B Cell Activation and Differentiation
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Questions and Answers

What is the role of a mature naive B cell during the initial encounter with a pathogen?

  • Act as an antigen-presenting cell (correct)
  • Secrete antibodies to fight the pathogen
  • Recognize the MHC II–antigen complex
  • Differentiate into memory B cells

What activates the B cell during the encounter with a pathogen?

  • Differentiation into plasma B cells
  • Recognition of MHC II–antigen complex by helper T cells (correct)
  • Antigen secretion
  • Recognition of MHC II–antigen complex by memory B cells

What is the role of memory B cells in fighting against the pathogen?

  • Act as an antigen-presenting cell
  • Secrete antibodies to fight the pathogen (correct)
  • Internalize and digest the antigen
  • Differentiate into plasma cells

What differentiates into memory B cells and plasma cells during the encounter with a pathogen?

<p>B cells (C)</p> Signup and view all the answers

What do plasma B cells do in response to a pathogen?

<p>Secrete antibodies to fight against the pathogen (D)</p> Signup and view all the answers

What is the function of a helper T cell during the initial encounter with a pathogen?

<p>Recognize the MHC II–antigen complex and activate the B cell (B)</p> Signup and view all the answers

What happens to memory B cells after the initial infection?

<p>Remain in the body for subsequent exposures to generate a faster, stronger response (A)</p> Signup and view all the answers

What leads to differentiation into plasma B cells and memory B cells?

<p>(MHC II) molecule and activation by helper T cells (C)</p> Signup and view all the answers

What is the main advantage of using one enzyme-linked anti-mouse 2Ëš antibody instead of labeling each of the 5 different mouse 1Ëš antibodies with an enzyme?

<p>Reduced cost and time associated with labeling each antibody individually (C)</p> Signup and view all the answers

Which region of the antibody does the enzyme-linked anti-mouse 2Ëš antibody bind to?

<p>Fc region (B)</p> Signup and view all the answers

In lateral flow immunoassay, what is the purpose of the chicken IgY antibodies present in the conjugation pad?

<p>To act as a negative control (D)</p> Signup and view all the answers

What is the significance of the appearance of a colored line on the control line in lateral flow immunoassay?

<p>It indicates that insufficient sample volume was used (C)</p> Signup and view all the answers

What happens when antigen in the sample solution flows through a lateral flow immunoassay?

<p>It binds to tagged antibodies along the way (A)</p> Signup and view all the answers

What is the function of excess tagged antibodies in a lateral flow immunoassay?

<p>They bind to surface-bound antibodies at the control line (D)</p> Signup and view all the answers

What is common to both monoclonal and polyclonal antibodies used for research?

<p>They can be used in lateral flow immunoassay (C)</p> Signup and view all the answers

What is the role of antibody-bound antigens in a lateral flow immunoassay?

<p>They bind specifically to tagged antibodies at the test line (A)</p> Signup and view all the answers

What is the result of the random gene recombination and mRNA splicing in the antigen-binding sites?

<p>Tremendous diversity (B)</p> Signup and view all the answers

What is the function of complement proteins in the blood?

<p>They destroy pathogens by opening pores in their membranes (C)</p> Signup and view all the answers

What is the advantage of using enzyme-labeled 2Ëš antibodies?

<p>They can bind to different 1Ëš antibodies from the same organism (D)</p> Signup and view all the answers

What happens when antibodies bind to different pathogens?

<p>The clumping of pathogens increases their removal by phagocytosis (B)</p> Signup and view all the answers

What type of immune system do antibodies belong to?

<p>Adaptive immune system (B)</p> Signup and view all the answers

What do certain complement proteins do to pathogens?

<p>They form attack complexes that destroy pathogens by opening pores in their membranes (B)</p> Signup and view all the answers

What results from binding of antibodies to different pathogens?

<p>Clumping of pathogens resulting in increased removal by phagocytosis (C)</p> Signup and view all the answers

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