15 Questions
Match the antibiotic with its mechanism of action:
Tetracycline = Inhibits protein synthesis by blocking the binding of aminoacyl tRNA to the A site on the ribosome Neomycin = Acts directly on the bacterial ribosome to inhibit the initiation of protein synthesis Bacitracin = Cell wall synthesis inhibitors, against gram-positives Vancomycin = Prevents cross-linking of peptidoglycan cell wall
Match the antibiotic with its source:
Tetracycline = Synthetic or semisynthetic compounds Neomycin = Isolated from Streptomyces Bacitracin = Polypeptide antibiotics Vancomycin = Glycopeptide antibiotic
Match the antibiotic with its target bacteria:
Tetracycline = Aerobic, gram-negative bacteria Neomycin = Aerobic, gram-negative bacilli Bacitracin = Gram-positives Vancomycin = Antibiotic-resistant S.aureus
Match the antibiotic with its primary usage:
Tetracycline = Broad-spectrum antibiotic Neomycin = Potent bactericidal antibiotic Bacitracin = Topical application, against gram-positives Vancomycin = Important 'last line' against antibiotic-resistant S.aureus
Match the antibiotic with its route of administration:
Tetracycline = Well absorbed orally Neomycin = Cannot safely be used systemically Bacitracin = Topical application Vancomycin = Varies, including intravenous administration
Match the tetracycline antibiotic with its mechanism of action:
Doxycycline = Inhibits protein synthesis by binding to the 30S ribosomal subunit Minocycline = Blocks protein synthesis by binding to the 30S ribosomal subunit Tetracycline = Interferes with protein synthesis by binding to the 30S ribosomal subunit Demeclocycline = Disrupts protein production by binding to the 30S ribosomal subunit
Match the tetracycline antibiotic with its primary usage:
Doxycycline = Treatment of acne and respiratory tract infections Minocycline = Prescribed for acne and bacterial infections Tetracycline = Used for urinary tract infections and gonorrhea Demeclocycline = Treatment of Lyme disease and pneumonia
Match the tetracycline antibiotic with its target bacteria:
Doxycycline = Effective against Chlamydia and Mycoplasma species Minocycline = Targets Staphylococcus aureus and Streptococcus pneumoniae Tetracycline = Acts on Escherichia coli and Haemophilus influenzae Demeclocycline = Targets Neisseria gonorrhoeae and Rickettsia
Match the tetracycline antibiotic with its mechanism of action:
Tetracycline = Inhibits protein synthesis by blocking the binding of aminoacyl tRNA to the A site on the ribosome Doxycycline = Inhibits protein synthesis by blocking the binding of aminoacyl tRNA to the A site on the ribosome Minocycline = Inhibits protein synthesis by blocking the binding of aminoacyl tRNA to the A site on the ribosome Glycylcycline = Inhibits protein synthesis by blocking the binding of aminoacyl tRNA to the A site on the ribosome
Match the tetracycline antibiotic with its primary usage:
Tetracycline = Treatment of bacterial diseases Doxycycline = Treatment of bacterial diseases Minocycline = Treatment of bacterial diseases Glycylcycline = Treatment of bacterial diseases
Match the tetracycline antibiotic with its route of administration:
Tetracycline = Orally absorbed well Doxycycline = Orally absorbed well Minocycline = Orally absorbed well Glycylcycline = Orally absorbed well
Match the antibiotic with its primary usage:
Clavulanic acid = Beta-lactamase inhibitor Amoxicillin = Combined with clavulanic acid as clavamox or augmentin Cephalosporins = Used as penicillin substitutes against Gram-negative bacteria and in surgical prophylaxis Tetracyclines = Broad-spectrum antibiotics with a wide range of activity against both Gram-positive and Gram-negative bacteria
Match the antibiotic with its mechanism of action:
Clavulanic acid = Irreversible, 'suicide' inhibitor of beta-lactamase Amoxicillin = Inactivation by bacterial beta-lactamases Cephalosporins = Prevents cell wall synthesis by binding to penicillin binding proteins (PBPs) Tetracyclines = Bacteriostatic compounds
Match the antibiotic with its target bacteria:
Clavulanic acid = Bacteria that produce beta-lactamase enzymes Amoxicillin = Wide range of bacteria including Gram-positive and Gram-negative bacteria Cephalosporins = Gram-negative bacteria and some resistance to beta-lactamases from S.aureus Tetracyclines = Broad range including both Gram-positive and Gram-negative bacteria
Match the antibiotic with its resistance pattern:
Clavulanic acid = Overcoming resistance in bacteria that produce beta-lactamase enzymes Amoxicillin = Subject to degradation by some bacterial beta-lactamases Cephalosporins = Resistant to beta-lactamases from S.aureus Tetracyclines = Pseudomonas aeruginosa is less sensitive but generally susceptible to tetracycline concentrations
Test your knowledge about beta-lactamase inhibitors such as clavulanic acid and the pharmacological relationship and uses of Cephalosporins. Learn about the combination of clavulanic acid with antibiotics like amoxicillin to overcome bacterial resistance.
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