Recent Lessons

Show all results for ""

Feature Overview

Ace your exams with our all-in-one platform for creating and sharing quizzes and tests.

Quizzes

Create quizzes and tests automatically from your content using AI.

Flashcards

Automatically turn your notes into digital flashcards.

Share, Export & Embed

Share with classmates or export to Excel and your learning management system.

Stats & Reporting

Auto-grading quizzes and tests with detailed stats and reports.

Mobile Apps

The smarter way to study – wherever you are.

Pricing

Search...

17 Questions

2 Views

Lecture 4 B Cells

Choose a study mode

Play Quiz

Study Flashcards

Spaced Repetition

Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the role of RAG-1 and RAG-2 in V(D)J recombination?

Creating signal joint and coding joint at the DNA level

Recognizing and cutting DNA at the immunoglobulin-encoding region and the RSS (correct)

Adding N-nucleotides to the cleaved strands

Removing nonmatching nucleotides and filling in gaps

What enzyme primarily adds up to 20 N-nucleotides (non-template encoded) to the cleaved strands during V(D)J recombination?

Exonuclease

Artemis

RAG-1

Terminal Deoxynucleotidyl Transferase (TdT) (correct)

Which process leads to diversity in the length of Complementarity Determining Regions (CDRs)?

Repair enzymes trimming off nonmatching nucleotides

Addition of palindromic nucleotides at overhangs

Terminal Deoxynucleotidyl Transferase (TdT) activity (correct)

Exonuclease removing nucleotides

What is the result of a deficiency in Terminal Deoxynucleotidyl Transferase (TdT) during V(D)J recombination?

Decreased N-nucleotide addition to V-D and D-J junctions Signup and view all the answers

Which enzyme is responsible for opening DNA hairpins during V(D)J recombination?

Artemis Signup and view all the answers

What is the function of Covalently closed DNA hairpin ends?

Excision of loops Signup and view all the answers

What is notable about the Junctional Diversity process during V(D)J recombination?

Nucleotides may be added or removed at junctions between V, D, and J regions Signup and view all the answers

Which proteins are crucial for creating signal joint and coding joint during V(D)J recombination?

[RAG-1, RAG-2] Signup and view all the answers

'Many copies of V, D, and J are encoded in the germline' - This statement refers to which type of diversity in V(D)J recombination?

[Combinatorial Diversity] Signup and view all the answers

What is the process by which segments are rearranged in every single B cell to create different possible antibodies?

Somatic recombination Signup and view all the answers

In B cells, which region of the antibody defines the specificity of the binding sites?

Variable region Signup and view all the answers

What is the function of recombinase enzymes like RAG1/2 in B cell development?

Recognize RSSs to cleave DNA for recombination Signup and view all the answers

Which region of the Heavy chain gene segments is exclusive to heavy chains only?

Diversity (D) Signup and view all the answers

What dictates the pairing of different segments together during gene rearrangement of BCRs?

Recombination signal sequences (RSSs) Signup and view all the answers

Which rule states that a 12-bp RSS must pair with a 23-bp RSS for recombination to occur?

12/23 Rule Signup and view all the answers

In the light chain gene rearrangement, what is unique about the constant regions?

They come from V segments Signup and view all the answers

How many different Ig isotypes are associated with the light chains of B cell receptors?

$2$ Signup and view all the answers