Podcast
Questions and Answers
Which type of B cell is activated by CD4 and reenters the follicle to proliferate in the dark zone?
Which type of B cell is activated by CD4 and reenters the follicle to proliferate in the dark zone?
- Plasma cells
- Memory cells
- Naïve B cells (correct)
- Follicular DC (FDC)
What is the function of the germinal center within the lymphoid follicle?
What is the function of the germinal center within the lymphoid follicle?
- To produce high levels of antibodies
- To interact with follicular DC (FDC) and CD4 cells
- To stimulate affinity maturation (correct)
- To differentiate B cells into plasma cells
Which of the following is true about the 3-Signal Hypothesis?
Which of the following is true about the 3-Signal Hypothesis?
- Specific antigen binds to CD4 TCR (correct)
- CD28 binds to CD40L
- Costimulation is not required for B cell activation
- Cytokines are not involved in proliferation and differentiation
During the B cell response, what happens in the clonal expansion phase?
During the B cell response, what happens in the clonal expansion phase?
Which cytokine is responsible for inducing isotype switching to IgG?
Which cytokine is responsible for inducing isotype switching to IgG?
Which Fc receptor is responsible for transferring IgG across cells while protecting it from lysosomal degradation?
Which Fc receptor is responsible for transferring IgG across cells while protecting it from lysosomal degradation?
Which antibody is the most effective in complement-mediated lysis?
Which antibody is the most effective in complement-mediated lysis?
Which process is inhibited by the binding of antibodies to pathogens?
Which process is inhibited by the binding of antibodies to pathogens?
Which type of B cell is responsible for the production of IgM during the primary immune response?
Which type of B cell is responsible for the production of IgM during the primary immune response?
What is the main difference between the primary and secondary immune responses?
What is the main difference between the primary and secondary immune responses?
Which of the following is true about B cell development?
Which of the following is true about B cell development?
What is the primary sign of B cell maturity?
What is the primary sign of B cell maturity?
Which of the following is true about direct antigen acquisition and activation?
Which of the following is true about direct antigen acquisition and activation?
What happens during indirect antigen acquisition and activation?
What happens during indirect antigen acquisition and activation?
Which specialized APCs are involved in capturing antigens and transferring them to B cells?
Which specialized APCs are involved in capturing antigens and transferring them to B cells?
Which type of B cell activation is T-independent?
Which type of B cell activation is T-independent?
What is the role of CD4 T cell help in T-dependent B cell activation?
What is the role of CD4 T cell help in T-dependent B cell activation?
Where does T cell activation and B cell activation occur in the lymph node?
Where does T cell activation and B cell activation occur in the lymph node?
What happens during T-B cell interactions in the lymph node follicles?
What happens during T-B cell interactions in the lymph node follicles?
What is the outcome of T-B cell interactions in the lymph node follicles?
What is the outcome of T-B cell interactions in the lymph node follicles?
