Podcast
Questions and Answers
What is the first-line choice with therapeutic lifestyle changes for patients with underlying risk factors like kidney function and liver disease?
What is the first-line choice with therapeutic lifestyle changes for patients with underlying risk factors like kidney function and liver disease?
- Biguanides (correct)
- Sulfonylureas
- Thiazolidinediones
- Incretin mimetics
In which group of patients is metformin contraindicated due to the risk of lactic acidosis?
In which group of patients is metformin contraindicated due to the risk of lactic acidosis?
- Patients with well-controlled diabetes
- Patients with no underlying health conditions
- Patients with severe renal impairment (correct)
- Patients with mild liver disease
How should metformin be taken to minimize gastrointestinal adverse effects?
How should metformin be taken to minimize gastrointestinal adverse effects?
- Take with food (correct)
- Take on an empty stomach
- Titrate quickly
- Start with a high dose
Which factor can temporarily warrant the discontinuation of metformin due to the risk of lactic acidosis?
Which factor can temporarily warrant the discontinuation of metformin due to the risk of lactic acidosis?
What is a predisposing factor that would make a patient unsuitable for metformin therapy?
What is a predisposing factor that would make a patient unsuitable for metformin therapy?
What is the mechanism of action of sulfonylureas and non-sulfonylureas in increasing insulin secretion?
What is the mechanism of action of sulfonylureas and non-sulfonylureas in increasing insulin secretion?
Which receptors do thiazolidinediones (TZDs) primarily act on?
Which receptors do thiazolidinediones (TZDs) primarily act on?
What is the main therapeutic effect of sulfonylureas and non-sulfonylureas?
What is the main therapeutic effect of sulfonylureas and non-sulfonylureas?
What side effect is commonly associated with sulfonylureas?
What side effect is commonly associated with sulfonylureas?
Which of the following is a first-generation sulfonylurea drug that is rarely used?
Which of the following is a first-generation sulfonylurea drug that is rarely used?
How do sulfonylureas and non-sulfonylureas affect glucose-stimulated insulin secretion?
How do sulfonylureas and non-sulfonylureas affect glucose-stimulated insulin secretion?
What is the mechanism of action of GLP-1 receptor agonists?
What is the mechanism of action of GLP-1 receptor agonists?
Which of the following is a therapeutic effect of GLP-1 receptor agonists?
Which of the following is a therapeutic effect of GLP-1 receptor agonists?
What is an adverse effect commonly associated with GLP-1 receptor agonists?
What is an adverse effect commonly associated with GLP-1 receptor agonists?
Which GLP-1 receptor agonist is approved for the treatment of obesity?
Which GLP-1 receptor agonist is approved for the treatment of obesity?
What is an important administration consideration for GLP-1 receptor agonists?
What is an important administration consideration for GLP-1 receptor agonists?
Which patients might benefit from GLP-1 receptor agonists in terms of cardiovascular risk according to the text?
Which patients might benefit from GLP-1 receptor agonists in terms of cardiovascular risk according to the text?
What is the main contraindication for using DPP-4 inhibitors like Sitagliptin?
What is the main contraindication for using DPP-4 inhibitors like Sitagliptin?
Which organ is targeted for therapy in Type 2 Diabetes Mellitus?
Which organ is targeted for therapy in Type 2 Diabetes Mellitus?
What is the mechanism of action of DPP-4 inhibitors like Alogliptin?
What is the mechanism of action of DPP-4 inhibitors like Alogliptin?
Which of the following is a therapeutic effect of DPP-4 inhibitors like Linagliptin?
Which of the following is a therapeutic effect of DPP-4 inhibitors like Linagliptin?
What common adverse effect is associated with DPP-4 inhibitors like Saxagliptin?
What common adverse effect is associated with DPP-4 inhibitors like Saxagliptin?
Why are DPP-4 inhibitors like Sitagliptin considered well-tolerated in general?
Why are DPP-4 inhibitors like Sitagliptin considered well-tolerated in general?
Which type of cellular activity does metformin impact?
Which type of cellular activity does metformin impact?
Which class of medications act by selectively inhibiting the enzyme responsible for breaking down complex carbohydrates in the GI tract?
Which class of medications act by selectively inhibiting the enzyme responsible for breaking down complex carbohydrates in the GI tract?
In patients with T2DM, which medication class is associated with a potential risk of hypoglycemia if cleared by the kidneys?
In patients with T2DM, which medication class is associated with a potential risk of hypoglycemia if cleared by the kidneys?
What is the primary metabolic effect observed with GLP-1 agonists and SGLT2 inhibitors?
What is the primary metabolic effect observed with GLP-1 agonists and SGLT2 inhibitors?
Which type of disease is a contraindication for the use of metformin due to the risk of lactic acidosis?
Which type of disease is a contraindication for the use of metformin due to the risk of lactic acidosis?
What is a notable cancer concern associated with GLP-1 agonists in diabetic patients?
What is a notable cancer concern associated with GLP-1 agonists in diabetic patients?
