Podcast
Questions and Answers
In schizophrenia, the mesolimbic system shows an increase in dopamine, resulting in _______ symptoms.
In schizophrenia, the mesolimbic system shows an increase in dopamine, resulting in _______ symptoms.
positive
The mesocortical pathway in schizophrenia exhibits dopamine hypoactivity, leading to ______, ______, and ______ symptoms.
The mesocortical pathway in schizophrenia exhibits dopamine hypoactivity, leading to ______, ______, and ______ symptoms.
negative; cognitive; affective
The Nigrostriatal pathway experiences a decrease in dopamine and is associated with EPS (extrapyramidal side effects) and TD (tardive dyskinesia) drug side effects due to ________ in DA.
The Nigrostriatal pathway experiences a decrease in dopamine and is associated with EPS (extrapyramidal side effects) and TD (tardive dyskinesia) drug side effects due to ________ in DA.
decrease
In schizophrenia, the Tuberoinfundibular pathway demonstrates a decrease in dopamine, contributing to its ________.
In schizophrenia, the Tuberoinfundibular pathway demonstrates a decrease in dopamine, contributing to its ________.
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Risperidone requires dose adjustments for hepatic and ______ impairment
Risperidone requires dose adjustments for hepatic and ______ impairment
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Risperidone DDI with ______?
Risperidone DDI with ______?
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Risperidone warning for QTc ______
Risperidone warning for QTc ______
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Ziprasidone dosing and formulations? -twice a day -oral capsule, IM injection ______
Ziprasidone dosing and formulations? -twice a day -oral capsule, IM injection ______
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Which drug must you eat at least a 500 kcal meal to work? ______
Which drug must you eat at least a 500 kcal meal to work? ______
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Pimavanserine MOA? Inverse agonist and antagonist at 5-ht2a and 5-ht2c ______
Pimavanserine MOA? Inverse agonist and antagonist at 5-ht2a and 5-ht2c ______
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Clozapine is recommended to be offered after other options failed or persistent ________ or serious aggression or hostility.
Clozapine is recommended to be offered after other options failed or persistent ________ or serious aggression or hostility.
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Dose titration is required in ________.
Dose titration is required in ________.
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ANC formula: ANC = Total WBC count × (ABS neutrophils + ABS bands) X ________.
ANC formula: ANC = Total WBC count × (ABS neutrophils + ABS bands) X ________.
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Iloperidone is not recommended in severe ________ dysfunction.
Iloperidone is not recommended in severe ________ dysfunction.
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Lurasidone must be taken with a ________ kcal meal to improve bioavailability.
Lurasidone must be taken with a ________ kcal meal to improve bioavailability.
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Zyprexa relprevv has a black box warning for post injection delirium/sedation syndrome and facilities must have emergency response services readily available and continuous monitoring must be done ________ hours after dose.
Zyprexa relprevv has a black box warning for post injection delirium/sedation syndrome and facilities must have emergency response services readily available and continuous monitoring must be done ________ hours after dose.
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Olanzapine/samidorphan mechanism: u-opioid receptor antagonist - thought to help minimize weight gain associated with ________.
Olanzapine/samidorphan mechanism: u-opioid receptor antagonist - thought to help minimize weight gain associated with ________.
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Quetiapine is commonly used in ICU delirium and ________ disorders.
Quetiapine is commonly used in ICU delirium and ________ disorders.
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Typical antipsychotics primarily act as dopamine _________
Typical antipsychotics primarily act as dopamine _________
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When taking Quetiapine XR, it can be taken with or without ________.
When taking Quetiapine XR, it can be taken with or without ________.
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Atypical antipsychotics primarily act as dopamine and _________ antagonists
Atypical antipsychotics primarily act as dopamine and _________ antagonists
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Paliperidone is contraindicated in hypersensitivity to ________.
Paliperidone is contraindicated in hypersensitivity to ________.
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Quetiapine warnings and precautions include QTc prolongation and suicidal thoughts in ________.
Quetiapine warnings and precautions include QTc prolongation and suicidal thoughts in ________.
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It is recommended to optimize treatment with how many agents? _________
It is recommended to optimize treatment with how many agents? _________
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NMS symptoms include rigidity, hyperthermia, autonomic dysfunction, and altered _________ status
NMS symptoms include rigidity, hyperthermia, autonomic dysfunction, and altered _________ status
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Risperidone is available in oral tablet, ODT, SUBQ and ________ injection formulations.
Risperidone is available in oral tablet, ODT, SUBQ and ________ injection formulations.
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NMS occurs at _________ point in treatment
NMS occurs at _________ point in treatment
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Extrapyramidal symptoms include akathisia, dystonia, pseudo-parkinsonism, and tardive _________
Extrapyramidal symptoms include akathisia, dystonia, pseudo-parkinsonism, and tardive _________
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Akathisia presentation includes anxiety, restlessness, and irresistible urge to _________
Akathisia presentation includes anxiety, restlessness, and irresistible urge to _________
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Dystonia presentation includes sustained skeletal muscle contraction and _________
Dystonia presentation includes sustained skeletal muscle contraction and _________
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Pseudo-parkinsonism presentation includes rigidity, tremor, bradykinesia, and shuffled _________
Pseudo-parkinsonism presentation includes rigidity, tremor, bradykinesia, and shuffled _________
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Tardive dyskinesia presentation includes rhythmic involuntary _________
Tardive dyskinesia presentation includes rhythmic involuntary _________
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VMAT2 inhibitors include deutetrabenazine and _________
VMAT2 inhibitors include deutetrabenazine and _________
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Hyperprolactinemia short-term effects include menstrual disturbances, sexual dysfunction, and _________
Hyperprolactinemia short-term effects include menstrual disturbances, sexual dysfunction, and _________
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Benefits to LAIs include a significant reduced risk for psychiatric hospitalizations, any hospitalization, ER visits, risk of death by any cause, and suicide attempts. LAIs are helpful in cases of difficulty with ________.
Benefits to LAIs include a significant reduced risk for psychiatric hospitalizations, any hospitalization, ER visits, risk of death by any cause, and suicide attempts. LAIs are helpful in cases of difficulty with ________.
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The first line for acute agitation and aggression involves non-pharmacologic interventions and de-escalation techniques, while the second line includes ______ interventions.
The first line for acute agitation and aggression involves non-pharmacologic interventions and de-escalation techniques, while the second line includes ______ interventions.
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For acute agitation and aggression, oral antipsychotic options include haloperidol, aripiprazole, asenapine, risperidone, and ________.
For acute agitation and aggression, oral antipsychotic options include haloperidol, aripiprazole, asenapine, risperidone, and ________.
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Non-oral antipsychotics used for acute agitation and aggression may include haloperidol, droperidol, loxapine, olanzapine, and ________.
Non-oral antipsychotics used for acute agitation and aggression may include haloperidol, droperidol, loxapine, olanzapine, and ________.
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The formulation options for acute agitation and aggression from best to worst are PO > IM >> ______.
The formulation options for acute agitation and aggression from best to worst are PO > IM >> ______.
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Haloperidol Decanoate is a long-acting injection given every ______ weeks.
Haloperidol Decanoate is a long-acting injection given every ______ weeks.
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Haloperidol decanoate maintenance is usually 10X the oral dose and may require oral ______.
Haloperidol decanoate maintenance is usually 10X the oral dose and may require oral ______.
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Fluphenazine Deconate is a long-acting injection given every ______ weeks.
Fluphenazine Deconate is a long-acting injection given every ______ weeks.
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Fluphenazine decanoate has a short onset of action and oral overlap is ______ necessary.
Fluphenazine decanoate has a short onset of action and oral overlap is ______ necessary.
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Psychiatric hospitals must assess BMI, BP, blood glucose control, and lipid status within the past ______ for patients discharged with a prescription for an antipsychotic drug.
Psychiatric hospitals must assess BMI, BP, blood glucose control, and lipid status within the past ______ for patients discharged with a prescription for an antipsychotic drug.
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Aripiprazole's MOA involves dopamine and serotonin ______ agonist.
Aripiprazole's MOA involves dopamine and serotonin ______ agonist.
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Aripiprazole benefits include low risk of metabolic abnormalities, sexual dysfunction, and can decrease ______ levels.
Aripiprazole benefits include low risk of metabolic abnormalities, sexual dysfunction, and can decrease ______ levels.
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