Biochemistry: Citric Acid Cycle and Enzymes

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Questions and Answers

Which complex is responsible for transporting pyruvate into the mitochondria and converting it to Acetyl CoA?

  • Dihydrolipoyl dehydrogenase
  • Pyruvate decarboxylase
  • Dihydrolipoyl transacetylase
  • Pyruvate dehydrogenase complex (correct)

Which coenzyme is derived from thiamin in the process of converting Pyruvate to Acetyl CoA?

  • FAD(H2)
  • Thiamin Pyrophosphate (correct)
  • Coenzyme A
  • Lipoic acid

What happens to Acetyl CoA when ATP is needed?

  • It activates fatty acid synthesis
  • It enters into citric acid (correct)
  • It is converted to glucose
  • It inhibits Pyruvate dehydrogenase

What occurs in the regulation of pyruvate metabolism between meals?

<p>Oxidation of fatty acids (D)</p> Signup and view all the answers

During the well-fed state, what happens to Acetyl CoA under the influence of insulin?

<p>It is shuttled into the cytoplasm for fatty acid synthesis (D)</p> Signup and view all the answers

Which enzyme activates gluconeogenesis and inhibits PDH in the regulation between meals?

<p>Pyruvate carboxylase (C)</p> Signup and view all the answers

Which enzyme complex uses thiamine in a way similar to pyruvate dehydrogenase?

<p>Citric acid cycle (B)</p> Signup and view all the answers

What is the main cause of thiamine deficiency?

<p>Alcohol abuse (A)</p> Signup and view all the answers

Which element inhibits pyruvate dehydrogenase and α-ketoglutarate dehydrogenase?

<p>Arsenite (D)</p> Signup and view all the answers

Where do all enzymes of the citric acid cycle reside?

<p>Mitochondrial matrix (B)</p> Signup and view all the answers

Which enzyme of the citric acid cycle is bound to the inner mitochondrial membrane?

<p>Succinate dehydrogenase (B)</p> Signup and view all the answers

What is the total ATP yield from one molecule of acetyl CoA in the citric acid cycle?

<p>12 ATP (D)</p> Signup and view all the answers

What are the main factors regulating the citric acid cycle?

<p>NADH, FADH2, and substrate availability (A)</p> Signup and view all the answers

Which molecule inhibits isocitrate dehydrogenase in the citric acid cycle?

<p>NADH (A)</p> Signup and view all the answers

What happens to the citric acid cycle when oxygen levels decrease?

<p>The cycle slows down (D)</p> Signup and view all the answers

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