18 Questions
Which of the following is a key neurotransmitter system implicated in the pathophysiology of schizophrenia?
Dopaminergic system
What type of receptor is primarily responsible for the rapid, excitatory effects of the neurotransmitter glutamate in the central nervous system?
AMPA receptor
Which of the following is considered a leading genetic risk factor for the development of schizophrenia?
Deletion in the 22q11.2 chromosomal region
Which of the following neurotransmitter receptors is considered a potential therapeutic target for the treatment of cognitive deficits in schizophrenia?
NMDA receptor
Which of the following is a proposed mechanism by which environmental factors, such as maternal infection during pregnancy, may increase the risk of developing schizophrenia?
Activation of the immune system and neuroinflammation
Which of the following is a key mechanism by which antipsychotic medications exert their therapeutic effects in the treatment of schizophrenia?
Blockade of dopamine D2 receptors
Which gene is involved in modulating hippocampal synaptic plasticity and behavior in schizophrenia?
GATAD2A
Which gene is responsible for breakdown of extracellular matrix in normal physiological processes related to schizophrenia?
GATAD2A
Which gene is associated with neuron development and synapse formation in the context of schizophrenia?
MMP16
Which gene enables protein-macromolecule adaptor activity and is involved in negative regulation of transcription in schizophrenia?
TCF-4
What function do proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner in schizophrenia?
MMP16
Which gene is involved in the initiation of neuronal differentiation related to schizophrenia?
PSMA4
What is the main excitatory neurotransmitter in the CNS?
Glutamate
Which neurotransmitter is associated with the reward system through CB1R activation?
Endocannabinoids
In schizophrenia, what pathway is associated with positive symptoms like hallucinations and delusions?
Mesolimbic pathway
Which of the following is NOT a symptom associated with schizophrenia psychopathology?
Memory loss
What is the possible cause of schizophrenia related to neurotransmitters?
Shortage of dopamine in the mesolimbic pathway
Which ionotropic receptor type is implicated in schizophrenia, particularly in relation to dopamine imbalance?
Dopamine receptors
Test your knowledge on the functions of basal ganglia and neurotransmission processes. Learn about how damage to basal ganglia cells can impact speech, movement, and posture, as well as the role of neurotransmitters in fast action and longer activity at the chemical synapse.
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