BIO207H5S Introductory Genetics Winter 2024 Lecture 5: Sex Determination and Sex-linked Inheritance
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Questions and Answers

In the XX-XY sex determination system, which of the following statements is true?

  • Males produce only X gametes.
  • Females produce both X and Y gametes.
  • All somatic cells in human females contain one X and one Y chromosome.
  • Males inherit their X chromosome from their father and their Y chromosome from their mother. (correct)

How many genes are there on the Y chromosome compared to the X chromosome in humans?

  • Equal number of genes on both X and Y chromosomes
  • 900–1400 genes on the Y chromosome and ~75 genes on the X chromosome (correct)
  • Y chromosome has more genes than the X chromosome
  • Both X and Y chromosomes have around 1000 genes

What determines maleness in the XX-XY sex determination system?

  • Sperm cells that carry the X chromosome
  • Females producing only X gametes
  • Presence of two X chromosomes
  • Sperm cells that carry the Y chromosome (correct)

During early development, every human embryo is potentially hermaphroditic until around which week of gestation?

<p>Fifth week (D)</p> Signup and view all the answers

At what stage does the gonadal tissue of a human embryo become sexually indifferent or neutral?

<p>Fifth week of gestation (B)</p> Signup and view all the answers

Which part of the neutral gonadal tissue may develop into a testis in a human embryo?

<p>Medulla (C)</p> Signup and view all the answers

In humans, how many X chromosomes do males inherit from each parent?

<p>No X chromosomes from their father and one X chromosome from their mother (A)</p> Signup and view all the answers

Which type of sex cells do females produce in the XX-XY sex determination system?

<p><strong>X</strong> gametes (A)</p> Signup and view all the answers

What can be distinguished at the stage where the gonadal phenotype is sexually indifferent?

<p>Neither male nor female reproductive structures (D)</p> Signup and view all the answers

What determines maleness in humans according to the XX-XY sex determination system?

<p>Sperm cells that carry the Y chromosome (B)</p> Signup and view all the answers

In the XX-XO system, which of the following accurately describes the determination of maleness?

<p>Males carry only one X chromosome (XO) (B)</p> Signup and view all the answers

What is the role of the Wolffian ducts and Müllerian ducts in each embryo?

<p>Differentiate into structures of the male reproductive tract (D)</p> Signup and view all the answers

What is the function of the testis determining factor?

<p>Cause undifferentiated gonadal tissue to form testes (C)</p> Signup and view all the answers

What are the pseudoautosomal regions (PARs) critical for?

<p>Segregation of the X and Y chromosomes during male gametogenesis (B)</p> Signup and view all the answers

What genetic consequences result from having more than two copies of pseudoautosomal regions (PARs)?

<p>Klinefelter’s Syndrome (XXY) (C)</p> Signup and view all the answers

What is the function of Barr bodies in somatic cells of females?

<p>Compensate for X chromosome dosage disparities (D)</p> Signup and view all the answers

According to the Lyon hypothesis, when does X chromosome inactivation occur?

<p>At the blastocyst 4- to 8-cell stage of development (A)</p> Signup and view all the answers

What is the basis for sex determination in organisms with Haplodiploidy?

<p>Number of chromosomes found per cell (C)</p> Signup and view all the answers

What is the mechanism of sex determination in organisms with XX-XY system?

<p>Females have XX chromosomes and males have XY chromosomes (B)</p> Signup and view all the answers

In Drosophila melanogaster, which one of the following accurately describes the sex-linkage pattern for the gene controlling eye color?

<p>F1 : Red eyed female : Red eyed male : white eyed male :: 2:1:1 (C)</p> Signup and view all the answers

What did Calvin Bridges' observation of flies with unusual phenotypes cytogenetically confirm?

<p>Non-disjunction of chromosomes during gamete formation (B)</p> Signup and view all the answers

Which statement accurately represents Morgan’s Hypothesis on X-linkage in Drosophila melanogaster?

<p>Males have only one available gene site on their single X chromosome, whereas females have two available gene sites, one on each X chromosome. (C)</p> Signup and view all the answers

What was the significance of conducting reciprocal crosses in the study of sex-linkage in Drosophila?

<p>It allowed researchers to test if a gene or trait is autosomal or sex-linked. (A)</p> Signup and view all the answers

What did the observation of unexpected phenotypes at a frequency more than the expected mutation rate in Morgan’s crosses indicate?

<p>Non-disjunction of chromosomes during gamete formation (A)</p> Signup and view all the answers

What was one result of X-linkage according to Morgan’s hypothesis?

<p>Phenotypic traits controlled by recessive X-linked genes are passed from homozygous mothers to all sons. (C)</p> Signup and view all the answers

Which of the following accurately describes the F1 offspring obtained in a reciprocal cross for an autosomal gene or trait?

<p>All offspring will show the dominant phenotype for F1 for any monohybrid cross. (B)</p> Signup and view all the answers

In Morgan’s studies, what did the observation of a white eyed male fly as opposed to red eyed flies lead to?

<p>Curiosity that led to documenting one of the first cases of sex-linkage in Drosophila. (D)</p> Signup and view all the answers

What genetic phenomenon did Calvin Bridges' observation confirm about the flies with unusual phenotypes?

<p>Non-disjunction of chromosomes during gamete formation. (B)</p> Signup and view all the answers

What did Bridges' observation confirm about the flies' rare phenotypes?

<p>They were associated with particular chromosomes due to non-disjunction during gamete formation. (D)</p> Signup and view all the answers

What is the sex determination system present in butterflies, birds, some reptiles, and amphibians?

<p>ZZ-ZW system (C)</p> Signup and view all the answers

According to Bridges, what plays a critical role in sex determination in Drosophila melanogaster?

<p>X chromosomes and autosomes (B)</p> Signup and view all the answers

What did Thomas H. Morgan observe in his Drosophila lab cultures, leading to his studies of sex-linkage?

<p>A white eyed male fly (D)</p> Signup and view all the answers

What was Morgan's hypothesis regarding the allele for white eyes in Drosophila?

<p>It is found on the X chromosome but absent from the Y chromosome (B)</p> Signup and view all the answers

What is the definitive method to test for sex-linkage?

<p>Reciprocal crosses (B)</p> Signup and view all the answers

In a reciprocal cross, if the gene or trait is autosomal, what will be observed in the offspring?

<p>All of the offspring will show the dominant phenotype for F1 for any monohybrid cross (D)</p> Signup and view all the answers

What is observed in the offspring of a reciprocal cross if the gene or trait is sex-linked?

<p>The offspring in F1 or F2 obtained in a reciprocal cross will be different (D)</p> Signup and view all the answers

What did Calvin Bridges observe under the microscope to confirm his hypothesis regarding unusual phenotypes?

<p>Chromosomes associated with particular phenotypes (A)</p> Signup and view all the answers

What did unexpected phenotypes appearing at a frequency more than the expected mutation rate provide definite proof for?

<p>Chromosomal theory of inheritance (A)</p> Signup and view all the answers

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