Beta-Lactamase inhibitors

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Questions and Answers

Which of the following is NOT a beta-lactamase inhibitor?

  • Clavulanic acid
  • Sulbactam
  • Tazobactam
  • Amoxicillin (correct)

What is the rank of beta-lactamase inhibitors in the WHO list of medically important antimicrobials?

Not applicable

Beta lactamase inhibitors can be used with Beta-lactams/aminoglycosides combination

True (A)

Beta-lactamase inhibitors are primarily used to:

<p>Inactivate bacterial ß-lactamase enzymes (C)</p> Signup and view all the answers

The oral bioavailability of clavulanic acid is fixed in dogs

<p>False (B)</p> Signup and view all the answers

Which of the following describes the distribution of clavulanic acid?

<p>Vd: moderate (B)</p> Signup and view all the answers

What is the primary route of elimination for clavulanic acid in dogs?

<p>Renal excretion (A)</p> Signup and view all the answers

Beta-lactamase inhibitors do NOT inactivate:

<p>Extended-spectrum beta-lactamases (ESBLs) (C)</p> Signup and view all the answers

Beta-lactamase inhibitors DO inactivate:

<p>Penicillinase (A), Some cephalosporinase (B)</p> Signup and view all the answers

Most Beta lactamase are synthesized by aerobes

<p>False (B)</p> Signup and view all the answers

What is the ratio of β-lactam antibiotic to clavulanic acid or sulbactam in susceptibility disks?

<p>2:1 (B)</p> Signup and view all the answers

Why might susceptibility testing not accurately predict the efficacy of β-lactamase inhibitors?

<p>The in vivo drug concentrations may not correspond to the tested ratio (B)</p> Signup and view all the answers

Which of the following β-lactamase inhibitor combinations is available only in oral formulations for humans and small animals?

<p>Amoxicillin-clavulanic acid (A)</p> Signup and view all the answers

Which β-lactamase inhibitor formulation is used in the treatment of sepsis in small animals?

<p>Sodium ampicillin-sulbactam (B), Ampicillin-sulbactam (C)</p> Signup and view all the answers

Sodium ampicillin-sulbactam and Carcillin-clavulanic acid are also used in the treatment of sepsis in valuable foals

<p>True (A)</p> Signup and view all the answers

Amoxicillin-clavulanic acid is a first-line drug in small animals for treating infections caused by:

<p>β-lactamase producing Staphylococci (B)</p> Signup and view all the answers

Which of the following formulations are available for human uses in the U.S. and Canada?

<p>Sodium ampicillin-sulbactam (C), Acarcillin disodium-clavulanic acid (D)</p> Signup and view all the answers

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