Biliary Tract Diseases and Primary Sclerosing Cholangitis
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Questions and Answers

Which pattern of liver function tests (LFTs) is typically seen in biliary tract disease?

  • Elevated unconjugated bilirubin
  • Elevated cholesterol
  • Elevated gamma-glutamyl transferase (GGT)
  • Elevated alkaline phosphatase (ALP) (correct)
  • What is the classic presentation of primary sclerosing cholangitis?

  • Antimitochondrial antibody positivity
  • Middle-aged males with ulcerative colitis
  • Pruritus and jaundice
  • Alternating strictures and dilation of bile ducts (correct)
  • Which autoantibody is typically positive in primary biliary cholangitis?

  • Anti-smooth muscle antibody
  • Antinuclear antibody
  • Anti-liver kidney microsomal antibody
  • Antimitochondrial antibody (correct)
  • Which condition is associated with primary biliary cholangitis?

    <p>All of the above</p> Signup and view all the answers

    What is the treatment for primary biliary cholangitis?

    <p>Ursodiol</p> Signup and view all the answers

    What is the most common cause of secondary biliary cirrhosis?

    <p>Gallstones</p> Signup and view all the answers

    What is the pathophysiology of secondary biliary cirrhosis?

    <p>Elevated bile pressure and injury/fibrosis</p> Signup and view all the answers

    Which gender is most commonly affected by primary biliary cholangitis?

    <p>Females</p> Signup and view all the answers

    What is the most common complication of primary sclerosing cholangitis?

    <p>Biliary cirrhosis</p> Signup and view all the answers

    Which autoantibody is typically positive in primary sclerosing cholangitis?

    <p>Perinuclear antineutrophil cytoplasmic antibody (p-ANCA)</p> Signup and view all the answers

    Which condition is characterized by concentric 'onion skin' bile duct fibrosis and alternating strictures and dilation of intra- and extrahepatic bile ducts?

    <p>Primary sclerosing cholangitis</p> Signup and view all the answers

    Which condition is associated with ulcerative colitis?

    <p>Primary sclerosing cholangitis</p> Signup and view all the answers

    Which condition is characterized by autoimmune reaction leading to destruction of lobular bile ducts?

    <p>Primary biliary cholangitis</p> Signup and view all the answers

    Which condition is typically seen in middle-aged females?

    <p>Primary biliary cholangitis</p> Signup and view all the answers

    Which condition is characterized by extrahepatic biliary obstruction and increased pressure in intrahepatic ducts?

    <p>Secondary biliary cirrhosis</p> Signup and view all the answers

    Which condition is associated with known obstructive lesions such as gallstones and biliary strictures?

    <p>Secondary biliary cirrhosis</p> Signup and view all the answers

    Which condition may present with pruritus, jaundice, dark urine, light-colored stool, and hepatosplenomegaly?

    <p>Biliary tract disease</p> Signup and view all the answers

    Which condition is characterized by a cholestatic pattern of liver function tests (LFTs) with increased conjugated bilirubin, cholesterol, ALP, and GGT?

    <p>Biliary tract disease</p> Signup and view all the answers

    Which condition is associated with other autoimmune conditions such as Hashimoto thyroiditis and rheumatoid arthritis?

    <p>Primary biliary cholangitis</p> Signup and view all the answers

    Which condition can lead to secondary biliary cirrhosis and an increased risk of cholangiocarcinoma and gallbladder cancer?

    <p>Primary sclerosing cholangitis</p> Signup and view all the answers

    Which of the following symptoms is commonly seen in biliary tract disease?

    <p>Abdominal pain</p> Signup and view all the answers

    Which liver function test (LFT) pattern is typically observed in biliary tract disease?

    <p>Increased conjugated bilirubin and ALP</p> Signup and view all the answers

    Which of the following conditions is characterized by concentric 'onion skin' bile duct fibrosis and alternating strictures and dilation of intra- and extrahepatic bile ducts?

    <p>Primary sclerosing cholangitis</p> Signup and view all the answers

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