Bacteria Review: Enterobacteriaceae
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Questions and Answers

What term describes the inflammation of the entire digestive tract?

  • Gastroenteritis (correct)
  • Dysentery
  • Enteric fever
  • Enteritis

Which of the following is classified as a primary (frank) pathogen known for causing diarrheal diseases?

  • Klebsiella
  • Enterobacter
  • Salmonella (correct)
  • Proteus

What characterizes dysentery?

  • Severe abdominal pain without any stool production
  • Persistent fever with no gastrointestinal symptoms
  • Frequent watery stools followed by mucus and blood (correct)
  • Diarrhea with dehydration but no pain

Which genera is NOT considered an opportunistic pathogen?

<p>Yersinia (C)</p> Signup and view all the answers

What does enteric fever initially present as?

<p>Fever, headache, abdominal pain, and cramping (C)</p> Signup and view all the answers

What is the most common source of salmonellosis in the U.S.?

<p>Contaminated poultry and eggs (A)</p> Signup and view all the answers

What is the incubation period for salmonellosis?

<p>12 to 48 hours (A)</p> Signup and view all the answers

Which of the following symptoms is NOT associated with salmonellosis?

<p>High-grade fever (A)</p> Signup and view all the answers

Which Salmonella species is primarily responsible for salmonellosis in humans?

<p>Salmonella typhimurium (A)</p> Signup and view all the answers

How long do the symptoms of salmonellosis typically last?

<p>2 to 5 days (A)</p> Signup and view all the answers

What is a common characteristic of Enterobacteriaceae?

<p>Motile or non-motile (D)</p> Signup and view all the answers

Which of the following diseases is NOT commonly associated with Enterobacteriaceae?

<p>Tuberculosis (D)</p> Signup and view all the answers

What type of antigens helps in the serological classification of Enterobacteriaceae?

<p>H antigen (A)</p> Signup and view all the answers

Which biochemical test is crucial for the identification of Enterobacteriaceae?

<p>Nitrate reduction (D)</p> Signup and view all the answers

What is the typical environment where Enterobacteriaceae can be found?

<p>In diverse habitats such as soil and water (B)</p> Signup and view all the answers

Which of the following is a characteristic of Enterobacteriaceae's relationship with the intestinal tract?

<p>They are part of the normal flora. (C)</p> Signup and view all the answers

Which characteristic is true of most Enterobacteriaceae regarding glucose?

<p>They ferment glucose and produce acid. (D)</p> Signup and view all the answers

Which classification method utilizes aspects like the ability to colonize, adhere, and produce toxins?

<p>Serological classification (A)</p> Signup and view all the answers

What organism is responsible for causing typhoid fever?

<p>Salmonella typhi (B)</p> Signup and view all the answers

Which of the following symptoms is NOT typically associated with typhoid fever?

<p>Cramps (B)</p> Signup and view all the answers

What is the primary target host cell for Salmonella typhi?

<p>Small intestine cells (D)</p> Signup and view all the answers

How is typhoid fever primarily transmitted?

<p>Ingestion of contaminated food or water (D)</p> Signup and view all the answers

Which bacterium is responsible for causing bubonic and pneumonic plague?

<p>Yersinia pestis (D)</p> Signup and view all the answers

What is a distinguishing feature of Yersinia enterocolitica?

<p>Does not respond to antibiotics (B)</p> Signup and view all the answers

During what incubation period does typhoid fever typically manifest?

<p>1-2 weeks (C)</p> Signup and view all the answers

What symptom indicates that Salmonella typhi bacteria have entered the bloodstream?

<p>Rose spots (C)</p> Signup and view all the answers

What is the primary role of Escherichia coli in the human intestinal tract?

<p>Producing vitamin K (D)</p> Signup and view all the answers

Which strain of E. coli is mainly associated with traveler’s diarrhea?

<p>Enterotoxigenic E. coli (ETEC) (A)</p> Signup and view all the answers

What symptom is NOT associated with Enteropathogenic E. coli (EPEC)?

<p>Bloody diarrhea (C)</p> Signup and view all the answers

What virulence factor contributes to E. coli's ability to adhere to host cells?

<p>Pili (D)</p> Signup and view all the answers

Which strain of E. coli is characterized by the production of verotoxins?

<p>Enterohemorrhagic E. coli (EHEC) (D)</p> Signup and view all the answers

What is the main symptom of dysentery caused by Shigella?

<p>Severe abdominal cramps (A)</p> Signup and view all the answers

What is the infectious dose for Shigella to cause illness?

<p>Less than 200 cells (C)</p> Signup and view all the answers

Which of the following strains causes hemorrhagic colitis and potentially progresses to hemolytic uremic syndrome?

<p>Enterohemorrhagic E. coli (EHEC) (A)</p> Signup and view all the answers

Which feature distinguishes E. coli from Shigella?

<p>E. coli can be part of normal flora in the intestine (B)</p> Signup and view all the answers

What type of infection is primarily caused by Salmonella?

<p>Bacterial gastroenteritis (D)</p> Signup and view all the answers

Which symptom is characteristic of Enteroinvasive E. coli (EIEC)?

<p>Fever (B)</p> Signup and view all the answers

What is a common feature of Enteropathogenic E. coli (EPEC) infection?

<p>Fluid loss leading to dehydration (C)</p> Signup and view all the answers

In which age group is childhood mortality significantly influenced by E. coli infections?

<p>Children from 1 to 5 years (D)</p> Signup and view all the answers

What is the role of pili in E. coli infections?

<p>They facilitate attachment to host cells (D)</p> Signup and view all the answers

What is typically NOT a symptom of Enterotoxigenic E. coli (ETEC)?

<p>Severe abdominal pain (D)</p> Signup and view all the answers

What is the primary vector for Bubonic plague?

<p>Fleas (D)</p> Signup and view all the answers

What condition is commonly caused by Klebsiella pneumoniae in immunocompromised patients?

<p>Pneumonia (A)</p> Signup and view all the answers

Which of the following pathogens is known for producing AB toxins that can lead to severe dehydration?

<p>Vibrio cholerae (D)</p> Signup and view all the answers

Which organism is associated with causing extraintestinal infections, such as UTIs and pneumonia?

<p>Enterobacter cloacae (D)</p> Signup and view all the answers

What is a characteristic of Proteus mirabilis?

<p>Highly motile (B)</p> Signup and view all the answers

What typically causes the symptoms associated with Campylobacter jejuni infections?

<p>Consumption of undercooked meat (C)</p> Signup and view all the answers

What symptom is NOT typically associated with infections caused by Citrobacter species?

<p>Gastric ulcers (D)</p> Signup and view all the answers

Which of the following was discovered as an opportunistic pathogen linked to nosocomial outbreaks?

<p>Klebsiella (D)</p> Signup and view all the answers

How do bacteria within the Vibrio genus primarily exist in the environment?

<p>In aquatic or marine environments (A)</p> Signup and view all the answers

Which pathogen is most closely linked to rice water stool in diarrheal disease?

<p>Vibrio cholerae (D)</p> Signup and view all the answers

What type of infections can Enterobacter species cause?

<p>Extraintestinal infections (A)</p> Signup and view all the answers

Which organism is known for its unique corkscrew motion?

<p>Helicobacter pylori (C)</p> Signup and view all the answers

What is a common consequence of untreated Vibrio cholerae infections?

<p>Severe dehydration (D)</p> Signup and view all the answers

Flashcards

Primary Pathogen

A pathogen that directly causes a disease.

Opportunistic Pathogen

A pathogen that causes disease only in a weakened state or new environment.

Diarrhea

Frequent, watery stools.

Dysentery

Disease with watery stools then scant stools with blood and mucus.

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Enteric Fever

Fever presentation with head/abdominal pain, cramping and bacteremia.

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Enterobacteriaceae bacteria

A family of bacteria often found in the digestive system, associated with intestinal infections. It is also present in various environments like soil, water, and plants.

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Enterobacteriaceae characteristics

Gram-negative rods, catalase-positive, oxidase-negative, (usually) actively motile bacteria fermenting glucose and producing acid end products, and reducing nitrate to nitrite. They are not demanding for nutrients.

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Serological classification

Classifying Enterobacteriaceae based on the bacteria's cell surface features, such as their ability to adhere, colonize, produce toxins, and invade tissues.

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O antigen

A heat-stable somatic antigen used in the serological classification of Enterobacteriaceae.

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H antigen

A heat-labile flagellar antigen used in the serological classification of Enterobacteriaceae.

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K antigen

A heat-labile capsular antigen used in the serological classification of Enterobacteriaceae.

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Biochemical tests

Essential tests used for identify, diagnosing and treating Enterobacteriaceae infections, since they are medically important.

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Enteric Diseases

Diseases caused by Enterobacteriaceae bacteria, like dysentery, typhoid, or food poisoning.

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Salmonellosis Incubation

The time it takes for salmonellosis symptoms to appear after exposure, typically 12 to 48 hours.

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Salmonellosis Symptoms

Includes low-grade fever, abdominal pain, non-bloody diarrhea, and vomiting.

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Salmonellosis Exposure

Frequent exposure often involves contaminated poultry and eggs, requiring a high infectious dose (millions of cells).

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Salmonellosis Target Cells

Salmonella infects the small and large intestines.

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Salmonellosis Duration

Usually self-limiting and resolves within 2-5 days.

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Emesis

Vomiting

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Malnutrition

Poor nutrition due to insufficient calories for normal body function.

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Undernourished

Lacking sufficient calories for normal body function.

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Infant mortality

Death in children up to one year old.

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Childhood mortality

Death in children between 1 and 12 years old.

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Escherichia coli (E. coli)

A bacterium found in the human intestines; both opportunistic and primary pathogen.

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Enteroaggregative E. coli (EAggEC)

Opportunistic type of E. coli that attaches to intestinal cells causing diarrhea.

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Enteropathogenic E. coli (EPEC)

Causes childhood diarrhea by destroying small intestine microvilli.

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Enterotoxigenic E. coli (ETEC)

Causes traveler's diarrhea through toxins that affect the small intestine.

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Enteroinvasive E. coli (EIEC)

Invades intestinal cells, causing dysentery-like symptoms.

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Enterohemorrhagic E. coli (EHEC)

Produces toxins that cause bloody diarrhea and can lead to kidney damage.

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Hemolytic Uremic Syndrome (HUS)

A serious complication of EHEC infection, characterized by anemia, low platelets, and kidney failure.

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Shigella

A bacterium that invades the intestines causing dysentery.

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Salmonella

A bacterium, often from animals, causing food poisoning.

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Salmonella typhi

A bacterium that causes typhoid fever, contracted through contaminated food or water. It invades the small intestine and bloodstream leading to fever, headache, muscle pain, and gastrointestinal distress.

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Typhoid Fever Incubation

The period between exposure to Salmonella typhi and the onset of symptoms, typically lasting 1-2 weeks.

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Rose Spots

A telltale rash that can appear on the chest or abdomen in some typhoid fever patients. It's a sign that the bacteria has entered the bloodstream.

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Yersinia

A genus of bacteria that includes some disease-causing species. It does not typically exist as normal flora in humans.

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Yersinia enterocolitica

A bacterium that causes gastrointestinal illness, characterized by fever, abdominal pain, and diarrhea. It often causes community outbreaks.

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Yersinia pestis

A bacterium that causes plague, spread through rodents and fleas, and can manifest as bubonic or pneumonic plague.

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Bubonic Plague

A form of plague caused by Yersinia pestis, characterized by swollen lymph nodes, fever, and chills.

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Pneumonic Plague

A form of plague caused by Yersinia pestis, affecting the lungs and causing severe respiratory distress.

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Cutaneous Anthrax

A skin infection caused by Bacillus anthracis, characterized by a painless sore that develops into a black, necrotic lesion.

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Citrobacter freundii

A bacterium commonly found as normal intestinal flora, but can cause infections like UTIs, pneumonias, and intra-abdominal abscesses.

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Klebsiella pneumoniae

A bacterium found in the gastrointestinal tract, known for causing nosocomial infections like pneumonia and UTIs in immunocompromised individuals.

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Enterobacter

A genus of bacteria commonly found in the gut, capable of causing UTIs and respiratory tract infections.

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Serratia marcescens

A common nosocomial pathogen known for its antibiotic resistance and causing infections like UTIs, respiratory infections, and bacteremia.

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Proteus mirabilis

A highly motile bacterium associated with UTIs and wound infections, commonly found in individuals with chronic health problems.

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Edwardsiella tarda

A bacterium found in aquatic environments, capable of causing gastroenteritis, wound infections, and bacteremia.

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Providencia alcalifaciens

A bacterium typically found in other animals but can cause diarrheal disease in children, particularly challenging to treat due to antibiotic resistance.

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Vibrio cholerae

A bacterium responsible for cholera, a severe diarrheal disease characterized by rice water stool and dehydration, often linked to contaminated water.

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Campylobacter jejuni

A bacterium found in animal intestines, transmitted through contaminated food, causing diarrheal disease with mild abdominal pain, cramps, and diarrhea.

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Helicobacter pylori

A bacterium found in the stomach, responsible for gastric and duodenal ulcers, often difficult to heal and treated with antibiotics.

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AB Toxins

Toxins produced by Vibrio cholerae with two subunits: A disrupts chloride ion balances, causing dehydration, and B opens channels in cell membranes.

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Cholera Antitoxin

A treatment for cholera that works by neutralizing the exotoxins produced by Vibrio cholerae.

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Study Notes

Bacteria Review

  • Enterobacteriaceae are often referred to as "enterics," found in the digestive system. They are commonly associated with intestinal infections and are part of the normal flora in animal intestinal tracts. They're found in various environments like soil, water, plants, and more.
  • Enterobacteriaceae are significant causative agents of enteric diseases such as dysentery, typhoid, and food poisoning. Biochemical tests are vital for identification, diagnosis, and treatment due to their similar characteristics.
  • Gram-negative rods are a common characteristic of Enterobacteriaceae. They are typically catalase-positive and oxidase-negative, but some might show oxidase positivity in lab settings. Many are motile; some are not. They ferment glucose and produce acid end products and reduce nitrate to nitrite.
  • Two ways of classification:
    • Serological classification focuses on the ability to colonize, adhere, produce toxins, and invade; some possess plasmids. Identification is based on antigens. O antigen is heat stable/somatic. H antigen is flagellar/heat-labile. K antigen is capsular/heat-labile, and often forms capsules.
    • Disease classification categorizes them based on primary and opportunistic pathogens. Primary pathogens often cause a range of diarrheal diseases in animals and humans, frequently impacting children. Opportunistic pathogens typically do not cause disease in their natural habitat but may pose a threat in new environments; causing extraintestinal infections.
  • Escherichia coli (E. coli):
    • A major species in Escherichia. It is an opportunistic and primary pathogen; frequently found in the normal flora of the human intestinal tract. It produces large amounts of vitamin K within the large intestine.
    • Can cause urinary tract infections and kidney infections in humans but can also cause septicemia and meningitis in neonates. It is also associated with various diarrheal diseases depending on the strain. Symptoms include watery diarrhea, vomiting, and dehydration.
  • Enterotoxigenic E. coli (ETEC): A common cause of traveler's diarrhea. The infectious dose ranges from 1 million to 10 billion cells, affecting the small intestine.
  • Enteroinvasive E. coli (EIEC): This E. coli is an opportunistic pathogen that causes dysentery, often resembling the symptoms associated with Shigella. It has an infectious dose ranging from 1 million to 100 million cells.
  • Enterohemorrhagic E. coli (EHEC): This type of E. coli is a known pathogen, and often causes severe diseases like hemorrhagic colitis and hemolytic uremic syndrome (HUS), especially in children, characterized by bloody diarrhea and kidney damage. The infectious dose is between 1 million to 100 million cells.
  • Shigella: A primary, invasive pathogen known for its infection outbreaks associated with diarrhea. Symptoms can include bloody diarrhea and serious complications like infections like hemolytic uremic syndrome (HUS).
  • Salmonella: A frank pathogen that causes infections in humans through a variety of symptoms such as fever, cramps, and diarrhea.
  • Yersinia: This bacterial species is known to cause infections like diarrhea and septicemia in humans, often impacting children.
  • Citrobacter: This bacteria is known as an opportunistic pathogen, causing UTIs and infections in immunocompromised individuals.
  • Enterobacter: Another opportunistic pathogen frequently implicated in infections such as UTIs, wound infections, septicemia and pneumonia if severe.
  • Serratia: This opportunistic pathogen is linked with nosocomial outbreaks and has developed antibiotic resistance in some strains.
  • Providencia: Is common in opportunistic infections, especially those seen in hospital settings and in those with compromised immune systems.
  • Edwardsiella: An opportunistic pathogen often found in aquatic environments, that can cause digestive problems in humans.
  • Vibrio: A gram-negative bacterium usually found in aquatic marine environments. It is frequently found causing issues for those that consume improperly treated water.
  • Campylobacter: A frequent cause of food poisoning from consuming unpasteurized dairy products.
  • Helicobacter: Known for being an opportunistic pathogen causing stomach ulcers.

Additional Notes

  • Terms relating to disease, such as diarrhea; are included such as frequent watery stools.
  • Numerous virulence factors and symptoms associated with various bacterial infections are described.

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Description

This quiz focuses on the Enterobacteriaceae family, their characteristics, and classification. You'll explore their role in intestinal infections, biochemical identification, and the significance of their serological classification. Test your knowledge on these important bacteria and their impact on health.

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