20 Questions
Which type of B cell is activated by CD4 and reenters the follicle to proliferate in the dark zone?
Naïve B cells
What is the function of the germinal center within the lymphoid follicle?
To stimulate affinity maturation
Which of the following is true about the 3-Signal Hypothesis?
Specific antigen binds to CD4 TCR
During the B cell response, what happens in the clonal expansion phase?
B cells secrete IgM
Which cytokine is responsible for inducing isotype switching to IgG?
IFN-gamma
Which Fc receptor is responsible for transferring IgG across cells while protecting it from lysosomal degradation?
FcyRIIB
Which antibody is the most effective in complement-mediated lysis?
IgM
Which process is inhibited by the binding of antibodies to pathogens?
Neutralization
Which type of B cell is responsible for the production of IgM during the primary immune response?
Naïve B cells
What is the main difference between the primary and secondary immune responses?
The primary response is slower and of lower magnitude compared to the secondary response
Which of the following is true about B cell development?
B cell development starts in the bone marrow and completes maturation in secondary lymph tissues.
What is the primary sign of B cell maturity?
Expression of surface IgD
Which of the following is true about direct antigen acquisition and activation?
Whole antigens bind directly to BCR without processing.
What happens during indirect antigen acquisition and activation?
Antigens are captured by APCs and transferred to BCR.
Which specialized APCs are involved in capturing antigens and transferring them to B cells?
Dendritic cells
Which type of B cell activation is T-independent?
B cell binds native, conformational antigen.
What is the role of CD4 T cell help in T-dependent B cell activation?
CD4 T cell help is critical for long-term production of antibodies to polysaccharide antigens.
Where does T cell activation and B cell activation occur in the lymph node?
T cell activation occurs in the T cell zone, while B cell activation occurs in the B cell zone.
What happens during T-B cell interactions in the lymph node follicles?
T and B cells produce chemokines and move toward each other.
What is the outcome of T-B cell interactions in the lymph node follicles?
B cells become short-lived plasma cells with low-level antibody production.
Test your knowledge on B cell development, direct antigen acquisition, and activation in this quiz. Recall key steps in B cell maturation, the primary sign of maturity, and the process of antigen binding to B cell receptors.
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