COPY: Biochemistry Chapter: Proteins and Their Functions
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Questions and Answers

What is the molecular weight of Prealbumin?

62 kDa

Prealbumin is an immature form of albumin.

False

Prealbumin has a longer half-life compared to albumin.

False

What is the primary function of Alpha1-Antitrypsin?

<p>Neutralizing trypsin and trypsin-like enzymes.</p> Signup and view all the answers

What is another name for Alpha1-Antitrypsin?

<p>Alpha1-Antiproteinase</p> Signup and view all the answers

What is the molecular weight of Alpha1-Antitrypsin?

<p>53 kDa</p> Signup and view all the answers

What is the most common phenotype of Alpha1-Antitrypsin?

<p>MM phenotype</p> Signup and view all the answers

The SZ genotype is associated with a higher risk of emphysema.

<p>True</p> Signup and view all the answers

What is the main role of Alpha1-Antitrypsin in elastase regulation?

<p>To inhibit elastase activity.</p> Signup and view all the answers

What is the most common cause of lung inflammation?

<p>Smoking</p> Signup and view all the answers

What amino acid residue is oxidized by smoking in Alpha1-Antitrypsin?

<p>Methionine-358 (Met-358)</p> Signup and view all the answers

Reduced elastase activity leads to the formation of larger air spaces in the lungs.

<p>False</p> Signup and view all the answers

The PiZZ genotype is particularly severe in emphysema patients due to a significant deficiency in functional alpha1-antitrypsin.

<p>True</p> Signup and view all the answers

Mutations in the alpha1-antitrypsin gene can alter the protein's shape, leading to aggregation.

<p>True</p> Signup and view all the answers

Where is Alpha1-fetoprotein synthesized?

<p>In the yolk sac of the fetus and later by liver parenchyma cells.</p> Signup and view all the answers

Low levels of Alpha1-fetoprotein are associated with Down's syndrome.

<p>True</p> Signup and view all the answers

What is the molecular weight of Haptoglobin?

<p>90 kDa</p> Signup and view all the answers

Haptoglobin's half-life is shortened when it binds to hemoglobin.

<p>True</p> Signup and view all the answers

What is the molecular weight of Ceruloplasmin?

<p>160 kDa</p> Signup and view all the answers

Most of the copper in the blood is bound to Ceruloplasmin.

<p>True</p> Signup and view all the answers

What is the genetic liver disorder associated with low Ceruloplasmin levels?

<p>Wilson's disease</p> Signup and view all the answers

What type of enzyme is ferroxidase?

<p>A ferroxidase</p> Signup and view all the answers

What does CRP stand for?

<p>C-reactive protein</p> Signup and view all the answers

What is the normal range for CRP levels?

<p>Less than 5</p> Signup and view all the answers

Most plasma proteins are synthesized in the liver.

<p>True</p> Signup and view all the answers

Elevated levels of gamma globulins can indicate cancer.

<p>True</p> Signup and view all the answers

Renal failure can lead to a decrease in all protein bands in circulation.

<p>True</p> Signup and view all the answers

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