17 Questions
Which antigen is often seen with abnormalities of chromosome 11q23 in B-ALL and is associated with a bad prognosis?
CD79a
What is the significance of TdT in B-ALL?
Early precursor stage often expresses TdT.
Which antigen is commonly expressed in both T-cell and B-cell in B-ALL?
HLA-DR (Human Leukocyte Antigen-DR)
What are some of the lineage nonspecific antigens in B-ALL?
CD34 and TdT
Which antigens are associated with the maturation stage in B-ALL?
CD10, CD19, CD22
What are some of the aberrant (myeloid) antigens in B-ALL?
CD13, CD33, CD15
What is the favorable age range for B-ALL prognosis?
4-10 years
What is the unfavorable age range for B-ALL prognosis?
10 years
Which genetic abnormality is associated with a favorable prognosis in B-ALL?
Hyperdiploidy >50 chromosomes
Which genetic abnormality is associated with an unfavorable prognosis in B-ALL?
t(4;11)(q21;q23)
What are the common cytochemistry characteristics of T-ALL?
Positive for Acid Phosphatase, Negative for Myeloperoxidase
What are the cells of the immune system involved in childhood and adolescence disease?
B cells and T cells
What is the gene translocation associated with B cell precursor acute lymphoblastic leukemia?
TEL-AML1 fusion gene (t(12;21) (p13;q22))
How are abnormal cells in the peripheral blood and/or bone marrow identified?
As blasts (young cells)
Which cytochemistry staining is negative in B cell precursor acute lymphoblastic leukemia?
Myeloperoxidase (MPO)
What are the immunologic markers associated with B-ALL?
CD19 and CD22
What chromosomal abnormality is linked to B-ALL?
Chromosome 11q23
Test your knowledge about commonly expressed antigens in B-ALL, including B lymphocyte antigens like CD19, CD22, CD79a, and more. Learn about lineage nonspecific antigens, terminal antigens, and aberrant (myeloid) antigens associated with B-ALL. Explore antigenic patterns and maturation stage associations in B-ALL.
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