Basal Ganglia and Neurotransmission Quiz
18 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following is a key neurotransmitter system implicated in the pathophysiology of schizophrenia?

  • Serotonergic system
  • Noradrenergic system
  • Cholinergic system
  • Dopaminergic system (correct)
  • What type of receptor is primarily responsible for the rapid, excitatory effects of the neurotransmitter glutamate in the central nervous system?

  • Kainate receptor
  • NMDA receptor
  • Metabotropic glutamate receptor
  • AMPA receptor (correct)
  • Which of the following is considered a leading genetic risk factor for the development of schizophrenia?

  • Overexpression of the APOE gene
  • Polymorphism in the DRD2 gene
  • Deletion in the 22q11.2 chromosomal region (correct)
  • Mutation in the BRCA1 gene
  • Which of the following neurotransmitter receptors is considered a potential therapeutic target for the treatment of cognitive deficits in schizophrenia?

    <p>NMDA receptor</p> Signup and view all the answers

    Which of the following is a proposed mechanism by which environmental factors, such as maternal infection during pregnancy, may increase the risk of developing schizophrenia?

    <p>Activation of the immune system and neuroinflammation</p> Signup and view all the answers

    Which of the following is a key mechanism by which antipsychotic medications exert their therapeutic effects in the treatment of schizophrenia?

    <p>Blockade of dopamine D2 receptors</p> Signup and view all the answers

    Which gene is involved in modulating hippocampal synaptic plasticity and behavior in schizophrenia?

    <p>GATAD2A</p> Signup and view all the answers

    Which gene is responsible for breakdown of extracellular matrix in normal physiological processes related to schizophrenia?

    <p>GATAD2A</p> Signup and view all the answers

    Which gene is associated with neuron development and synapse formation in the context of schizophrenia?

    <p>MMP16</p> Signup and view all the answers

    Which gene enables protein-macromolecule adaptor activity and is involved in negative regulation of transcription in schizophrenia?

    <p>TCF-4</p> Signup and view all the answers

    What function do proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner in schizophrenia?

    <p>MMP16</p> Signup and view all the answers

    Which gene is involved in the initiation of neuronal differentiation related to schizophrenia?

    <p>PSMA4</p> Signup and view all the answers

    What is the main excitatory neurotransmitter in the CNS?

    <p>Glutamate</p> Signup and view all the answers

    Which neurotransmitter is associated with the reward system through CB1R activation?

    <p>Endocannabinoids</p> Signup and view all the answers

    In schizophrenia, what pathway is associated with positive symptoms like hallucinations and delusions?

    <p>Mesolimbic pathway</p> Signup and view all the answers

    Which of the following is NOT a symptom associated with schizophrenia psychopathology?

    <p>Memory loss</p> Signup and view all the answers

    What is the possible cause of schizophrenia related to neurotransmitters?

    <p>Shortage of dopamine in the mesolimbic pathway</p> Signup and view all the answers

    Which ionotropic receptor type is implicated in schizophrenia, particularly in relation to dopamine imbalance?

    <p>Dopamine receptors</p> Signup and view all the answers

    More Like This

    Basal Ganglia Pathways
    30 questions

    Basal Ganglia Pathways

    LawfulNovaculite avatar
    LawfulNovaculite
    Basal Ganglia Function: Indirect Pathway
    30 questions
    Use Quizgecko on...
    Browser
    Browser