Bio 2601: Gas Exchange Lecture 6

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Questions and Answers

According to the provided information, what is the primary challenge faced by air-breathers regarding CO2 excretion?

  • The limited surface area available for gas exchange in the respiratory system, affecting CO2 removal.
  • The rapid conversion of CO2 to carbonic acid in the lungs, hindering direct excretion.
  • The high concentration of CO2 in the air, creating a diffusion gradient that is unfavorable for excretion.
  • The low concentration of CO2 in the air necessitates a high partial pressure of CO2 for diffusion to occur. (correct)

In mammals, which of the following chemoreceptors plays the most significant role in regulating breathing, as indicated by the content?

  • Central chemoreceptors in the medulla. (correct)
  • Peripheral chemoreceptors in the carotid bodies.
  • Peripheral chemoreceptors in the aortic bodies.
  • Both peripheral and central chemoreceptors play equal roles in regulating overall breathing.

Considering the information provided, what is the main advantage water-breathers have over air-breathers in regard to CO2 excretion?

  • Water-breathers usually have low CO2 concentrations in water, which allows for easier diffusion out of their body. (correct)
  • Water-breathers have high concentrations of CO2 in their respiratory medium, causing a higher expulsion gradient.
  • The higher solubility of CO2 in water facilitates better excretion of the gas for water-breathers.
  • Water-breathers have a more developed respiratory system, allowing for efficient transfer.

For bimodal breathers, how is blood typically re-routed to manage oxygen and carbon dioxide exchange effectively?

<p>Blood is re-routed such that oxygen is taken up mainly by the lungs from air while carbon dioxide is released mostly through the gills into the water. (A)</p> Signup and view all the answers

Based on the provided content, what strategy do some air-breathing animals use when in water?

<p>They absorb oxygen through the lungs in air and release carbon dioxide through their permeable skin in water. (C)</p> Signup and view all the answers

In the context of oxygen transport, what is the role of respiratory pigments, and what unique adaptation is observed in the Antarctic icefish?

<p>Respiratory pigments facilitate oxygen binding and transport; icefish lack them, utilizing increased blood volume to ensure sufficient oxygen supply. (B)</p> Signup and view all the answers

According to the content, what is the primary mechanism by which most carbon dioxide is transported in the blood, and what role does carbonic anhydrase (CA) play in this process?

<p>Most CO2 is transported as bicarbonate; CA facilitates its conversion to carbonic acid, in red blood cells from where it dissociates into bicarbonate and hydrogen ions (A)</p> Signup and view all the answers

Based on the content, in what direction will the reaction $HbH + O_2 \rightleftharpoons HbO_2 + H^+$ in the tissues and the lungs?

<p>The reaction favors $HbO_2$ formation in the lungs and $HbH$ formation in tissues due to the changes in partial pressure of oxygen. (A)</p> Signup and view all the answers

During CO2 excretion at working tissues, how is the charge balance maintained when bicarbonate ($HCO_3^−$) is transported from red blood cells to the plasma, and what specific protein is responsible for this process?

<p>Chloride ions ($Cl^−$) are transported into the RBCs through band 3 protein. (B)</p> Signup and view all the answers

Following the description of $CO_2$ excretion, what happens to the majority of $HCO_3^−$ when it reaches the gas exchange surface (lungs/gills)?

<p>It is converted back to $CO_2$ which then diffuses out into the lung/gill. (D)</p> Signup and view all the answers

Flashcards

CO2 Excretion

The process of removing carbon dioxide (CO2) from the body.

CO2 Excretion in Air Breathers

The partial pressure of CO2 (pCO2) in the air is relatively low. This makes diffusion of CO2 from the body to the air challenging for air-breathing animals.

Fick's Law of Diffusion

The rate of diffusion is directly proportional to the surface area and the difference in partial pressure (P1 - P2) between the two compartments, and inversely proportional to the distance (X).

Peripheral Chemoreceptors

Chemoreceptors in the carotid and aortic bodies detect changes in blood oxygen, carbon dioxide, and pH levels. These signals are sent to the medulla oblongata, the brain's respiratory center.

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Nitrogenous Waste in Freshwater Fish

Fish excrete ammonia (NH3) as their primary nitrogenous waste. This is because ammonia is highly toxic and must be excreted quickly. It can be dissolved in water and easily removed.

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Respiratory Pigments and Oxygen Carrying Capacity

The amount of oxygen that can be carried by the blood is determined by the concentration of respiratory pigments. Hemoglobin is the most common respiratory pigment, and its concentration varies depending on the species and its environment.

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Bohr Effect

The binding of oxygen to hemoglobin is influenced by pH levels. Low pH (acidic) favors the release of oxygen, while high pH (alkaline) promotes oxygen binding. This relationship is known as the Bohr effect and is important for delivering oxygen to tissues that need it most.

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CO2 Transport and Bicarbonate Formation

Carbon dioxide (CO2) is produced as a byproduct of cellular respiration. CO2 is transported through the blood in different forms, primarily as bicarbonate ions (HCO3-). The enzyme carbonic anhydrase (CA) plays a crucial role in this conversion.

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CO2 Excretion: From Tissue to Respiratory Surface

The process of CO2 moving from the tissue to the blood and ultimately to the respiratory surface for excretion involves a series of steps. CO2 first diffuses from the tissue into the blood. In the blood, most CO2 is converted to bicarbonate ions, which are then transported to the respiratory surface. At the respiratory surface, the process is reversed, and CO2 is released for exhalation.

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Band 3 Protein and Bicarbonate Transport

The transport of bicarbonate ions across the red blood cell membrane is facilitated by a specific protein called band 3, which exchanges bicarbonate ions for chloride ions. This exchange helps maintain the balance of ions and ensures the efficient transport of bicarbonate.

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Study Notes

Lecture 6: Gas Exchange

  • Lecture date: January 17
  • Topics covered: CO2 exchange, regulating breathing
  • Reading assignments: pages 677-685 and 620-638
  • Review pages: 654-677

Respiratory Pigments

  • Covered in Bio 2601
  • Students expected to know the topic
  • Students should understand hematocrit
  • Blood components diagram included

Antarctic Icefish

  • Lives in -1.9°C water
  • Lacks respiratory pigments
  • How does it get enough oxygen?
  • Possible advantages of lacking respiratory pigments?
  • Are there other animals without respiratory pigments?

Pigments & Oxygen Carrying Capacity

  • Graph showing oxygen equilibrium curve (total O2)
  • Relationship between partial pressure of O2 and oxygen content of blood
  • P50 values are shown on second graph
  • Describes high/low hemoglobin content

Percent Saturation of Oxygen

  • Graph shows percent saturation vs. partial pressure of O2
  • Formula shown is HpH + O2 ↔ HbO2 + H+

Oxygen Concentration of Blood

  • Graph showing O2 concentration vs. partial pressure of oxygen in blood
  • Illustrates changes in O2 concentration during rest and exercise

Effect of Temperature on P50

  • Graph showing how temperature affects oxygen saturation curves
  • Partial pressure of O2 in the blood is shown on graph

Hemoglobin at Working Tissues

  • Graph shows effect of pH change on hemoglobin saturation
  • Different pH levels (7.6, 7.4 and 7.2) are shown on the graph
  • Variation of CO₂ partial pressure are included on the graph

CO2 Excretion

  • Location of CO2 production
  • CO2 diffuses freely across epithelia/membranes
  • CO2 is not very soluble
  • Converting CO2 to bicarbonate (HCO3-)
  • Most CO2 transported as bicarbonate
  • Carbonic anhydrase role in RBCs
  • Diagram showing conversion reaction

CO2 Excretion: Working Tissues

  • CO2 diffuses from tissue to plasma & RBCs
  • Little CO2 binds to hemoglobin (Hb)
  • Converts to carbonic acid (H₂CO₃) by carbonic anhydrase (CA)
  • Then to bicarbonate (HCO₃⁻)
  • What happens to H⁺? effect on Hb?
  • Bicarbonate moves to plasma
  • Rapid anion exchange protein carries chloride ions (Cl⁻) into cells instead of bicarbonate
  • Explains CO2 transport in plasma as bicarbonate

CO2 Excretion: Gas Exchange Surface

  • Bicarbonate (HCO₃⁻) cannot diffuse across membranes
  • Converting back to CO2 for release
  • Effect on equilibrium

CO2 Excretion in Air-Breathers

  • Challenge of low CO2 levels in air
  • High pCO2 is needed for diffusion
  • Graph relating CO2 partial pressure to oxygen partial pressure

Blood Gases & Breathing

  • Chemoreceptors (peripheral, carotid, and aortic bodies and central medulla) involved in detecting blood gas levels
  • Details on chemoreceptor locations and roles

Regulating Breathing and Data Interpretations

  • Graphs relating ventilation rate (% values) to O2/CO2 % values in air/water breathers.
  • Data interpretations for air breathers

Unusual Air-Breathers

  • Issue of CO2 concentration for air breathers
  • Coping strategies used by different species

CO2 Excretion in Water-Breathers

  • CO2 excretion is generally easy in water due to water's solubility of CO2
  • conversion to bicarbonate
  • Diffusion gradient for CO2 and its consequences

What about Water Breathers?

  • Diagram showing oxygen partial pressure in relation to ventilation rate
  • Data for varieties of water vent rates

Gas Exchange: Bimodal Breathers

  • Oxygen exchange mainly via lungs
  • Carbon dioxide exchange mainly via gills
  • Blood routing required

Gas Exchange: Skin Breathers

  • Oxygen exchange through lungs and permeable skin
  • CO2 excretion data interpretation

Unusual Water Breathers

  • Nitrogenous waste excretion by freshwater fish
  • Conversion to ammoniac
  • Soda lakes/water high in CO2

Ornithine-Urea Cycle

  • Diagram of the cycle, and metabolic pathways involved

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