B Cell Proliferation Outcomes Quiz
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Questions and Answers

What is the main function of Th cells in the immune response?

  • Activate B cells to produce antibodies (correct)
  • Induce apoptosis in B cells
  • Recognize MHC I
  • Directly attack pathogens

Which molecule is responsible for the signal from Th cells to B cells during class switching?

  • IL-21
  • CD40
  • IgM
  • CD154 (correct)

In what location are IgA antibodies mainly transported to by B cells upon activation?

  • Bone marrow
  • Mucosal surfaces (correct)
  • Lymph nodes
  • Bloodstream

Which process introduces point mutations in V region exons of B cells during RNA transcription?

<p>Somatic hypermutation (D)</p> Signup and view all the answers

What is the enzyme responsible for converting cytosine to uracil during somatic hypermutation?

<p>Cytidine Deaminase (A)</p> Signup and view all the answers

What is the main outcome of competition among B cells with different antigen receptors?

<p>Diversity in the mutated forms of antigen receptors (A)</p> Signup and view all the answers

Which cytokine can block the activation of IgA antibodies by IL-21 in B cells?

<p>[IL-4] (D)</p> Signup and view all the answers

What is the mechanism by which high affinity plasma and memory cells are selected during somatic hypermutation?

<p>[APOPTOSIS] of low affinity B cells (A)</p> Signup and view all the answers

Which factor contributes more significantly to affinity maturation between class switching and somatic hypermutation?

<p>[Somatic hypermutation] (D)</p> Signup and view all the answers

Why are memory B cells able to produce antibodies with higher affinity during the secondary response?

<p>Due to affinity maturation through somatic hypermutation (A)</p> Signup and view all the answers

Flashcards

Th cell function

Th cells activate B cells to produce antibodies.

CD154 signal

CD154 is the molecule that Th cells use to signal B cells for class switching.

IgA transport location

Activated B cells transport IgA antibodies to mucosal surfaces.

Somatic hypermutation

Process that introduces mutations in B cell's V region exons during RNA transcription.

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Cytidine Deaminase role

Cytidine Deaminase converts cytosine to uracil during somatic hypermutation.

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B cell diversity

Competition among B cells with different antigen receptors leads to diversity in mutated antigen receptors.

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IL-4 and IgA

IL-4 can block the activation of IgA antibodies by IL-21 in B cells.

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High affinity selection

High affinity plasma and memory cells are selected through apoptosis of low-affinity B cells after somatic hypermutation.

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Affinity maturation factor

Somatic hypermutation contributes more significantly to affinity maturation than class switching.

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Memory B cell affinity

Memory B cells produce antibodies with higher affinity during the secondary response due to somatic hypermutation.

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Affinity Maturation

Affinity maturation is the enhancement of antibody affinity. It includes somatic hypermutation.

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Somatic Hypermutation impact

Somatic hypermutation directly changes the antibody protein

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Class Switch impact

Class switching is changes to different types of antibodies.

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B cell activation

B cells must be first activated by a T cell.

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Antibodies

Antibodies are proteins made by B cells that fight infection

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Plasma cells

Plasma cells are cells that produce antibodies

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Memory cells

Memory cells remember past infections.

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