B-ALL Antigens Quiz
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Questions and Answers

Which antigen is often seen with abnormalities of chromosome 11q23 in B-ALL and is associated with a bad prognosis?

CD79a

What is the significance of TdT in B-ALL?

Early precursor stage often expresses TdT.

Which antigen is commonly expressed in both T-cell and B-cell in B-ALL?

HLA-DR (Human Leukocyte Antigen-DR)

What are some of the lineage nonspecific antigens in B-ALL?

<p>CD34 and TdT</p> Signup and view all the answers

Which antigens are associated with the maturation stage in B-ALL?

<p>CD10, CD19, CD22</p> Signup and view all the answers

What are some of the aberrant (myeloid) antigens in B-ALL?

<p>CD13, CD33, CD15</p> Signup and view all the answers

What is the favorable age range for B-ALL prognosis?

<p>4-10 years</p> Signup and view all the answers

What is the unfavorable age range for B-ALL prognosis?

<p>10 years</p> Signup and view all the answers

Which genetic abnormality is associated with a favorable prognosis in B-ALL?

<p>Hyperdiploidy &gt;50 chromosomes</p> Signup and view all the answers

Which genetic abnormality is associated with an unfavorable prognosis in B-ALL?

<p>t(4;11)(q21;q23)</p> Signup and view all the answers

What are the common cytochemistry characteristics of T-ALL?

<p>Positive for Acid Phosphatase, Negative for Myeloperoxidase</p> Signup and view all the answers

What are the cells of the immune system involved in childhood and adolescence disease?

<p>B cells and T cells</p> Signup and view all the answers

What is the gene translocation associated with B cell precursor acute lymphoblastic leukemia?

<p>TEL-AML1 fusion gene (t(12;21) (p13;q22))</p> Signup and view all the answers

How are abnormal cells in the peripheral blood and/or bone marrow identified?

<p>As blasts (young cells)</p> Signup and view all the answers

Which cytochemistry staining is negative in B cell precursor acute lymphoblastic leukemia?

<p>Myeloperoxidase (MPO)</p> Signup and view all the answers

What are the immunologic markers associated with B-ALL?

<p>CD19 and CD22</p> Signup and view all the answers

What chromosomal abnormality is linked to B-ALL?

<p>Chromosome 11q23</p> Signup and view all the answers

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