22 Questions
What is the main function of co-stimulatory molecules in T cell activation?
Provide additional signal for T cell proliferation and differentiation
What is the consequence of antigen recognition in the absence of co-stimulation for T cells?
Inactivation (anergy)
Which molecules are involved in stabilizing the interaction between T cell and APC?
Adhesion molecules and specific antigen recognition
What is the function of armed effector T cells?
Respond to their specific antigen without co-stimulation
Which cells aid in the clonal expansion of CD8 T cells?
CD4 cells
What is the role of CD8 co-receptors in T cell activation?
Enhance TCR binding to peptide:MHC complex
What is the function of B7.1 (CD80) and B7.2 (CD86) molecules?
Provide co-stimulatory signals to T cells
What is the consequence of T cell interaction with APC in the absence of specific antigen recognition?
Transient interaction
Which molecule acts as a growth factor for T cell proliferation and differentiation?
IL-2
What is the consequence of T cell antigen recognition in the absence of co-stimulation?
Inactivation (anergy)
What is the primary function of TCR in T cell activation?
Binding to peptide:MHC complex
Which molecule is found exclusively on the surfaces of cells that stimulate T cell proliferation?
CD86
What is the receptor for B7 on T cell?
CD28
Which molecule binds CD40 on APC and activates the T cell while signaling the APC to express more B7?
CD40 ligand
Which molecule, when activated, can bind to B7 on APC with great affinity and delivers an inhibitory signal to T cell?
CTLA-4
What do mature dendritic cells lose the ability to do?
Pick up any more antigen
Which molecule is responsible for attracting T cells by secreting chemokine CCL18?
Mature dendritic cells
Which molecule binds to TLR4 on APC when LPS from gram-negative bacteria is present?
LPS
Which molecule is found intracellularly and is activated by bacterial DNA to produce cytokines?
TLR9
Which type of pathogen can dendritic cells present antigen from?
Fungal, bacterial, and viral pathogens
What determines whether humoral or cell-mediated immunity will predominate?
Differentiation of CD4 cells into Th1 or Th2
Which molecule influences the differentiation of the responding T cell based on the type of pathogen?
Effector molecules synthesized by activated/mature DC
Test your knowledge of T cell-mediated immunity in immunology with this quiz covering topics such as dendritic cells, co-stimulatory molecules, peptide:MHC complexes, T cell receptors, macrophages, naive T cells, B cells, and effector T cells. Assess your understanding of the initial interaction between T cells and antigen-presenting cells, including adhesion molecules and specific antigen recognition.
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