46 Questions
In schizophrenia, the mesolimbic system shows an increase in dopamine, resulting in _______ symptoms.
positive
The mesocortical pathway in schizophrenia exhibits dopamine hypoactivity, leading to ______, ______, and ______ symptoms.
negative; cognitive; affective
The Nigrostriatal pathway experiences a decrease in dopamine and is associated with EPS (extrapyramidal side effects) and TD (tardive dyskinesia) drug side effects due to ________ in DA.
decrease
In schizophrenia, the Tuberoinfundibular pathway demonstrates a decrease in dopamine, contributing to its ________.
decrease
Risperidone requires dose adjustments for hepatic and ______ impairment
renal
Risperidone DDI with ______?
CYP2D6
Risperidone warning for QTc ______
prolongation
Ziprasidone dosing and formulations? -twice a day -oral capsule, IM injection ______
(immediate)
Which drug must you eat at least a 500 kcal meal to work? ______
ziprasidone
Pimavanserine MOA? Inverse agonist and antagonist at 5-ht2a and 5-ht2c ______
receptors
Clozapine is recommended to be offered after other options failed or persistent ________ or serious aggression or hostility.
suicidality
Dose titration is required in ________.
clozapine
ANC formula: ANC = Total WBC count × (ABS neutrophils + ABS bands) X ________.
1000
Iloperidone is not recommended in severe ________ dysfunction.
hepatic
Lurasidone must be taken with a ________ kcal meal to improve bioavailability.
350
Zyprexa relprevv has a black box warning for post injection delirium/sedation syndrome and facilities must have emergency response services readily available and continuous monitoring must be done ________ hours after dose.
3
Olanzapine/samidorphan mechanism: u-opioid receptor antagonist - thought to help minimize weight gain associated with ________.
olanzapine
Quetiapine is commonly used in ICU delirium and ________ disorders.
sleep
Typical antipsychotics primarily act as dopamine _________
antagonists
When taking Quetiapine XR, it can be taken with or without ________.
food
Atypical antipsychotics primarily act as dopamine and _________ antagonists
serotonin
Paliperidone is contraindicated in hypersensitivity to ________.
risperidone
Quetiapine warnings and precautions include QTc prolongation and suicidal thoughts in ________.
children
It is recommended to optimize treatment with how many agents? _________
one
NMS symptoms include rigidity, hyperthermia, autonomic dysfunction, and altered _________ status
mental
Risperidone is available in oral tablet, ODT, SUBQ and ________ injection formulations.
IM
NMS occurs at _________ point in treatment
any
Extrapyramidal symptoms include akathisia, dystonia, pseudo-parkinsonism, and tardive _________
dyskinesia
Akathisia presentation includes anxiety, restlessness, and irresistible urge to _________
move
Dystonia presentation includes sustained skeletal muscle contraction and _________
rigidity
Pseudo-parkinsonism presentation includes rigidity, tremor, bradykinesia, and shuffled _________
gait
Tardive dyskinesia presentation includes rhythmic involuntary _________
movements
VMAT2 inhibitors include deutetrabenazine and _________
valbenazine
Hyperprolactinemia short-term effects include menstrual disturbances, sexual dysfunction, and _________
gynecomastia
Benefits to LAIs include a significant reduced risk for psychiatric hospitalizations, any hospitalization, ER visits, risk of death by any cause, and suicide attempts. LAIs are helpful in cases of difficulty with ________.
adherence
The first line for acute agitation and aggression involves non-pharmacologic interventions and de-escalation techniques, while the second line includes ______ interventions.
pharmacologic
For acute agitation and aggression, oral antipsychotic options include haloperidol, aripiprazole, asenapine, risperidone, and ________.
olanzapine
Non-oral antipsychotics used for acute agitation and aggression may include haloperidol, droperidol, loxapine, olanzapine, and ________.
ziprasidone
The formulation options for acute agitation and aggression from best to worst are PO > IM >> ______.
IV
Haloperidol Decanoate is a long-acting injection given every ______ weeks.
4
Haloperidol decanoate maintenance is usually 10X the oral dose and may require oral ______.
overlap
Fluphenazine Deconate is a long-acting injection given every ______ weeks.
two
Fluphenazine decanoate has a short onset of action and oral overlap is ______ necessary.
not
Psychiatric hospitals must assess BMI, BP, blood glucose control, and lipid status within the past ______ for patients discharged with a prescription for an antipsychotic drug.
year
Aripiprazole's MOA involves dopamine and serotonin ______ agonist.
partial
Aripiprazole benefits include low risk of metabolic abnormalities, sexual dysfunction, and can decrease ______ levels.
prolactin
Learn about the benefits of Long-Acting Injectables (LAIs) for individuals struggling with adherence to medication. Explore the first-line and second-line treatment options for acute agitation and aggression, including non-pharmacological interventions and pharmacological choices.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free