JAN 2023 P2

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Questions and Answers

A patient's connective tissue disease is linked to defects in protein glycosylation. Which cellular structure is most likely implicated in this disease?

  • Centriole
  • Ribosome
  • Golgi apparatus (correct)
  • Lysosome
  • Mitochondria

Which of the following exemplifies a fundamental function of the nervous system?

  • Learning Spanish as a second language
  • Voluntary muscle movements (correct)
  • Sweating during a yoga class
  • Thought and speech
  • Doing math calculus

In the phosphorus cycle, which reservoir typically features the lowest concentration of phosphorus?

  • Ocean water
  • Living organisms
  • Rocks and deep ocean sediments
  • Fertilizers and detergents
  • The atmosphere (correct)

In a patient presenting with steatorrhea, which organ is least likely to be the cause?

<p>Stomach (A)</p> Signup and view all the answers

Which statement accurately describes the function of enzymes?

<p>They increase the rate of reaction by stabilizing the transition state. (A)</p> Signup and view all the answers

Based on the provided figure, which stage of mitosis is the cell undergoing?

<p>Early prophase (D)</p> Signup and view all the answers

Which statement explains the time scale involved in the water cycle?

<p>Most of the water on Earth is held in deep water bodies not easily affected by solar energy. (C)</p> Signup and view all the answers

Referring to the provided pedigree for Marfan syndrome, what is the mode of inheritance?

<p>Autosomal -dominant (D)</p> Signup and view all the answers

Considering the Marfan syndrome pedigree, what is the likelihood that 'person A' will have an affected child if they mate with a wild-type individual?

<p>50% (D)</p> Signup and view all the answers

A frog population develops a brown skin mutation that becomes prevalent over generations. Which factor most likely explains this?

<p>Frogs with the brown skin mutation are able to survive and reproduce more successfully than frogs without it. (A)</p> Signup and view all the answers

Disaccharides X and Y yield four monosaccharide molecules with aldehyde functionality upon cleavage. What are X and Y?

<p>X: maltose and Y: maltose (E)</p> Signup and view all the answers

Which vessels transport deoxygenated blood away from the heart?

<p>Pulmonary arteries only (A)</p> Signup and view all the answers

Identify the events that occur during prophase of mitosis:

<p>II only (E)</p> Signup and view all the answers

What process led to French bulldogs having flat faces and shortened snouts?

<p>Artificial selection (A)</p> Signup and view all the answers

What primary physical property of lipoproteins determines their varied biological functions?

<p>density (D)</p> Signup and view all the answers

Which of the following is NOT directly regulated by the renal system?

<p>Blood temperature (C)</p> Signup and view all the answers

Which component is least likely found in the glomerular filtrate of a healthy adult nephron?

<p>Large molecular weight protein (D)</p> Signup and view all the answers

Based on the provided cladogram, what derived trait is shared by kangaroos and foxes but not by platypuses?

<p>Viviparity (C)</p> Signup and view all the answers

On the provided cladogram, which animal shares the most recent common ancestor with the fox?

<p>Monkey (B)</p> Signup and view all the answers

According to the induced fit model of enzyme catalysis, what statement is accurate?

<p>The active site can be influenced by molecules binding elsewhere on an enzyme. (C)</p> Signup and view all the answers

Given the template DNA strand 3' TAC ATG CCC TTC AGA ACT 5', and using the genetic code, what is the resulting amino acid sequence after translation?

<p>Met - Tyr - Gly - Lys - Ser (C)</p> Signup and view all the answers

During which phase of meiosis does crossing over occur?

<p>Prophase I (E)</p> Signup and view all the answers

What level of protein structural organization does the alpha helix represent?

<p>Secondary structure (D)</p> Signup and view all the answers

A DNA molecule contains 20% adenine and 30% guanine. If the molecule has 20 total nucleotides, how many thymine bases are present?

<p>2 (C)</p> Signup and view all the answers

Growth factors and histamine act locally on nearby cells. What type of signaling does this exemplify?

<p>Paracrine function (A)</p> Signup and view all the answers

For an enzyme-catalyzed reaction, which condition does NOT directly affect the reaction rate?

<p>A and C (B)</p> Signup and view all the answers

After consuming a cheeseburger with a milkshake, which hormone would NOT be expected to increase in concentration?

<p>TSH (C)</p> Signup and view all the answers

In the ABO blood group system, if a type-B individual has children with a type-AB individual, what possible blood types can their children have?

<p>Type-AB, type-A, and type-B (B)</p> Signup and view all the answers

Wolman disease results in lipid accumulation due to lysosomal dysfunction. Why do lipids accumulate in this disease?

<p>Normal lysosomes contain different degradative enzymes that can hydrolyze lipids and prevent their accumulation. (D)</p> Signup and view all the answers

Colorblindness, an X-linked recessive trait, affects 5% of males. What is the probability that two children will be both male and colorblind?

<p>6.25% (D)</p> Signup and view all the answers

What part of the kidney is most directly affected by ADH (vasopressin)?

<p>Collecting ducts (B)</p> Signup and view all the answers

High temperatures damage chloroplast membranes. Which consequence is most likely to occur immediately as a result of this?

<p>The chloroplast cannot ensure photosynthesis. (A)</p> Signup and view all the answers

A patient exhibits fatigue, weight gain, hair loss, muscle cramps, and depression. If the doctor suspects a thyroid issue, what blood test results are expected?

<p>The levels of T3 and T4 hormones are low, which indicates hypothyroidism. (C)</p> Signup and view all the answers

Which of the following lists muscle components in order from largest to smallest?

<p>Fascicle, muscle fiber, myofibril (D)</p> Signup and view all the answers

Down syndrome, caused by trisomy 21, occurs due to what type of chromosomal abnormality?

<p>Nondisjunction (C)</p> Signup and view all the answers

Which statement accurately describes the cornea?

<p>Most of the refraction of the incoming light rays occurs at the cornea. (E)</p> Signup and view all the answers

A man with X-linked recessive myopia marries a woman without the allele. What can be said of their offspring?

<p>All their sons will be normal, and all their daughters will be carriers. (C)</p> Signup and view all the answers

During glycolysis, G-6-P binds to hexokinase and blocks ATP access to the site. This phenomenon is...

<p>Competitive inhibition (E)</p> Signup and view all the answers

Why do mammals and birds need separate chambers in their heart?

<p>To prevent the mixing of oxygenated and deoxygenated blood inside the heart (C)</p> Signup and view all the answers

Two polymers, glycogen and amylopectin, each contain 100 monosaccharide subunits, and are cleaved. How many glucose molecules are obtained?

<p>200 (E)</p> Signup and view all the answers

Flashcards

Source of Glycosylation Defects?

The Golgi apparatus is responsible for glycosylation.

Basic Nervous System Functions

These are unconscious, automatic functions.

Phosphorus Cycle Location with Least Phosphorus

The atmosphere has very little phosphorus.

Organ Least Likely to Cause Steatorrhea

Stomach is the least likely cause of steatorrhea.

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Enzymes and Activation Energy

Enzymes lower activation energy by stabilizing the transition state.

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Cell Division Stage

The cell shown is in metaphase.

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Why the Water Cycle Takes Time

Water transfer takes time as most water is deep.

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Marfan Syndrome Transmission

The disease is transmitted as autosomal dominant.

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Probability of Affected Child

The probability is 50%.

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Most Likely Cause of Brown Skin Mutation

Frogs are able to survive and reproduce more successfully with the mutation.

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Disaccharide Identities

X: sucrose and Y: maltose

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Vessels Carrying Deoxygenated Blood

Pulmonary arteries only

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What Occurs During Prophase?

During prophase of mitosis centrioles change into asters.

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French Bulldog Traits Origin

Artificial selection

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Determining Lipoprotein Function

Density of lipoproteins determines their function.

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Renal System's Non-Direct Role

Blood temperature

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Least Likely in Glomerular Filtrate

Large molecular weight protein.

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Traits Shared by Kangaroos and Foxes

Lactation

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Animal Closest to Fox

Monkey

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The Induced Fit Model

The induced fit must occur prior to the initial binding of enzyme and substrate in order for the reaction to proceed.

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Amino Acid Sequence

Sequence: Met - Tyr - Gly - Phe - Ser - Stop

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Crossing Over in Meiosis

Crossing over occurs during prophase I

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Alpha Helix Protein Struct

Alpha helix is a secondary structure

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Thymine Bases in DNA

The number of thymine nitrogenous bases is 2.

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Growth Factor Function

Paracrine function

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Enzyme Reaction

Presence of the enzyme.

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Hormone Levels After Meal

TSH should not be expected to increase.

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Blood Types of Kids

Children could be type-AB, type-A, and type-B.

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Lipids Accumulate Due to...

Normal lysosomes contain different degradative enzymes that can hydrolyze lipids and prevent their accumulation.

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Chance of Colorblind Sons

The probability is 6.25%.

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ADH Affects What?

ADH most directly affects the collecting ducts

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High Temps on Chloroplast...?

ATP production in the cell will decrease.

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The Expected Blood Test Results

The levels of T3 and T4 hormones are low, which indicates hypothyroidism.

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Muscle Structure?

Fascicle, muscle fiber, myofibril.

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Down Syndrome Result Of

Nondisjunction is the abnormality.

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The Cornea Facts

Most of the refraction of the incoming light rays occurs at the cornea.

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Degenerative Myopia!

All their sons will be normal, and all their daughters will be carriers.

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Glycolysis Inhibition

Competitive inhibition is the case.

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Mammalian Heart Reason?

To prevent the mixing of oxygenated and deoxygenated blood inside the heart

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Glycogen Cleaved?

200 molecules of glucose

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Study Notes

Question 41

  • The answer is D. Golgi apparatus
  • Glycosylation is the process of adding carbohydrates to proteins or lipids
  • The Golgi apparatus is responsible for processing and packaging proteins, including glycosylation
  • Abnormal glycosylation patterns suggest a defect in the Golgi apparatus

Question 42

  • The answer is B. Sweating during a yoga class
  • Basic nervous system functions are involuntary and essential for survival.
  • Sweating is a reflex controlled by the autonomic nervous system.
  • Thought, speech, learning, voluntary muscle movements, and doing math calculus require higher-level cognitive processing.

Question 43

  • The answer is A. The atmosphere
  • Phosphorus cycle describes movement of phosphorus through the spheres of earth.
  • Phosphorus is least abundant in atmosphere of all the other spheres.
  • Phosphorus is mostly found in rocks and ocean sediments.

Question 44

  • The answer is A. Stomach
  • Steatorrhea is the presence of excess fat in feces, indicating fat malabsorption.
  • The liver, small intestine, pancreas, and glands of the small intestine walls are all involved in fat digestion and absorption.
  • The stomach primarily handles initial digestion and does not play a major role in fat absorption.

Question 45

  • The answer is C. I and III
  • Enzymes increase reaction rates by stabilizing the transition state
  • Enzymes lower activation energy by altering the reaction pathway.
  • Enzymes do not raise activation energy or shift the equilibrium; they only speed up the rate at which equilibrium is reached.

Question 46

  • The answer is C. Metaphase
  • Chromosomes are aligned at the metaphase plate (middle of the cell).
  • This is a characteristic feature of metaphase in mitosis.

Question 47

  • The answer is A. Most of the water on Earth is held in deep water bodies not easily affected by solar energy.
  • The presence of water in nature is ensured by the water cycle.
  • The water cycle takes time because a large portion of Earth's water is in deep water bodies, which are not easily affected by solar energy.

Question 48

  • The answer is B. Autosomal-dominant
  • The disease appears in every generation.
  • Affected individuals have at least one affected parent.
  • Males and females are equally affected.

Question 49

  • The answer is E. 0%
  • Person A is affected and has an autosomal dominant condition.
  • The condition requires only one copy of the affected allele.
  • The wild-type male does not have any affected allele.
  • The offspring will inherit one allele from each parent.
  • The offspring will have a 0% chance of inheriting the disease.

Question 50

  • The answer is B. Frogs with the brown skin mutation are able to survive and reproduce more successfully than frogs without it.
  • The key factor is the ability to survive and reproduce more successfully.
  • This is the definition of natural selection.

Question 51

  • The answer is B. X: maltose and Y: sucrose
  • Maltose is a disaccharide composed of two glucose molecules, while sucrose is composed of glucose and fructose.
  • Following cleavage, both would yield monosaccharides with aldehyde functionality.

Question 52

  • The answer is B. Pulmonary arteries only
  • Pulmonary arteries carry deoxygenated blood from the heart to the lungs to get oxygenated.
  • Coronary arteries carry oxygenated blood to the heart muscle.
  • Pulmonary veins carry oxygenated blood from the lungs back to the heart.
  • Capillaries are involved in nutrient and waste exchange but do not carry blood away from the heart.

Question 53

  • The answer is E. II and IV
  • During prophase of mitosis, the nuclear membrane disappears, and the centrioles move to opposite poles, forming asters and spindle fibres.
  • Chromosomes line up at the middle of the cell during metaphase.
  • Cytoplasm divides during cytokinesis.

Question 54

  • The answer is B. Artificial selection
  • Artificial selection involves humans intentionally selecting for specific traits in organisms.
  • Selective breeding for short snouts and flat faces caused the traits to appear.

Question 55

  • The answer is D. Density
  • Lipoproteins differ in density due to varying ratios of lipids and proteins.
  • Density influences how they transport lipids in the bloodstream.

Question 56

  • The answer is C. Blood temperature
  • The renal system regulates blood pressure, solute concentrations, pH, and filtration.

Question 57

  • The answer is D. Large molecular weight protein
  • Glomerular filtrate contains water, electrolytes, amino acids, and glucose.
  • Large proteins are typically retained in the blood due to their size.

Question 58

  • The answer is B. Viviparity
  • Viviparity (live birth) is shared by kangaroos and foxes.
  • Platypuses lay eggs (not viviparous).
  • Kangaroos have a pouch, but this isn't necessarily shared by foxes. Lactation is common to all mammals.
  • Two post-orbital fenestrae is not in kangaroos.

Question 59

  • The answer is A. Monkey
  • The cladogram shows shared ancenstry.
  • Monkey is closer to fox than the other species.

Question 60

  • The answer is E. The active site can be influenced by molecules binding elsewhere on an enzyme.
  • Regarding the induced fit model of enzyme catalysis, an enzyme changes shape upon substrate binding.
  • This conformational change optimizes the interaction and can be influenced by molecules binding at sites other than the active site.

Question 61

  • The answer is C. Met - Tyr - Gly - Phe - Ser - Stop
  • Converting template DNA to mRNA sequence yields 5'-AUG CCG AAG UCU UGA-3'
  • AUG is the start codon and codes for methionine.
  • CCG codes for glycine, AAG codes for lysine, and UCU codes for serine. UGA is a stop codon.

Question 62

  • The answer is D. Prophase I
  • Crossing over occurs during prophase I of meiosis.
  • Homologous chromosomes pair up, exchange genetic material, leading to genetic variation.

Question 63

  • The answer is C. Secondary structure
  • The alpha helix is a common secondary structure in proteins.
  • It is formed by hydrogen bonds between amino acids in polypeptide chain.

Question 64

  • The answer is A. 2
  • In DNA, A pairs with T, and G pairs with C.
  • If A is 20% and G is 30%, then T is also 20%, and C is also 30%.
  • Given 20 total nucleotides, T = 20% of 10 = 4.
  • But in reality A=T, so the math done earlier (T = 20% of 10 = 4) is wrong.
  • Given 20 total nucleotides, the number of As= 20% of 20= 4, hence the number of Ts = 4 as well.
  • Given 20 total nucleotides, the number of Gs= 30% of 20= 6, hence the number of Cs = 6 as well.
  • Since %A + %T + %G + %C = 100%, this means %A + %T = 40%, therfore %G + %C = 60%
  • The percentage does not add up to 100%, (20 + 30 + x +y = 100), assuming the number of G is correct.
  • There has to be an error in the amount of Gs in the molecule therefore.
  • Lets assume A=20%, and T=20%, therefore Gs = 30% and Cs = 30%, so this means 20+20+30+x = 100, so x =30%
  • Now we can assume the number of T molecules is 20% of 20= 4, A=4, G =6, and C=6, giving us a total of 20 nucleic acids.

Question 65

  • The answer is B. Paracrine function
  • Paracrine signaling involves a cell releasing a signal that affects nearby cells.

Question 66

  • The answer is D. Presence of the enzyme
  • Factors that affect reaction rate include temperature, pH, substrate concentration.
  • An enzyme acts as only a catalyst
  • Removing the enzyme would stop the forward and backward reaction from occuring.

Question 67

  • The answer is D. Glucagon
  • After consuming a cheeseburger and milkshake, insulin, secretin, and cholecystokinin would be expected to increase
  • Insulin increases due to increase in blood sugar level.
  • Secretin and cholecystokinin increase in response to fat and protein digestion.
  • Glucagon works to raise blood sugar levels and would not be expected to increase.

Question 68

  • The answer is C. Type-AB, type-A, and type-B
  • A person with type-B blood has either BB or BO alleles.
  • A person with type-AB blood has AB alleles.
  • Possible combinations: AB + BB -> AB or BB & AB + BO -> AA, BB, AB, BO.
  • The possible blood types of their children are type-A, type-B, and type-AB.

Question 69

  • The answer is A. Normal lysosomes contain different degradative enzymes that can hydrolyze lipids and prevent their accumulation.
  • Wolman disease is characterized by a lysosomal enzyme deficiency, leading to the accumulation of lipids.

Question 70

  • The answer is D. 6.25%
  • Mother is a carrier so the genotype is XcX.
  • Father is unaffected so the genotype is XY.
  • The possibilities for children are: XX, XcX, XY, XcY.
  • Male and colorblind genotype occurs 1/4 of the time.
  • Thus the probability of the first child being affected and male is 1/4 * 1/2 =1/8. The probability of the second child being affected and male is 1/4 * 1/2 = 1/8.
  • The probability of both children being colorblind and male is (1/4 * 1/2) * (1/4 * 1/2) = 1/64 = 0.015625= 1.5625%

Question 71

  • The answer is A. Collecting ducts
  • ADH (antidiuretic hormone) increases water reabsorption in the collecting ducts of the kidneys.

Question 72

  • The answer is C. ATP production in the cell will decrease.
  • Damage to the chloroplast membrane would affect all functions carried out in the mitochondria.
  • Damage to the membrane affects ATP production.

Question 73

  • The answer is B. The levels of T3 and T4 hormones are low, which indicates hypothyroidism.
  • Hypothyroidism occurs when low T3 and low T4 levels are preesent.
  • Sympoms include fatigue, weight gain, hair loss, muscle cramps, and depression.

Question 74

  • The answer is E. Fascicle, muscle fiber, myofibril
  • A muscle is composed of fascicles.
  • Fascicles are composed of muscle fibers.
  • Muscle fibers are composed of myofibrils.

Question 75

  • The answer is D. Nondisjunction
  • Nondisjunction is the failure of chromosomes to separate properly during cell division.
  • Abnormality such as Trisomy 21 (Downs syndrome) is often a result of nondisjunction.

Question 76

  • The answer is B. Most of the refraction of the incoming light rays occurs at the cornea.
  • The cornea is responsible for most of the refraction (bending) of light as it enters the eye.

Question 77

  • The answer is C. All their sons will be normal, and all their daughters will be carriers.
  • Since the mom has normal vision and does not carry the allele for degenerative myopia, the mom has XX genotype,
  • Since the man has an X-linked disease, his genotype is X'Y.
  • All sons will receive an X chromosome from mom, with genotype X'Y = normal.
  • All daughters will have carriers, with geotype XX'.

Question 78

  • The answer is C. Feedback inhibition
  • Feedback inhibition occurs when the product of a reaction binds to the enzyme.
  • ATP produces G-6-P which blocks the acess to ATP.

Question 79

  • The answer is D. To prevent the mixing of oxygenated and deoxygenated blood inside the heart
  • Mammals and birds have separate chamber to ensure that oxygenated and deoxygenated blood does not mix.

Question 80

  • The answer is E. 200
  • Starch, each containing 100 monosaccharide subunits, are cleaved completely by specific enzymes.
  • 2 polymers containing 100 subunits each will produce 200 molecules of glucose after a complete cleavage.

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