B Cell Development and Activation Quiz

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Which type of B cell is activated by CD4 and reenters the follicle to proliferate in the dark zone?

Plasma cells

Memory cells

Naïve B cells (correct)

Follicular DC (FDC)

What is the function of the germinal center within the lymphoid follicle?

To produce high levels of antibodies

To interact with follicular DC (FDC) and CD4 cells

To stimulate affinity maturation (correct)

To differentiate B cells into plasma cells

Which of the following is true about the 3-Signal Hypothesis?

Specific antigen binds to CD4 TCR (correct)

CD28 binds to CD40L

Costimulation is not required for B cell activation

Cytokines are not involved in proliferation and differentiation

During the B cell response, what happens in the clonal expansion phase?

B cells secrete IgM Signup and view all the answers

Which cytokine is responsible for inducing isotype switching to IgG?

IFN-gamma Signup and view all the answers

Which Fc receptor is responsible for transferring IgG across cells while protecting it from lysosomal degradation?

FcyRIIB Signup and view all the answers

Which antibody is the most effective in complement-mediated lysis?

IgM Signup and view all the answers

Which process is inhibited by the binding of antibodies to pathogens?

Neutralization Signup and view all the answers

Which type of B cell is responsible for the production of IgM during the primary immune response?

Naïve B cells Signup and view all the answers

What is the main difference between the primary and secondary immune responses?

The primary response is slower and of lower magnitude compared to the secondary response Signup and view all the answers

Which of the following is true about B cell development?

B cell development starts in the bone marrow and completes maturation in secondary lymph tissues. Signup and view all the answers

What is the primary sign of B cell maturity?

Expression of surface IgD Signup and view all the answers

Which of the following is true about direct antigen acquisition and activation?

Whole antigens bind directly to BCR without processing. Signup and view all the answers

What happens during indirect antigen acquisition and activation?

Antigens are captured by APCs and transferred to BCR. Signup and view all the answers

Which specialized APCs are involved in capturing antigens and transferring them to B cells?

Dendritic cells Signup and view all the answers

Which type of B cell activation is T-independent?

B cell binds native, conformational antigen. Signup and view all the answers

What is the role of CD4 T cell help in T-dependent B cell activation?

CD4 T cell help is critical for long-term production of antibodies to polysaccharide antigens. Signup and view all the answers

Where does T cell activation and B cell activation occur in the lymph node?

T cell activation occurs in the T cell zone, while B cell activation occurs in the B cell zone. Signup and view all the answers

What happens during T-B cell interactions in the lymph node follicles?

T and B cells produce chemokines and move toward each other. Signup and view all the answers

What is the outcome of T-B cell interactions in the lymph node follicles?

B cells become short-lived plasma cells with low-level antibody production. Signup and view all the answers