BIO 246 JC #2 Alzheimer’s Disease Pathology Quiz

To identify or isolate proteins using biochemical techniques like western blotting or immunofluorescence.

It binds to the primary antibody and is used to detect emitted fluorescence.

By using a pinhole to selectively capture in-focus light.

<p>To detect specific proteins in a sample.</p> Signup and view all the answers

<p>By retroviral transduction of the avian myc oncogene into cells of neonatal mouse cerebellum.</p> Signup and view all the answers

<p>Arachidonic acid.</p> Signup and view all the answers

<p>Beta-amyloid plaques and neurofibrillary tangles of tau</p> Signup and view all the answers

<p>Neurons are dying due to misfolded tau protein, leading to the formation of neurofibrillary tangles.</p> Signup and view all the answers

<p>The authors hypothesize that tau spreads through a 'prion-like' mechanism, where extracellular tau enters neighbor neurons and seeds misfolding of intracellular tau protein.</p> Signup and view all the answers

<p>Tau has been observed in the cerebrospinal fluid (CSF) and in extracellular aggregates known as 'ghost tangles'.</p> Signup and view all the answers

<p>YFP is a genetic mutant of green fluorescent protein (GFP) derived from jellyfish Aequorea victoria.</p> Signup and view all the answers

<p>Ghost tangles are made up of the microtubule binding region (MTBR) of full-length tau protein.</p> Signup and view all the answers