5 Questions
What is the laboratory finding that defines azotemia?
Increased nitrogenous waste products
What clinical manifestations define uremia?
Symptoms of azotemia
What does a significantly reduced GFR result in?
Increased nitrogenous waste products retention
What are the possible causes of significantly reduced GFR?
Postrenal processes
In azotemia, what is attributed to the inability of the renal system to filter?
Increased nitrogenous waste products
Study Notes
Azotemia and Uremia
- Azotemia is a laboratory finding characterized by increased levels of nitrogenous waste products, such as creatinine and urea, due to the kidneys' inability to filter waste (decreased GFR).
- Uremia refers to the clinical manifestations of azotemia, which can develop at varying levels of plasma creatinine depending on individual factors, including size, age, sex, underlying disease, concurrent illness, and true GFR.
Causes of Reduced GFR
- A significantly reduced GFR can result from:
- Reduced renal perfusion
- Intrinsic renal disease
- Postrenal processes (ureteral obstruction)
Consequences of Reduced GFR
- A reduced GFR leads to a rise in serum creatinine.
- It results in the retention of nitrogenous waste products, such as urea, in the body.
Learn about the differences between azotemia, uremia, and reduced glomerular filtration rate (GFR). Understand how each condition is characterized by laboratory findings, clinical manifestations, and impact on nitrogenous waste product retention.
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