Bacterial Infections of the CVS 2

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Questions and Answers

What is the typical range for the mean duration of bacterial carriage in salmonella infections?

  • 3-4 weeks
  • 6-8 weeks
  • 4-5 weeks (correct)
  • 1-2 weeks

Which symptom is typically NOT associated with the initial stages of salmonella infections?

  • Constipation (correct)
  • Fever
  • Diarrhea
  • Nausea

In which scenario is bacteremia more likely to occur in salmonella infections?

  • In healthy adults
  • In immunocompromised patients (correct)
  • In children under 5 years old
  • In pregnant women

What are stool cultures able to show following recovery from a salmonella infection?

<p>They may remain positive for several weeks (A)</p> Signup and view all the answers

What is the common pattern of fever observed in patients suffering from salmonella infections?

<p>Gradual onset followed by a high plateau (B)</p> Signup and view all the answers

What is the typical incubation period for Salmonella infections?

<p>10-14 days (C)</p> Signup and view all the answers

Which of the following symptoms is NOT typically associated with enteric fever caused by Salmonella?

<p>Nausea (C)</p> Signup and view all the answers

Which organism is primarily responsible for the majority of clinical diseases caused by Salmonella?

<p>Salmonella enterica subspecies 1 (D)</p> Signup and view all the answers

Which of the following is a characteristic of typhoidal Salmonella infections?

<p>Presence of bradycardia (A)</p> Signup and view all the answers

What classification do most Salmonella infections fall under?

<p>Non-typhoidal Salmonella (B)</p> Signup and view all the answers

Flashcards

Incubation period of Marijuana

The time between exposure to marijuana and the appearance of symptoms, typically 10-14 days.

Symptoms of Marijuana Use

Fever (39.0°C to 40°C), malaise, headache, constipation, bradycardia, myalgia, spleen & liver enlargement, and rose spots.

Salmonella Species

Salmonella is divided into two species (S. enterica) and classified as "typhoidal" and "non-typhoidal" based on strains.

Salmonella enterica subspecies 1

The majority of Salmonella clinical diseases are caused by these strains.

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Rose Spots

Small, blanching pink spots (1-4 mm) often appearing on the chest and abdomen during enteric fever.

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Salmonella Bacteremia

A rare complication of Salmonella infection, usually affecting immunocompromised patients.

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Fever pattern in Salmonella

Initially gradual, then rapidly rises with high plateau; often spiking.

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Typical Salmonella fever

Usually low "typhoidal" type of temperature, but can be varying.

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Stool Culture in Salmonella

Stool cultures are often positive, possibly for weeks after symptoms fade.

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Blood Culture in Salmonella

Blood cultures are often negative, except in more severe cases.

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Duration of Salmonella Carriage

The time a person carries the bacteria after recovery; typically 4-5 weeks.

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Early Salmonella Symptoms

Constipation initially, then nausea, vomiting, and later, bloody diarrhea.

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Best time for stool culture

Taking a stool sample during the early stages of the disease yields better results.

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Study Notes

Bacterial Infections of the CVS and Lymphatics 2

  • Enterobacteriaceae are a large group of gram-negative rods found in the intestinal tracts of humans and animals.
    • Characteristics: Faculative anaerobes, ferment glucose, reduce nitrate, and are oxidase-negative.
    • Lactose fermentation:
      • Rapid: Escherichia coli, Enterobacter, Klebsiella.
      • Slow: Serratia, some Shigella sonnei (extended incubation), Salmonella Arizona subgroup.
      • Not fermented: Proteus, Salmonella, Shigella.
  • Antigenic Structures:
    • O Antigens: >150, heat-stable, found on the cell wall.
    • K Antigens (Capsular Antigens): >100, heat-labile, interfere with O antigen agglutination.
    • H Antigens (Flagellar Antigens): >50, located on flagella, denatured by heat/alcohol.
  • Escherichia coli (E. coli):
    • Clinical Diseases: Urinary tract infections, diarrheal diseases (EPEC, ETEC, STEC, EIEC, EAEC), meningitis, sepsis.
    • Laboratory Tests: Gram staining, MacConkey/EMB Agar, Triple Sugar Iron (TSI) Test, IMVIC Test.
  • Salmonella spp.:
    • Characteristics: Gram-negative rods, non-sporeformers.
    • Classifications: Typhoidal (e.g., Typhi, Paratyphi) and non-typhoidal.
    • Clinical Diseases: Enteric fever (typhoid fever), enterocolitis, septicemia.
    • Laboratory Diagnosis: Differential Medium Cultures, enrichment culturing, selective medium cultures, serological methods.
  • Proteus spp.:
    • Characteristics: Gram-negative, highly motile bacilli.
    • Laboratory Diagnosis: Swarming motility, urease production, indole test, TSI reaction.
  • Serratia spp.:
    • Characteristics: Motile, slow lactose fermenters, important opportunistic pathogens.
    • Clinical Diseases: Pneumonia, bacteremia, wound infections, meningitis, and endocarditis (IV drug users).
    • Laboratory Diagnosis: Red pigment (prodigiosin), DNAse, nitrate, citrate, ornithine decarboxylase, Voges-Proskauer, TSI.
  • Prevention: Good hygiene, food safety procedures, vaccine use (where available).

Treatment

  • E. coli: Fluoroquinolones (Ciprofloxacin, Levofloxacin), Azithromycin.
  • Salmonella: Azithromycin, 3rd generation cephalosporin (ceftriaxone), fluoroquinolone.
  • Proteus: Penicillin-related antibiotics, trimethoprim-sulfamethoxazole, cephalosporins, aminoglycosides, imipenem.
  • Serratia spp.: Difficult treatment due to antibiotic resistance. Therapy may depend on exact strain.

Additional Information

  • Bacterial Identification: Different tests distinguish characteristics and species of bacteria.
  • Etiologic Agents: Understanding the specific causative agents of infections.
  • Clinical Diseases: Recognizing specific illnesses and associated risk factors.
  • Management and control measures: Strategies for managing infections.

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