Podcast
Questions and Answers
What do B cells assemble in the bone marrow?
What do B cells assemble in the bone marrow?
- Soluble forms of IgM and IgD with different antigen binding sites
- Cell surface forms of IgM monomer (sIgM) and IgD (sIgD) with the same antigen binding site (correct)
- Cell surface forms of IgM monomer (sIgM) and IgD (sIgD) with different antigen binding sites
- Soluble forms of IgM and IgD with the same antigen binding site
What are the 3 outcomes of B cells in the bone marrow that express sIgM and sIgD and recognize self-antigens?
What are the 3 outcomes of B cells in the bone marrow that express sIgM and sIgD and recognize self-antigens?
- Undergo apoptosis, undergo further DNA rearrangement of surface Ig, or migrate to the spleen and lymph nodes (correct)
- Undergo apoptosis, undergo further DNA rearrangement of surface Ig, or differentiate into effector B cells
- Undergo apoptosis, undergo further DNA rearrangement of surface Ig, or differentiate into plasma cells
- Undergo apoptosis, migrate to the spleen and lymph nodes, or differentiate into memory B cells
What are the first 2 antibodies produced in an antibody response?
What are the first 2 antibodies produced in an antibody response?
- IgG and IgA
- IgD and IgM (correct)
- IgA and IgE
- IgG and IgM
How are B lymphocytes in the spleen or lymph nodes activated?
How are B lymphocytes in the spleen or lymph nodes activated?
What are the 3 outcomes of B cell proliferation?
What are the 3 outcomes of B cell proliferation?
What is class switching in B cells determined by, and what are the 3 responses?
What is class switching in B cells determined by, and what are the 3 responses?
What cytokine can block IgA activation?
What cytokine can block IgA activation?
What occurs simultaneously with class switching, and what enzyme initiates both processes?
What occurs simultaneously with class switching, and what enzyme initiates both processes?
Why is the secondary antibody response stronger than the primary response?
Why is the secondary antibody response stronger than the primary response?
What initiates somatic hypermutation in B cells?
What initiates somatic hypermutation in B cells?
Which antibody class is activated by IL-21 cytokine?
Which antibody class is activated by IL-21 cytokine?
What is the main function of AID in B cells?
What is the main function of AID in B cells?
Which outcome is a result of competition during somatic hypermutation?
Which outcome is a result of competition during somatic hypermutation?
What determines the specificity of IgG1 and IgG3 antibodies produced by B cells?
What determines the specificity of IgG1 and IgG3 antibodies produced by B cells?
What is the main role of class switching in B cells?
What is the main role of class switching in B cells?
Which response activates IgE antibodies in B cells?
Which response activates IgE antibodies in B cells?
What is the outcome of Th cell recognition of MHC II on B cells?
What is the outcome of Th cell recognition of MHC II on B cells?
How does the affinity maturation process affect B cell responses?
How does the affinity maturation process affect B cell responses?
What process introduces point mutations in V region exons during RNA transcription in B cells?
What process introduces point mutations in V region exons during RNA transcription in B cells?
What is the initial cell type that gives rise to B lymphocytes?
What is the initial cell type that gives rise to B lymphocytes?
What is the sequence of maturation stages for a B cell?
What is the sequence of maturation stages for a B cell?
Which region of an antibody is responsible for binding to antigens?
Which region of an antibody is responsible for binding to antigens?
What are the polypeptide components of an antibody?
What are the polypeptide components of an antibody?
Which domains of an antibody form the binding site for antigens?
Which domains of an antibody form the binding site for antigens?
What is the primary function of antibodies?
What is the primary function of antibodies?
Which of the following is NOT a mechanism by which antibodies prevent infection?
Which of the following is NOT a mechanism by which antibodies prevent infection?
What is the alternative name for antibodies?
What is the alternative name for antibodies?
Where do B lymphocytes originate and mature?
Where do B lymphocytes originate and mature?
What is the role of the Fc region of an antibody?
What is the role of the Fc region of an antibody?
What is the function of the flexible hinge region in antibodies?
What is the function of the flexible hinge region in antibodies?
What is the primary function of the heavy chain in antibodies?
What is the primary function of the heavy chain in antibodies?
Which antibody class is primarily responsible for transplacental transport?
Which antibody class is primarily responsible for transplacental transport?
What is the primary function of IgE antibodies?
What is the primary function of IgE antibodies?
What is the primary location and function of IgA antibodies?
What is the primary location and function of IgA antibodies?
What is the primary mechanism that contributes to the diversity of antibodies?
What is the primary mechanism that contributes to the diversity of antibodies?
What is the role of the Complementarity Determining Regions (CDRs) in antibodies?
What is the role of the Complementarity Determining Regions (CDRs) in antibodies?
Which antibody class is primarily involved in signaling B cell activation?
Which antibody class is primarily involved in signaling B cell activation?
What is the primary function of the Fc region in antibodies?
What is the primary function of the Fc region in antibodies?
Which antibody class is primarily involved in the activation of the complement system?
Which antibody class is primarily involved in the activation of the complement system?
