27 Questions
What is the mechanism of action of penicillins?
Inhibition of transpeptidation reaction by binding to PBPs
Which bacteria are commonly targeted by antipseudomonal penicillins?
Pseudomonas aeruginosa and Klebsiella pneumoniae
What is the spectrum of activity of aminopenicillins?
Primarily gram-positive bacteria
What is the target site of cephalosporins' action?
Inhibition of transpeptidation by binding to PBPs
Which type of killing is associated with bactericidal antibiotics like penicillins and cephalosporins?
Time-dependent killing
What mechanism of resistance to vancomycin is attributed to VRSA?
Modification of vancomycin binding site
Which antibiotic has a spectrum of activity that includes MRSA, VISA, and VRSA?
Daptomycin
Which antibiotic is known for its unintended effects such as myopathy, rhabdomyolysis, and jaundice?
Cycloserine
What is the primary mechanism of action of polymyxin B?
Disruption of bacterial cell membranes
Which antibiotic is specifically mentioned for treating acute cystitis and urinary tract infections caused by E. coli and Enterococcus faecalis?
Fosfomycin
Which antibiotic acts by inhibiting the incorporation of amino acids into the bacterial cell wall?
Bacitracin
Which of the following statements about penicillins is correct?
Standard penicillins, antistaphylococcal penicillins, and extended-spectrum penicillins are all types of penicillins.
Which route of administration is NOT mentioned for penicillin G in the text?
Oral
Based on the information provided, which of the following statements is true about benzathine penicillin G suspension?
It is a depot formulation administered intramuscularly.
Which of the following penicillins is specifically mentioned as being available for oral administration?
Penicillin V
Which cephalosporin is specifically indicated for infections caused by MRSA, VISA, and VRSA?
Ceftaroline fosamil (Teflaro)
Which cephalosporin is effective against Neisseria gonorrhoeae and used in the treatment of gonorrhea?
Cefixime (Suprax)
Which cephalosporin is known for its extended gram-negative activity and is classified as 3rd generation?
Ceftriaxone
Which subclass of 2nd generation cephalosporins include antibiotics like Cefoxitin and Cefotetan?
Cephamycins
Which cephalosporin has the broadest spectrum of activity among cephalosporins and is specifically effective against Pseudomonas, Enterobacter, and Bacteroides?
Cefepime (Maxipime)
Which generation of cephalosporins includes antibiotics like Cefprozil and Cefuroxime axetil, with a spectrum of activity covering Haemophilus influenzae and Moraxella catarrhalis?
1st generation cephalosporins
Which mechanism of antibiotic resistance is NOT mentioned in the text?
Ribosome modification
What is the primary reason for the contraindication of β-lactam antibiotics, besides previous β-lactam allergy?
Reduced renal function
Which of the following is NOT a characteristic of carbapenem antibiotics as described in the text?
Not cross-allergenic with other β-lactams
What is the primary mechanism of action of vancomycin, as described in the text?
All of the above
Which of the following is NOT a spectrum of activity or use for vancomycin, as described in the text?
Treatment of Gram-negative bacterial infections
What is the primary route of administration for vancomycin when used for systemic Gram-positive infections, according to the text?
Intravenous
Review indications, contraindications, interactions, physiological action, unintended effects, and drug resistance mechanisms of beta-lactam and other cell wall- and membrane-active antibiotics.
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