Biliary Tract Diseases and Primary Sclerosing Cholangitis

Elevated alkaline phosphatase (ALP) is a typical pattern in liver function tests (LFTs) associated with biliary tract disease.

A condition that causes bile ducts to become inflamed and scarred, characterized by alternating strictures and dilation of the bile ducts.

Antimitochondrial antibodies (AMA) are typically found in people with primary biliary cholangitis (PBC).

PBC is often linked with other autoimmune diseases.

Ursodiol is commonly used to treat PBC.

Gallstones are a common cause of secondary biliary cirrhosis.

Secondary biliary cirrhosis results from elevated bile pressure and resulting liver injury and scarring.

Primary biliary cholangitis (PBC) is more common in females.

Biliary cirrhosis is a common complication of primary sclerosing cholangitis (PSC).

Perinuclear antineutrophil cytoplasmic antibody (p-ANCA) is a common autoantibody associated with PSC.

Primary sclerosing cholangitis has concentric "onion skin" bile duct fibrosis with alternating strictures and dilation of intra- and extrahepatic bile ducts.

Primary sclerosing cholangitis (PSC) is associated with ulcerative colitis.

PBC causes an autoimmune reaction that leads to the gradual destruction of the lobular bile ducts.

PBC is often seen in middle-aged women.

Secondary biliary cirrhosis arises from extrahepatic biliary obstruction and increased pressure in intrahepatic ducts.

Secondary biliary cirrhosis typically involves known obstructive lesions like gallstones and biliary strictures.

Symptoms of biliary tract disease can involve pruritus, jaundice, dark urine, light-colored stools, and hepatosplenomegaly.

Biliary tract disease is recognized by a cholestatic pattern of liver function tests (LFTs) - elevated conjugated bilirubin, cholesterol, ALP, and GGT.

Primary biliary cholangitis is linked to autoimmune disorders, such as Hashimoto's thyroiditis and rheumatoid arthritis.

Primary sclerosing cholangitis can lead to secondary biliary cirrhosis, and increase risk of cholangiocarcinoma and gallbladder cancer.

Abdominal pain is a common symptom in biliary tract disease

A typical liver function test (LFT) change in biliary tract disease involves elevated conjugated bilirubin and alkaline phosphatase (ALP).

Primary sclerosing cholangitis is characterized by concentric, 'onion-skin' bile duct fibrosis.