T Cell-Mediated Immunity Quiz
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Questions and Answers

What is the main function of co-stimulatory molecules in T cell activation?

  • Inactivate T cells in the absence of antigen recognition
  • Enhance TCR binding to peptide:MHC complex
  • Stabilize interaction between T cell and APC
  • Provide additional signal for T cell proliferation and differentiation (correct)

    • What is the consequence of antigen recognition in the absence of co-stimulation for T cells?

  • Inactivation (anergy) (correct)
  • Increased binding to APCs
  • Immediate differentiation into effector T cells
  • Enhanced proliferation

    • Which molecules are involved in stabilizing the interaction between T cell and APC?

  • Co-stimulatory molecules and TCR
  • Adhesion molecules and specific antigen recognition (correct)
  • B7.1 (CD80) and B7.2 (CD86)
  • CD4 and CD8 co-receptors

    • What is the function of armed effector T cells?

    <p>Respond to their specific antigen without co-stimulation</p> Signup and view all the answers

    Which cells aid in the clonal expansion of CD8 T cells?

    <p>CD4 cells</p> Signup and view all the answers

    What is the role of CD8 co-receptors in T cell activation?

    <p>Enhance TCR binding to peptide:MHC complex</p> Signup and view all the answers

    What is the function of B7.1 (CD80) and B7.2 (CD86) molecules?

    <p>Provide co-stimulatory signals to T cells</p> Signup and view all the answers

    What is the consequence of T cell interaction with APC in the absence of specific antigen recognition?

    <p>Transient interaction</p> Signup and view all the answers

    Which molecule acts as a growth factor for T cell proliferation and differentiation?

    <p>IL-2</p> Signup and view all the answers

    What is the consequence of T cell antigen recognition in the absence of co-stimulation?

    <p>Inactivation (anergy)</p> Signup and view all the answers

    What is the primary function of TCR in T cell activation?

    <p>Binding to peptide:MHC complex</p> Signup and view all the answers

    Which molecule is found exclusively on the surfaces of cells that stimulate T cell proliferation?

    <p>CD86</p> Signup and view all the answers

    What is the receptor for B7 on T cell?

    <p>CD28</p> Signup and view all the answers

    Which molecule binds CD40 on APC and activates the T cell while signaling the APC to express more B7?

    <p>CD40 ligand</p> Signup and view all the answers

    Which molecule, when activated, can bind to B7 on APC with great affinity and delivers an inhibitory signal to T cell?

    <p>CTLA-4</p> Signup and view all the answers

    What do mature dendritic cells lose the ability to do?

    <p>Pick up any more antigen</p> Signup and view all the answers

    Which molecule is responsible for attracting T cells by secreting chemokine CCL18?

    <p>Mature dendritic cells</p> Signup and view all the answers

    Which molecule binds to TLR4 on APC when LPS from gram-negative bacteria is present?

    <p>LPS</p> Signup and view all the answers

    Which molecule is found intracellularly and is activated by bacterial DNA to produce cytokines?

    <p>TLR9</p> Signup and view all the answers

    Which type of pathogen can dendritic cells present antigen from?

    <p>Fungal, bacterial, and viral pathogens</p> Signup and view all the answers

    What determines whether humoral or cell-mediated immunity will predominate?

    <p>Differentiation of CD4 cells into Th1 or Th2</p> Signup and view all the answers

    Which molecule influences the differentiation of the responding T cell based on the type of pathogen?

    <p>Effector molecules synthesized by activated/mature DC</p> Signup and view all the answers

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