Podcast
Questions and Answers
What is the classification of Azathioprine?
What is the indication for Azathioprine?
Adjunct for the prevention of renal transplant rejection and treatment of severe, active, erosive rheumatoid arthritis.
What actions does Azathioprine perform?
Inhibits purine synthesis, leading to decreased DNA and RNA production in white blood cells.
What are the therapeutic effects of Azathioprine?
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Which of the following are adverse reactions/side effects of Azathioprine? (Select all that apply)
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What are the contraindications for Azathioprine?
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What are the nursing implications for patients on Azathioprine?
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What should be included in patient/family teaching regarding Azathioprine?
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Study Notes
Azathioprine/Imuran Overview
- Azathioprine, also known as Imuran, is classified as an immunosuppressant.
Indications
- Used adjunctively for preventing renal transplant rejection.
- Treats severe, active, erosive Rheumatoid Arthritis (RA).
Mechanism of Action
- Inhibits purine synthesis, which is essential for the production of DNA and RNA.
- Reduces synthesis of white blood cells (WBCs) by limiting DNA and RNA production, leading to immunosuppression.
Therapeutic Effects
- Results in suppression of cell-mediated immunity.
- Alters antibody formation.
Adverse Reactions/Side Effects
- Risk of progressive multifocal leukoencephalopathy.
- Common side effects include anorexia, hepatotoxicity, nausea, vomiting, and malignancy.
- Additional side effects: serum sickness, chills, and fever.
Contraindications
- Not suitable for individuals with hypersensitivity.
- Avoid concurrent use with mycophenolate, another immunosuppressant.
- Can cause fetal harm and is found in breast milk.
Nursing Implications
- Protect transplant patients from infections; maintain protective isolation.
- Oral dosage may be taken with or after meals to minimize nausea and can be given in divided doses.
Patient/Family Teaching
- Encourage patients to report symptoms like unusual tiredness, cough, fever, lower back pain, and signs of transplant rejection.
- Emphasize the need for lifelong therapy and consult healthcare providers before taking new medications or vaccines.
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Description
This quiz focuses on the drug Azathioprine (Imuran), an immunosuppressant used to prevent renal transplant rejection and treat severe rheumatoid arthritis. It covers its classification, indications, and mechanisms of action. Perfect for those studying pharmacology or medicine.
