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Questions and Answers
Where do B cells encounter antigens on subcapsular sinus macrophages?
Where do B cells encounter antigens on subcapsular sinus macrophages?
- Germinal center
- Border of B and T cell zone (correct)
- T cell zone
- Blood vessels
Which region of the lymph node is associated with the Signal 2 that B cells receive
Which region of the lymph node is associated with the Signal 2 that B cells receive
- T cell zone
- B cell zone
- Border of B and T cell zone (correct)
- Subcapsular sinus
In which part of the lymph node do T cells get activated by interacting with DCs?
In which part of the lymph node do T cells get activated by interacting with DCs?
- Germinal center
- T cell zone (correct)
- Subcapsular sinus
- B cell zone
Where do B cells undergo the later stages of proliferation and differentiation in the lymph node?
Where do B cells undergo the later stages of proliferation and differentiation in the lymph node?
Which part of the lymph node is associated with the development of B cells?
Which part of the lymph node is associated with the development of B cells?
Where do germinal center reactions take place in the lymph node?
Where do germinal center reactions take place in the lymph node?
Which part of a lymph node do free-floating antigens interact with B cells?
Which part of a lymph node do free-floating antigens interact with B cells?
Where are signals that direct B cells to appropriate locations during different stages in a lymph node?
Where are signals that direct B cells to appropriate locations during different stages in a lymph node?
During B cell activation, which region of the lymph node is described as having a lot of fluid where many antigens are processed?
During B cell activation, which region of the lymph node is described as having a lot of fluid where many antigens are processed?
Which area of a lymph node is responsible for where antigens and immune cells can enter and exit?
Which area of a lymph node is responsible for where antigens and immune cells can enter and exit?
What is the main outcome of an activated B cell migrating to form a primary focus in the subcapsular region?
What is the main outcome of an activated B cell migrating to form a primary focus in the subcapsular region?
What is the primary function of germinal centers in secondary lymphoid follicles?
What is the primary function of germinal centers in secondary lymphoid follicles?
Which cells secrete antibodies mainly with low affinity, such as IgM, during early antibody production?
Which cells secrete antibodies mainly with low affinity, such as IgM, during early antibody production?
What is the significance of CD40/CD40L interaction at the T/B cell border?
What is the significance of CD40/CD40L interaction at the T/B cell border?
What determines whether a plasmablast will migrate to the bone marrow and become a plasma cell?
What determines whether a plasmablast will migrate to the bone marrow and become a plasma cell?
What is the main role of follicular DCs in the activation of B cells?
What is the main role of follicular DCs in the activation of B cells?
What occurs at the T-B border that leads to B cell activation?
What occurs at the T-B border that leads to B cell activation?
What is the main function of memory B cells in the immune response?
What is the main function of memory B cells in the immune response?
Which process allows for B cell receptors to rearrange genetically for higher affinity to antigens?
Which process allows for B cell receptors to rearrange genetically for higher affinity to antigens?
In the absence of CD40 molecule expression, what outcome is expected on stimulation with a T-dependent antigen?
In the absence of CD40 molecule expression, what outcome is expected on stimulation with a T-dependent antigen?
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