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Questions and Answers
An increase in dopamine in the mesocortical pathway leads to positive symptoms of schizophrenia.
An increase in dopamine in the mesocortical pathway leads to positive symptoms of schizophrenia.
False
The Tuberoinfundibular pathway in schizophrenia shows an increase in dopamine levels.
The Tuberoinfundibular pathway in schizophrenia shows an increase in dopamine levels.
False
Dementia is one of the medical conditions that can present with psychosis.
Dementia is one of the medical conditions that can present with psychosis.
True
Schizophrenia onset typically begins around the age of 30.
Schizophrenia onset typically begins around the age of 30.
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Typical antipsychotics primarily act as serotonin agonists.
Typical antipsychotics primarily act as serotonin agonists.
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Atypical antipsychotics are considered first generation.
Atypical antipsychotics are considered first generation.
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Neuroleptic malignant syndrome (NMS) is not a medical emergency.
Neuroleptic malignant syndrome (NMS) is not a medical emergency.
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NMS symptoms include hypotension and hypoglycemia.
NMS symptoms include hypotension and hypoglycemia.
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Extrapyramidal symptoms include akathisia, dystonia, and tardive dyskinesia.
Extrapyramidal symptoms include akathisia, dystonia, and tardive dyskinesia.
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Akathisia usually presents with a slow onset over months to years.
Akathisia usually presents with a slow onset over months to years.
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Pseudo-parkinsonism symptoms include tremor, bradykinesia, and shuffled gait.
Pseudo-parkinsonism symptoms include tremor, bradykinesia, and shuffled gait.
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Tardive dyskinesia can occur within days to weeks of starting treatment.
Tardive dyskinesia can occur within days to weeks of starting treatment.
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Ziprasidone dosing includes once a day oral capsule and immediate IM injection.
Ziprasidone dosing includes once a day oral capsule and immediate IM injection.
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Pimavanserin is FDA approved for the treatment of Parkinson's Disease psychosis.
Pimavanserin is FDA approved for the treatment of Parkinson's Disease psychosis.
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VMAT2 inhibitors include haloperidol and aripiprazole.
VMAT2 inhibitors include haloperidol and aripiprazole.
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Iglami formulations include IV and subcutaneous injection.
Iglami formulations include IV and subcutaneous injection.
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Hyperprolactinemia due to dopamine antagonism can cause menstrual disturbances and gynecomastia.
Hyperprolactinemia due to dopamine antagonism can cause menstrual disturbances and gynecomastia.
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Risperidone long-acting injectable Perseris is given every two weeks.
Risperidone long-acting injectable Perseris is given every two weeks.
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Typical antipsychotics are mainly beneficial for reducing negative symptoms of schizophrenia.
Typical antipsychotics are mainly beneficial for reducing negative symptoms of schizophrenia.
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The main benefit of Ziprasidone is its high efficacy in treating metabolic syndrome.
The main benefit of Ziprasidone is its high efficacy in treating metabolic syndrome.
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Treatment-resistant schizophrenia is defined as a lack of symptom improvement despite trials of antipsychotics from the same class.
Treatment-resistant schizophrenia is defined as a lack of symptom improvement despite trials of antipsychotics from the same class.
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Lumateperon is recommended in severe hepatic impairment.
Lumateperon is recommended in severe hepatic impairment.
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Olanzapine/samidorphan dosing involves adding 5 mg of samidorphan to the standard olanzapine dose.
Olanzapine/samidorphan dosing involves adding 5 mg of samidorphan to the standard olanzapine dose.
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Haloperidol Decanoate is given every 2 weeks.
Haloperidol Decanoate is given every 2 weeks.
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Fluphenazine Decanoate has a long onset of action and oral overlap is necessary.
Fluphenazine Decanoate has a long onset of action and oral overlap is necessary.
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Quetiapine is commonly used in the treatment of ICU delirium and sleep disorders.
Quetiapine is commonly used in the treatment of ICU delirium and sleep disorders.
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Lurasidone must be taken on an empty stomach for optimal bioavailability.
Lurasidone must be taken on an empty stomach for optimal bioavailability.
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Aripiprazole is a full agonist of dopamine and serotonin receptors.
Aripiprazole is a full agonist of dopamine and serotonin receptors.
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Cariprazine has a moderate risk of weight gain compared to aripiprazole.
Cariprazine has a moderate risk of weight gain compared to aripiprazole.
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Asenapine sublingual tablet should be swallowed with water.
Asenapine sublingual tablet should be swallowed with water.
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Brexpiprazole has no dose adjustments needed in renal or hepatic impairment.
Brexpiprazole has no dose adjustments needed in renal or hepatic impairment.
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Paliperidone should be avoided in individuals with hypersensitivity to risperidone.
Paliperidone should be avoided in individuals with hypersensitivity to risperidone.
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Lurasidone is contraindicated with strong CYP3A4 inhibitors.
Lurasidone is contraindicated with strong CYP3A4 inhibitors.
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Haloperidol carries a high risk of sedation as an adverse effect.
Haloperidol carries a high risk of sedation as an adverse effect.
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Clozapine must be offered before considering other treatment options.
Clozapine must be offered before considering other treatment options.
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Fluphenazine formulations include oral tablet only.
Fluphenazine formulations include oral tablet only.
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Zyprexa Relprevv has a black box warning related to post-injection delirium/sedation syndrome.
Zyprexa Relprevv has a black box warning related to post-injection delirium/sedation syndrome.
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Aripiprazole can increase prolactin levels.
Aripiprazole can increase prolactin levels.
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Quetiapine should be taken on an empty stomach for best results.
Quetiapine should be taken on an empty stomach for best results.
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Asenapine patch should be worn for 48 hours before replacing with a new one.
Asenapine patch should be worn for 48 hours before replacing with a new one.
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Iloperidone interacts with CYP450 CYP2D6 CYP3A4 enzymes.
Iloperidone interacts with CYP450 CYP2D6 CYP3A4 enzymes.
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Haloperidol Decanoate maintenance dose is typically 5 times the oral dose.
Haloperidol Decanoate maintenance dose is typically 5 times the oral dose.
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BBW for Loxapine includes risk of QT prolongation.
BBW for Loxapine includes risk of QT prolongation.
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Which of the following substances is NOT listed as exacerbating psychosis in the text?
Which of the following substances is NOT listed as exacerbating psychosis in the text?
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What are the minimum number of the following required for a schizophrenia diagnosis according to the DSM-5?
What are the minimum number of the following required for a schizophrenia diagnosis according to the DSM-5?
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In the mesolimbic system, an increase in dopamine causes which type of symptoms in schizophrenia?
In the mesolimbic system, an increase in dopamine causes which type of symptoms in schizophrenia?
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Which pathway in schizophrenia shows a decrease in dopamine levels and is associated with extrapyramidal side effects (EPS) and Tardive Dyskinesia?
Which pathway in schizophrenia shows a decrease in dopamine levels and is associated with extrapyramidal side effects (EPS) and Tardive Dyskinesia?
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Which antipsychotic medication requires dose adjustments for both hepatic and renal impairment?
Which antipsychotic medication requires dose adjustments for both hepatic and renal impairment?
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What is the main warning associated with Risperidone use?
What is the main warning associated with Risperidone use?
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What is the primary benefit of Ziprasidone?
What is the primary benefit of Ziprasidone?
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What is the main treatment recommendation for individuals with treatment-resistant schizophrenia?
What is the main treatment recommendation for individuals with treatment-resistant schizophrenia?
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Atypical antipsychotics primarily antagonize which neurotransmitters?
Atypical antipsychotics primarily antagonize which neurotransmitters?
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What is a common short-term effect of hyperprolactinemia due to dopamine antagonism?
What is a common short-term effect of hyperprolactinemia due to dopamine antagonism?
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Which symptom is characteristic of pseudo-parkinsonism induced by antipsychotics?
Which symptom is characteristic of pseudo-parkinsonism induced by antipsychotics?
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What is the primary mechanism of action of typical antipsychotics?
What is the primary mechanism of action of typical antipsychotics?
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Which treatment is recommended for akathisia induced by antipsychotic medications?
Which treatment is recommended for akathisia induced by antipsychotic medications?
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What is the first-line treatment choice for individuals with schizophrenia?
What is the first-line treatment choice for individuals with schizophrenia?
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Which condition is a Black Box Warning associated with in all antipsychotic medications?
Which condition is a Black Box Warning associated with in all antipsychotic medications?
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Which treatment is used for the long-term management of tardive dyskinesia?
Which treatment is used for the long-term management of tardive dyskinesia?
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In what pathway does an increase in dopamine levels lead to positive symptoms of schizophrenia?
In what pathway does an increase in dopamine levels lead to positive symptoms of schizophrenia?
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What is the first-line treatment recommended for acute agitation and aggression?
What is the first-line treatment recommended for acute agitation and aggression?
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Which atypical antipsychotic is known for causing a high risk of extrapyramidal symptoms (EPS)?
Which atypical antipsychotic is known for causing a high risk of extrapyramidal symptoms (EPS)?
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How often is Haloperidol Decanoate typically administered?
How often is Haloperidol Decanoate typically administered?
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What is the black box warning associated with Loxapine?
What is the black box warning associated with Loxapine?
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Which atypical antipsychotic has a unique adverse effect of metallic taste and tongue numbness when taken sublingually?
Which atypical antipsychotic has a unique adverse effect of metallic taste and tongue numbness when taken sublingually?
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What is the mechanism of action of Aripiprazole?
What is the mechanism of action of Aripiprazole?
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Which antipsychotic has the highest risk of metabolic syndrome?
Which antipsychotic has the highest risk of metabolic syndrome?
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Which antipsychotic requires dose titration due to orthostatic hypotension?
Which antipsychotic requires dose titration due to orthostatic hypotension?
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Which antipsychotic is contraindicated in patients with hypersensitivity to risperidone?
Which antipsychotic is contraindicated in patients with hypersensitivity to risperidone?
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Which antipsychotic does NOT includes an ODT option?
Which antipsychotic does NOT includes an ODT option?
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Which antipsychotic has a BBW (Black Box Warning) for severe neutropenia?
Which antipsychotic has a BBW (Black Box Warning) for severe neutropenia?
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Which antipsychotic is known for requiring a 350 kcal meal for optimal bioavailability?
Which antipsychotic is known for requiring a 350 kcal meal for optimal bioavailability?
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Which antipsychotic formulation includes an oral tablet, ODT, and suspension options?
Which antipsychotic formulation includes an oral tablet, ODT, and suspension options?
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