Biochemistry: Citric Acid Cycle and Enzymes
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Questions and Answers

Which complex is responsible for transporting pyruvate into the mitochondria and converting it to Acetyl CoA?

  • Dihydrolipoyl dehydrogenase
  • Pyruvate decarboxylase
  • Dihydrolipoyl transacetylase
  • Pyruvate dehydrogenase complex (correct)
  • Which coenzyme is derived from thiamin in the process of converting Pyruvate to Acetyl CoA?

  • FAD(H2)
  • Thiamin Pyrophosphate (correct)
  • Coenzyme A
  • Lipoic acid
  • What happens to Acetyl CoA when ATP is needed?

  • It activates fatty acid synthesis
  • It enters into citric acid (correct)
  • It is converted to glucose
  • It inhibits Pyruvate dehydrogenase
  • What occurs in the regulation of pyruvate metabolism between meals?

    <p>Oxidation of fatty acids</p> Signup and view all the answers

    During the well-fed state, what happens to Acetyl CoA under the influence of insulin?

    <p>It is shuttled into the cytoplasm for fatty acid synthesis</p> Signup and view all the answers

    Which enzyme activates gluconeogenesis and inhibits PDH in the regulation between meals?

    <p>Pyruvate carboxylase</p> Signup and view all the answers

    Which enzyme complex uses thiamine in a way similar to pyruvate dehydrogenase?

    <p>Citric acid cycle</p> Signup and view all the answers

    What is the main cause of thiamine deficiency?

    <p>Alcohol abuse</p> Signup and view all the answers

    Which element inhibits pyruvate dehydrogenase and α-ketoglutarate dehydrogenase?

    <p>Arsenite</p> Signup and view all the answers

    Where do all enzymes of the citric acid cycle reside?

    <p>Mitochondrial matrix</p> Signup and view all the answers

    Which enzyme of the citric acid cycle is bound to the inner mitochondrial membrane?

    <p>Succinate dehydrogenase</p> Signup and view all the answers

    What is the total ATP yield from one molecule of acetyl CoA in the citric acid cycle?

    <p>12 ATP</p> Signup and view all the answers

    What are the main factors regulating the citric acid cycle?

    <p>NADH, FADH2, and substrate availability</p> Signup and view all the answers

    Which molecule inhibits isocitrate dehydrogenase in the citric acid cycle?

    <p>NADH</p> Signup and view all the answers

    What happens to the citric acid cycle when oxygen levels decrease?

    <p>The cycle slows down</p> Signup and view all the answers

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