrogenase complex (PDH)?

To convert pyruvate to acetyl-CoA (D) Signup and view all the answers

What is the characteristic of acetyl-CoA?

High energy compound with a high energetic thioester bond (D) Signup and view all the answers

What is the first step in the reaction catalyzed by the PDH complex?

The acetyl group of pyruvate is attached to TPP (B) Signup and view all the answers

What is the byproduct of the conversion of pyruvate to acetyl-CoA?

CO2 (C) Signup and view all the answers

In which tissues are high activities of pyruvate dehydrogenase (PDH) found?

Cardiac muscle and kidney (A) Signup and view all the answers

What is the byproduct of the first step of the PDH complex reaction?

CO2 (C) Signup and view all the answers

What is the final product of the PDH complex reaction?

Acetyl-CoA (D) Signup and view all the answers

What is the role of dihydrolipoyl dehydrogenase in the PDH complex reaction?

Converts reduced lipoamide to oxidized lipoamide (B) Signup and view all the answers

What is the function of the PDH complex in glucose metabolism?

Converts pyruvate to Acetyl-CoA (C) Signup and view all the answers

How many ATP can be generated from 2 moles of pyruvate formed from glucose?

6 ATP (D) Signup and view all the answers