Podcast
Questions and Answers
What is the first-line choice with therapeutic lifestyle changes for patients with underlying risk factors like kidney function and liver disease?
What is the first-line choice with therapeutic lifestyle changes for patients with underlying risk factors like kidney function and liver disease?
In which group of patients is metformin contraindicated due to the risk of lactic acidosis?
In which group of patients is metformin contraindicated due to the risk of lactic acidosis?
How should metformin be taken to minimize gastrointestinal adverse effects?
How should metformin be taken to minimize gastrointestinal adverse effects?
Which factor can temporarily warrant the discontinuation of metformin due to the risk of lactic acidosis?
Which factor can temporarily warrant the discontinuation of metformin due to the risk of lactic acidosis?
Signup and view all the answers
What is a predisposing factor that would make a patient unsuitable for metformin therapy?
What is a predisposing factor that would make a patient unsuitable for metformin therapy?
Signup and view all the answers
What is the mechanism of action of sulfonylureas and non-sulfonylureas in increasing insulin secretion?
What is the mechanism of action of sulfonylureas and non-sulfonylureas in increasing insulin secretion?
Signup and view all the answers
Which receptors do thiazolidinediones (TZDs) primarily act on?
Which receptors do thiazolidinediones (TZDs) primarily act on?
Signup and view all the answers
What is the main therapeutic effect of sulfonylureas and non-sulfonylureas?
What is the main therapeutic effect of sulfonylureas and non-sulfonylureas?
Signup and view all the answers
What side effect is commonly associated with sulfonylureas?
What side effect is commonly associated with sulfonylureas?
Signup and view all the answers
Which of the following is a first-generation sulfonylurea drug that is rarely used?
Which of the following is a first-generation sulfonylurea drug that is rarely used?
Signup and view all the answers
How do sulfonylureas and non-sulfonylureas affect glucose-stimulated insulin secretion?
How do sulfonylureas and non-sulfonylureas affect glucose-stimulated insulin secretion?
Signup and view all the answers
What is the mechanism of action of GLP-1 receptor agonists?
What is the mechanism of action of GLP-1 receptor agonists?
Signup and view all the answers
Which of the following is a therapeutic effect of GLP-1 receptor agonists?
Which of the following is a therapeutic effect of GLP-1 receptor agonists?
Signup and view all the answers
What is an adverse effect commonly associated with GLP-1 receptor agonists?
What is an adverse effect commonly associated with GLP-1 receptor agonists?
Signup and view all the answers
Which GLP-1 receptor agonist is approved for the treatment of obesity?
Which GLP-1 receptor agonist is approved for the treatment of obesity?
Signup and view all the answers
What is an important administration consideration for GLP-1 receptor agonists?
What is an important administration consideration for GLP-1 receptor agonists?
Signup and view all the answers
Which patients might benefit from GLP-1 receptor agonists in terms of cardiovascular risk according to the text?
Which patients might benefit from GLP-1 receptor agonists in terms of cardiovascular risk according to the text?
Signup and view all the answers
What is the main contraindication for using DPP-4 inhibitors like Sitagliptin?
What is the main contraindication for using DPP-4 inhibitors like Sitagliptin?
Signup and view all the answers
Which organ is targeted for therapy in Type 2 Diabetes Mellitus?
Which organ is targeted for therapy in Type 2 Diabetes Mellitus?
Signup and view all the answers
What is the mechanism of action of DPP-4 inhibitors like Alogliptin?
What is the mechanism of action of DPP-4 inhibitors like Alogliptin?
Signup and view all the answers
Which of the following is a therapeutic effect of DPP-4 inhibitors like Linagliptin?
Which of the following is a therapeutic effect of DPP-4 inhibitors like Linagliptin?
Signup and view all the answers
What common adverse effect is associated with DPP-4 inhibitors like Saxagliptin?
What common adverse effect is associated with DPP-4 inhibitors like Saxagliptin?
Signup and view all the answers
Why are DPP-4 inhibitors like Sitagliptin considered well-tolerated in general?
Why are DPP-4 inhibitors like Sitagliptin considered well-tolerated in general?
Signup and view all the answers
Which type of cellular activity does metformin impact?
Which type of cellular activity does metformin impact?
Signup and view all the answers
Which class of medications act by selectively inhibiting the enzyme responsible for breaking down complex carbohydrates in the GI tract?
Which class of medications act by selectively inhibiting the enzyme responsible for breaking down complex carbohydrates in the GI tract?
Signup and view all the answers
In patients with T2DM, which medication class is associated with a potential risk of hypoglycemia if cleared by the kidneys?
In patients with T2DM, which medication class is associated with a potential risk of hypoglycemia if cleared by the kidneys?
Signup and view all the answers
What is the primary metabolic effect observed with GLP-1 agonists and SGLT2 inhibitors?
What is the primary metabolic effect observed with GLP-1 agonists and SGLT2 inhibitors?
Signup and view all the answers
Which type of disease is a contraindication for the use of metformin due to the risk of lactic acidosis?
Which type of disease is a contraindication for the use of metformin due to the risk of lactic acidosis?
Signup and view all the answers
What is a notable cancer concern associated with GLP-1 agonists in diabetic patients?
What is a notable cancer concern associated with GLP-1 agonists in diabetic patients?
Signup and view all the answers