BIO 202 Chapter 17: Olfactory and Sensory Reception

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Questions and Answers

Given the complexities of olfactory discrimination, if a novel anosmic agent selectively ablates sustentacular cells within the olfactory epithelium, what specific downstream effect would most immediately compromise olfactory reception, assuming olfactory sensory neurons remain structurally intact initially?

  • Disruption of odorant-binding protein synthesis, preventing odorant molecule interaction.
  • Reduced production of mucus, impeding the dissolution and transport of hydrophobic odorants. (correct)
  • Impairment of basal epithelial cell differentiation, leading to a depletion of olfactory sensory neuron progenitors.
  • Aberrant regulation of ion homeostasis within the olfactory epithelium, directly depolarizing olfactory sensory neurons independently of odorant stimulation.

In the context of gustatory transduction, if a novel pharmacological agent selectively inhibits the activity of phospholipase C (PLC) in taste receptor cells, which of the following taste modalities would be MOST directly impaired?

  • Salty
  • Umami
  • Sour
  • Sweet (correct)

Considering the intricacies of the lacrimal apparatus, identify the most probable consequence of a complete obstruction within the lacrimal canaliculi, proximal to the lacrimal sac?

  • Retrograde bacterial infection ascending into the lacrimal gland, inducing acute dacryoadenitis.
  • Excessive tear production due to feedback mechanism dysregulation.
  • Compromised tear distribution across the conjunctival surface, potentially leading to localized desiccation. (correct)
  • Increased lysozyme concentration within the remaining tear fluid, exacerbating ocular surface irritation.

If a mutation caused non-functional crystallins, what would be the most likely result?

<p>The lens would become opaque. (B)</p> Signup and view all the answers

Given the intricacies of phototransduction, if a novel, highly specific antagonist to rhodopsin kinase were introduced into the retinal environment, which of the following immediate consequences would most likely occur?

<p>Prolonged activation of transducin, leading to sustained hyperpolarization of photoreceptors. (C)</p> Signup and view all the answers

Considering the neural circuitry of visual processing, what specific functional deficit would be expected following selective ablation of all horizontal cells within the retina?

<p>Impaired ability to adapt to changes in light intensity and contrast. (B)</p> Signup and view all the answers

After a traumatic brain injury a patient has the inability to detect the position of their head, which structure has most likely been damaged?

<p>Vestibular ganglia (C)</p> Signup and view all the answers

Given the complex physiology of hearing, if a novel ototoxic drug selectively targets and destroys outer hair cells within the organ of Corti, what immediate and primary auditory deficit would be most anticipated?

<p>Significant reduction in auditory sensitivity and frequency discrimination. (B)</p> Signup and view all the answers

Following the severing of the right optic nerve a patient would be expected to have?

<p>Loss of vision in the right eye. (D)</p> Signup and view all the answers

Within the olfactory system, what specific enzymatic process is MOST directly responsible for terminating the generator potential in olfactory sensory neurons following odorant binding?

<p>Hydrolysis of GTP bound to G-alpha subunits by intrinsic GTPase activity. (C)</p> Signup and view all the answers

In the context of gustatory signal transduction, if a research team develops a highly selective inhibitor of the TRPM5 ion channel expressed in taste receptor cells, which specific taste modality would be MOST directly affected?

<p>Bitter (C)</p> Signup and view all the answers

What specific biophysical mechanism underlies the phenomenon of accommodation, allowing the eye to focus on objects at varying distances?

<p>Relaxation of the ciliary muscle, reducing tension on the suspensory ligaments and allowing the lens to become more spherical. (A)</p> Signup and view all the answers

Which cellular component contains glands producing thick secretions at the medial angle of the eye?

<p>Lacrimal caruncle (C)</p> Signup and view all the answers

In the context of scotopic vision, what specific adaptation within rod photoreceptors contributes MOST significantly to their heightened sensitivity to low light levels?

<p>Increased amplification within their phototransduction cascade. (B)</p> Signup and view all the answers

What would happen to a patient with their tensor tympani severed?

<p>The patient would have increased sensitivity to loud noises. (D)</p> Signup and view all the answers

Given the complexities of the auditory pathways, if a lesion selectively ablates the medial geniculate body (MGB) of the thalamus bilaterally, which specific auditory function would be MOST severely compromised?

<p>Conscious perception and discrimination of complex auditory stimuli. (D)</p> Signup and view all the answers

What is the functional consequence of horizontal cell inhibition on bipolar cells within the retina?

<p>Horizontal cells sharpen the center-surround antagonism in bipolar cells, improving contrast detection. (A)</p> Signup and view all the answers

Within the vestibular system, what is the functional role of otoliths?

<p>Otoliths increase the inertia of the macula, deflecting hair cell stereocilia in response to gravity and linear acceleration. (D)</p> Signup and view all the answers

A drug blocks the neurotransmitter being released by the hair cells in the cochlea, what would be the result?

<p>The individual would be unable to hear sounds. (D)</p> Signup and view all the answers

If damage occurred to hair cells in the saccule, but not the utricle, of the vestibular system, what specific sensory deficit would be most likely observed?

<p>Inability to perceive vertical linear acceleration. (A)</p> Signup and view all the answers

If a patient presents with a lesion affecting the right optic tract posterior to the optic chiasm, what visual field deficit would be expected?

<p>Left homonymous hemianopia (B)</p> Signup and view all the answers

In the context of olfactory signal transduction, what is the specific role of cyclic AMP (cAMP) in generating the generator potential within olfactory sensory neurons?

<p>cAMP binds to and opens cyclic nucleotide-gated (CNG) channels, allowing influx of cations and depolarization. (D)</p> Signup and view all the answers

After administration of a novel diuretic, a patient develops a selective hyposensitivity to salty taste. Electrophysiological studies reveal normal function of amiloride-sensitive sodium channels in taste receptor cells. Which of the following intracellular signaling molecules would most likely be directly implicated in this acquired taste deficit?

<p>Transient receptor potential cation channel 1 (TRPC1) (B)</p> Signup and view all the answers

Given common etiologies for scotomas, what specific pathological process within the visual pathway would MOST likely result in an arcuate scotoma, respecting the anatomical distribution of nerve fibers?

<p>Ischemic optic neuropathy affecting the watershed zone of the optic nerve head. (D)</p> Signup and view all the answers

Flashcards

Olfaction

Sense of smell

Olfactory organs

Sensory organs for smell, located in the nasal cavity on either side of the nasal septum.

Olfactory epithelium

Contains olfactory sensory neurons, supporting cells, and basal epithelial cells.

Olfactory sensory neurons

Detection of dissolved chemicals interacting with odorant-binding proteins.

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Olfactory reception

Begins with an odorant binding to a G protein-coupled receptor, creating depolarization.

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Olfactory pathways

Afferent fibers that leave the olfactory epithelium and collect into bundles, penetrating the cribriform plate, reaching olfactory bulbs of the cerebrum where the first synapse occurs.

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Olfactory cortex

Where axons leaving the olfactory bulb travel along the olfactory tract to, including the hypothalamus and limbic system.

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Gustation

The sense of taste

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Taste buds

Provide information about foods and liquids consumed and contain gustatory epithelial cells.

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Lingual papillae

Epithelial projections on the surface of the tongue associated with taste buds.

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Filiform papillae

Provide friction, do not contain taste buds.

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Fungiform papillae

Contains about five taste buds each.

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Vallate papillae

Contain as many as 100 taste buds each.

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Foliate papillae

Has taste buds.

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Gustatory epithelial cells

Extend microvilli through taste pore, survive about 10 days.

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Primary taste sensations

Sweet, salty, sour, and bitter

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Umami

Pleasant, savory taste imparted by glutamate.

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Water taste sensation

Detected by water receptors in pharynx.

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Accessory structures of the eye

Provide protection lubrication and support for the eye.

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Eyelids (palpebrae)

A continuation of skin; blinking keeps surface of eye lubricated and clean.

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Tarsal glands

Secrete lipid-rich product that helps keep eyelids from sticking together.

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Lacrimal apparatus

Produces, distributes, and removes tears; contains lysozyme.

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Aqueous humor

Fluid that circulates within anterior cavity of eye and maintains intra-ocular pressure.

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Vitreous body

Gelatinous mass in posterior cavity that helps stabilize shape of eye.

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Cornea

Outer transparent portion of the fibrous layer of the eye.

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