BDS10034 Viral Infections: Orofacial Manifestations of HIV Disease

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Which virus is believed to have originated in chimpanzees and then spread to humans, leading to the HIV 1 infection?

Virus X: Chimpanzee subspecies Pan troglodytes troglodytes to apes to man

When were the oral aspects of HIV disease first described?

1980s

How many years passed between the identification of HIV as the cause of AIDS and the revelation of a heterosexual AIDS epidemic in Africa?

15 years

When was the first therapy for AIDS, zidovudine (AZT), approved for use in the USA?

<p>1985</p> Signup and view all the answers

What event marked the launch of Highly Active Antiretroviral Treatment?

<p>The Human Immune Deficiency Virus (HIV) identified as the cause of AIDS</p> Signup and view all the answers

When was the first treatment regimen developed to reduce mother-to-child transmission of HIV?

<p>1995</p> Signup and view all the answers

Which country became the first developing country to provide antiretroviral therapy through its public health system?

<p>Brazil</p> Signup and view all the answers

What event led to the spread of HIV within Africa and across the globe starting in the 1960s?

<p>Effects of European colonialism and urbanization</p> Signup and view all the answers

Which organization launched the '3 x 5' initiative with the goal of reaching 3 million people in the developing world with antiretroviral therapy by 2005?

<p>World Health Organization (WHO)</p> Signup and view all the answers

In which year did the first major downturns in the HIV epidemic in developing countries occur?

<p>1993</p> Signup and view all the answers

Which therapeutic strategy for HIV disease involves the specific inhibition of HIV replication and is generally not available in the developing world?

<p>EIs</p> Signup and view all the answers

What percentage fall in HIV-related deaths occurred between 2005 and 2016?

<p>48%</p> Signup and view all the answers

Which classification system for HIV oral manifestations is outdated but provides a marker of what oral disease can arise if therapy is not given or patients are unaware of their HIV infection?

<p>Malignancy (typically viral-related)</p> Signup and view all the answers

Which type of fungal infection is more common in the developing world and usually correlates with CD4+ T cell count & high viral load?

<p>Superficial candidosis</p> Signup and view all the answers

Which viral infection is more likely in children, not common in adults, and not a strong marker of HIV disease?

<p>HSV-1</p> Signup and view all the answers

'Shingles' is associated with which virus and is not a strong marker of HIV?

<p>Varicella zoster virus</p> Signup and view all the answers

Which virus causes oral hairy leukoplakia and has a low frequency with antiretroviral therapy & reversed by antiretroviral therapy?

<p>Epstein bar virus (EBV)</p> Signup and view all the answers

Which type of HPV oral carriage increases in HIV disease and has a higher prevalence compared to non-HIV individuals?

<p>HPV sub-clinical oral carriage</p> Signup and view all the answers

Which type of HPV has no link with oral sex and reflects activation of previous Epstein bar virus infections?

<p>Low-risk HPV infection</p> Signup and view all the answers

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