Podcast
Questions and Answers
Which of the following laboratory tests is used to assess the severity of anemia in a beta-thalassemia intermedia patient?
Which of the following laboratory tests is used to assess the severity of anemia in a beta-thalassemia intermedia patient?
Fecal stercobilinogen levels are normal in patients with beta-thalassemia major.
Fecal stercobilinogen levels are normal in patients with beta-thalassemia major.
What is the primary therapeutic intervention for patients with beta-thalassemia major?
What is the primary therapeutic intervention for patients with beta-thalassemia major?
Which type of hemoglobin is primarily found in adults?
Which type of hemoglobin is primarily found in adults?
The presence of ______ nucleated red blood cells (NRBCs) in a peripheral blood smear points to a more severe form of beta-thalassemia.
The presence of ______ nucleated red blood cells (NRBCs) in a peripheral blood smear points to a more severe form of beta-thalassemia.
Hemoglobinopathies are only symptomatic when an individual carries two copies of the abnormal gene.
Hemoglobinopathies are only symptomatic when an individual carries two copies of the abnormal gene.
Match the following laboratory findings with their corresponding condition:
Match the following laboratory findings with their corresponding condition:
What are the two main categories of hemoglobinopathies?
What are the two main categories of hemoglobinopathies?
Thalassemia is characterized by a reduction or absence of the production of the ______ chains.
Thalassemia is characterized by a reduction or absence of the production of the ______ chains.
Match the following types of hemoglobin with their corresponding globin chain composition:
Match the following types of hemoglobin with their corresponding globin chain composition:
Which of the following conditions is NOT a hemoglobinopathy?
Which of the following conditions is NOT a hemoglobinopathy?
Individuals carrying a defective gene for hemoglobinopathies are always protected from malaria.
Individuals carrying a defective gene for hemoglobinopathies are always protected from malaria.
What is the primary reason for the high prevalence of hemoglobinopathies in certain areas of the world?
What is the primary reason for the high prevalence of hemoglobinopathies in certain areas of the world?
What are the characteristic lab findings in β-thalassemia minor? (Select all that apply)
What are the characteristic lab findings in β-thalassemia minor? (Select all that apply)
In β-thalassemia major, there is a complete absence of HbA.
In β-thalassemia major, there is a complete absence of HbA.
What are the two main types of β-thalassemia?
What are the two main types of β-thalassemia?
The characteristic ‘hair-on-end’ appearance in β-thalassemia major is a result of ______ of the skull.
The characteristic ‘hair-on-end’ appearance in β-thalassemia major is a result of ______ of the skull.
Match the clinical features of β-thalassemia major with their underlying causes.
Match the clinical features of β-thalassemia major with their underlying causes.
Which of the following lab tests is considered the 'gold standard' for diagnosing β-thalassemia?
Which of the following lab tests is considered the 'gold standard' for diagnosing β-thalassemia?
β-thalassemia minor is typically asymptomatic and does not require treatment.
β-thalassemia minor is typically asymptomatic and does not require treatment.
What is the recommended treatment for iron overload in β-thalassemia major?
What is the recommended treatment for iron overload in β-thalassemia major?
Which of the following statements accurately describes the pathophysiology of thalassemia?
Which of the following statements accurately describes the pathophysiology of thalassemia?
Thalassemia is an autosomal dominant condition.
Thalassemia is an autosomal dominant condition.
What are the two most common types of thalassemia?
What are the two most common types of thalassemia?
The clinical severity of alpha-thalassemia is directly related to the number of ___________ that have been deleted.
The clinical severity of alpha-thalassemia is directly related to the number of ___________ that have been deleted.
Match the following alpha-thalassemia genotypes with their corresponding clinical presentations:
Match the following alpha-thalassemia genotypes with their corresponding clinical presentations:
Which of the following findings would you expect to see in a complete blood count (CBC) of an individual with alpha-thalassemia trait (minor)?
Which of the following findings would you expect to see in a complete blood count (CBC) of an individual with alpha-thalassemia trait (minor)?
Individuals with Hb H disease typically experience a mild form of alpha-thalassemia.
Individuals with Hb H disease typically experience a mild form of alpha-thalassemia.
What is the characteristic Hb variant found in Hb H disease?
What is the characteristic Hb variant found in Hb H disease?
What is the primary cause of Hb H disease?
What is the primary cause of Hb H disease?
Hb Bart's is the primary hemoglobin variant found in Hydrops fetalis.
Hb Bart's is the primary hemoglobin variant found in Hydrops fetalis.
What is the name of the blood film staining method used to identify Hb H cells after incubation with new methylene blue?
What is the name of the blood film staining method used to identify Hb H cells after incubation with new methylene blue?
In β-thalassemia, excess α-chains precipitate in erythroblasts, leading to ______ erythropoiesis.
In β-thalassemia, excess α-chains precipitate in erythroblasts, leading to ______ erythropoiesis.
Match the following terms with their corresponding definitions:
Match the following terms with their corresponding definitions:
The CBC parameter most helpful in differentiating iron deficiency anemia from thalassemia is the RDW.
The CBC parameter most helpful in differentiating iron deficiency anemia from thalassemia is the RDW.
Which of the following blood film findings are commonly observed in thalassemia?
Which of the following blood film findings are commonly observed in thalassemia?
What is the main difference between Hb H disease and Hydrops fetalis?
What is the main difference between Hb H disease and Hydrops fetalis?
What is the clinical syndrome associated with a 4 gene deletion in thalassemias?
What is the clinical syndrome associated with a 4 gene deletion in thalassemias?
A 1 gene deletion in thalassemias results in thalassemia major.
A 1 gene deletion in thalassemias results in thalassemia major.
What blood picture is associated with heterozygous β thalassemia?
What blood picture is associated with heterozygous β thalassemia?
A 3 gene deletion in thalassemia leads to _____ disease.
A 3 gene deletion in thalassemia leads to _____ disease.
Match the following thalassemia types with their characteristics:
Match the following thalassemia types with their characteristics:
In which type of thalassemia is iron overload a concern?
In which type of thalassemia is iron overload a concern?
A patient with α thalassaemia trait will always present with anaemia.
A patient with α thalassaemia trait will always present with anaemia.
What type of thalassemia is represented by homozygous genotype?
What type of thalassemia is represented by homozygous genotype?
Flashcards
Thalassemia
Thalassemia
A group of disorders with reduced globin chain production, leading to anemia.
Alpha Thalassemia
Alpha Thalassemia
A type of thalassemia with low synthesis of alpha chains.
Beta Thalassemia
Beta Thalassemia
A type of thalassemia with low synthesis of beta chains.
Hemoglobinopathies
Hemoglobinopathies
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Prevalence in UAE
Prevalence in UAE
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Qualitative Hemoglobinopathies
Qualitative Hemoglobinopathies
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Quantitative Hemoglobinopathies
Quantitative Hemoglobinopathies
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Hemoglobin F
Hemoglobin F
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Nucleated RBC's
Nucleated RBC's
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Lab findings in β-Thalassemia Major
Lab findings in β-Thalassemia Major
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Treatment options for β-Thalassemia Major
Treatment options for β-Thalassemia Major
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β-Thalassemia Intermedia
β-Thalassemia Intermedia
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Eventual future treatment
Eventual future treatment
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β-Thalassemia
β-Thalassemia
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β-Thalassemia trait (minor)
β-Thalassemia trait (minor)
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Symptoms of β-Thalassemia minor
Symptoms of β-Thalassemia minor
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β-Thalassemia Major
β-Thalassemia Major
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Clinical features of β-Thalassemia Major
Clinical features of β-Thalassemia Major
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Iron overload consequences
Iron overload consequences
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Lab diagnosis of β-Thalassemia Major
Lab diagnosis of β-Thalassemia Major
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Hb electrophoresis findings
Hb electrophoresis findings
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Hb H
Hb H
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Hb Bart's
Hb Bart's
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Poikilocytosis
Poikilocytosis
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α:β ratio
α:β ratio
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Hb H disease
Hb H disease
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Hydrops fetalis
Hydrops fetalis
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Microcytic Hypochromic Anemia
Microcytic Hypochromic Anemia
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Blood Film Findings
Blood Film Findings
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Haemoglobin Bart's
Haemoglobin Bart's
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Alpha thalassaemia trait
Alpha thalassaemia trait
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Beta thalassaemia major
Beta thalassaemia major
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Beta thalassaemia minor
Beta thalassaemia minor
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Thalassaemia intermediate
Thalassaemia intermediate
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Hb Lepore
Hb Lepore
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