Lecture 2 of B Cells
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Questions and Answers

Where do B cells encounter antigens on subcapsular sinus macrophages?

  • Germinal center
  • Border of B and T cell zone (correct)
  • T cell zone
  • Blood vessels
  • Which region of the lymph node is associated with the Signal 2 that B cells receive

  • T cell zone
  • B cell zone
  • Border of B and T cell zone (correct)
  • Subcapsular sinus
  • In which part of the lymph node do T cells get activated by interacting with DCs?

  • Germinal center
  • T cell zone (correct)
  • Subcapsular sinus
  • B cell zone
  • Where do B cells undergo the later stages of proliferation and differentiation in the lymph node?

    <p>Germinal center</p> Signup and view all the answers

    Which part of the lymph node is associated with the development of B cells?

    <p>Germinal center</p> Signup and view all the answers

    Where do germinal center reactions take place in the lymph node?

    <p>Germinal center</p> Signup and view all the answers

    Which part of a lymph node do free-floating antigens interact with B cells?

    <p>Subcapsular sinus</p> Signup and view all the answers

    Where are signals that direct B cells to appropriate locations during different stages in a lymph node?

    <p>Subcapsular sinus</p> Signup and view all the answers

    During B cell activation, which region of the lymph node is described as having a lot of fluid where many antigens are processed?

    <p>Subcapsular sinus</p> Signup and view all the answers

    Which area of a lymph node is responsible for where antigens and immune cells can enter and exit?

    <p>T cell zone</p> Signup and view all the answers

    What is the main outcome of an activated B cell migrating to form a primary focus in the subcapsular region?

    <p>Proliferation and differentiation into plasmablasts</p> Signup and view all the answers

    What is the primary function of germinal centers in secondary lymphoid follicles?

    <p>Somatic hypermutation to increase antibody specificity</p> Signup and view all the answers

    Which cells secrete antibodies mainly with low affinity, such as IgM, during early antibody production?

    <p>Plasmablasts</p> Signup and view all the answers

    What is the significance of CD40/CD40L interaction at the T/B cell border?

    <p>Facilitation of signal 2 to activated B cells</p> Signup and view all the answers

    What determines whether a plasmablast will migrate to the bone marrow and become a plasma cell?

    <p>Continued antibody production</p> Signup and view all the answers

    What is the main role of follicular DCs in the activation of B cells?

    <p>Present antigens to B cells</p> Signup and view all the answers

    What occurs at the T-B border that leads to B cell activation?

    <p>Expression of chemokine receptor</p> Signup and view all the answers

    What is the main function of memory B cells in the immune response?

    <p>Facilitate faster reactions upon re-exposure to antigen</p> Signup and view all the answers

    Which process allows for B cell receptors to rearrange genetically for higher affinity to antigens?

    <p>Somatic hypermutation</p> Signup and view all the answers

    In the absence of CD40 molecule expression, what outcome is expected on stimulation with a T-dependent antigen?

    <p>Impaired priming of antigen-specific B cell responses</p> Signup and view all the answers

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