15 Questions
Which complex is responsible for transporting pyruvate into the mitochondria and converting it to Acetyl CoA?
Pyruvate dehydrogenase complex
Which coenzyme is derived from thiamin in the process of converting Pyruvate to Acetyl CoA?
Thiamin Pyrophosphate
What happens to Acetyl CoA when ATP is needed?
It enters into citric acid
What occurs in the regulation of pyruvate metabolism between meals?
Oxidation of fatty acids
During the well-fed state, what happens to Acetyl CoA under the influence of insulin?
It is shuttled into the cytoplasm for fatty acid synthesis
Which enzyme activates gluconeogenesis and inhibits PDH in the regulation between meals?
Pyruvate carboxylase
Which enzyme complex uses thiamine in a way similar to pyruvate dehydrogenase?
Citric acid cycle
What is the main cause of thiamine deficiency?
Alcohol abuse
Which element inhibits pyruvate dehydrogenase and α-ketoglutarate dehydrogenase?
Arsenite
Where do all enzymes of the citric acid cycle reside?
Mitochondrial matrix
Which enzyme of the citric acid cycle is bound to the inner mitochondrial membrane?
Succinate dehydrogenase
What is the total ATP yield from one molecule of acetyl CoA in the citric acid cycle?
12 ATP
What are the main factors regulating the citric acid cycle?
NADH, FADH2, and substrate availability
Which molecule inhibits isocitrate dehydrogenase in the citric acid cycle?
NADH
What happens to the citric acid cycle when oxygen levels decrease?
The cycle slows down
Test your knowledge on the Citric Acid Cycle, Pyruvate transportation, and enzymes involved such as Pyruvate decarboxylase, dihydrolipoyl transacetylase, and dihydrolipoyl dehydrogenase. Explore the coenzymes involved in the process including Thiamin Pyrophosphate, Lipoic acid, Co enzyme A, FAD(H2), and NAD(H).
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