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Questions and Answers
What is the main function of co-stimulatory molecules in T cell activation?
What is the main function of co-stimulatory molecules in T cell activation?
- Inactivate T cells in the absence of antigen recognition
- Enhance TCR binding to peptide:MHC complex
- Stabilize interaction between T cell and APC
- Provide additional signal for T cell proliferation and differentiation (correct)
What is the consequence of antigen recognition in the absence of co-stimulation for T cells?
What is the consequence of antigen recognition in the absence of co-stimulation for T cells?
- Inactivation (anergy) (correct)
- Increased binding to APCs
- Immediate differentiation into effector T cells
- Enhanced proliferation
Which molecules are involved in stabilizing the interaction between T cell and APC?
Which molecules are involved in stabilizing the interaction between T cell and APC?
- Co-stimulatory molecules and TCR
- Adhesion molecules and specific antigen recognition (correct)
- B7.1 (CD80) and B7.2 (CD86)
- CD4 and CD8 co-receptors
What is the function of armed effector T cells?
What is the function of armed effector T cells?
Which cells aid in the clonal expansion of CD8 T cells?
Which cells aid in the clonal expansion of CD8 T cells?
What is the role of CD8 co-receptors in T cell activation?
What is the role of CD8 co-receptors in T cell activation?
What is the function of B7.1 (CD80) and B7.2 (CD86) molecules?
What is the function of B7.1 (CD80) and B7.2 (CD86) molecules?
What is the consequence of T cell interaction with APC in the absence of specific antigen recognition?
What is the consequence of T cell interaction with APC in the absence of specific antigen recognition?
Which molecule acts as a growth factor for T cell proliferation and differentiation?
Which molecule acts as a growth factor for T cell proliferation and differentiation?
What is the consequence of T cell antigen recognition in the absence of co-stimulation?
What is the consequence of T cell antigen recognition in the absence of co-stimulation?
What is the primary function of TCR in T cell activation?
What is the primary function of TCR in T cell activation?
Which molecule is found exclusively on the surfaces of cells that stimulate T cell proliferation?
Which molecule is found exclusively on the surfaces of cells that stimulate T cell proliferation?
What is the receptor for B7 on T cell?
What is the receptor for B7 on T cell?
Which molecule binds CD40 on APC and activates the T cell while signaling the APC to express more B7?
Which molecule binds CD40 on APC and activates the T cell while signaling the APC to express more B7?
Which molecule, when activated, can bind to B7 on APC with great affinity and delivers an inhibitory signal to T cell?
Which molecule, when activated, can bind to B7 on APC with great affinity and delivers an inhibitory signal to T cell?
What do mature dendritic cells lose the ability to do?
What do mature dendritic cells lose the ability to do?
Which molecule is responsible for attracting T cells by secreting chemokine CCL18?
Which molecule is responsible for attracting T cells by secreting chemokine CCL18?
Which molecule binds to TLR4 on APC when LPS from gram-negative bacteria is present?
Which molecule binds to TLR4 on APC when LPS from gram-negative bacteria is present?
Which molecule is found intracellularly and is activated by bacterial DNA to produce cytokines?
Which molecule is found intracellularly and is activated by bacterial DNA to produce cytokines?
Which type of pathogen can dendritic cells present antigen from?
Which type of pathogen can dendritic cells present antigen from?
What determines whether humoral or cell-mediated immunity will predominate?
What determines whether humoral or cell-mediated immunity will predominate?
Which molecule influences the differentiation of the responding T cell based on the type of pathogen?
Which molecule influences the differentiation of the responding T cell based on the type of pathogen?
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