Autonomic Nervous System Physiology
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Questions and Answers

Which receptor type primarily mediates vasoconstriction in peripheral resistance?

  • β1
  • α1 (correct)
  • β2
  • α2
  • What effect does β2 adrenergic receptor activation have on the respiratory system?

  • Bronchoconstriction
  • Increased mucus secretion
  • Vasoconstriction
  • Bronchodilatation (correct)
  • Which of the following tissues primarily demonstrates the inhibition mediated by β2 receptors?

  • Heart
  • Uterus (correct)
  • Gastrointestinal tract (correct)
  • Skeletal muscle
  • In which of the following situations would you expect reduced renin release?

    <p>Activation of α2 receptors (C)</p> Signup and view all the answers

    What is the primary outcome of stimulating β1 adrenergic receptors in the heart?

    <p>Increased contractility (C)</p> Signup and view all the answers

    Which receptor type is responsible for the contraction of smooth muscle cells in the juxtaglomerular apparatus of the kidney?

    <p>α1 (A)</p> Signup and view all the answers

    What effect do α2 presynaptic receptors have on noradrenaline release from postganglionic adrenergic nerve endings?

    <p>Decrease the release of noradrenaline (D)</p> Signup and view all the answers

    Which muscle in the eye is relaxed due to β2 receptor activation?

    <p>Ciliary muscle (A)</p> Signup and view all the answers

    Which of the following best describes the action of α1 receptors on GIT sphincters?

    <p>Promote contraction of the sphincters (A)</p> Signup and view all the answers

    What is the end result of the actions of angiotensin II and aldosterone released from renal processes?

    <p>Increase in blood volume (B)</p> Signup and view all the answers

    Which type of cholinergic receptor is classified as ionotropic?

    <p>Nicotinic receptors (A)</p> Signup and view all the answers

    What is the primary agonist for muscarinic receptors?

    <p>Muscarine (B)</p> Signup and view all the answers

    Where are nicotinic receptors primarily located?

    <p>Autonomic ganglia and CNS (C)</p> Signup and view all the answers

    Which receptor class is involved in mediating innervation to visceral organs?

    <p>Muscarinic receptors (B)</p> Signup and view all the answers

    What distinguishes the signal transduction of nicotinic receptors from muscarinic receptors?

    <p>Nicotinic receptors are ligand-gated and muscarinic are G-protein coupled (B)</p> Signup and view all the answers

    Which of the following statements is true about cholinergic fibers?

    <p>All sympathetic preganglionic neurons are cholinergic (D)</p> Signup and view all the answers

    What is the role of muscarinic receptors specifically labeled M1, M2, and M3?

    <p>To mediate excitatory and inhibitory effects in different tissues (D)</p> Signup and view all the answers

    Which category do the receptors NnR and NmR fall under?

    <p>Cholinergic receptors (A)</p> Signup and view all the answers

    What type of receptors are primarily involved in the fight or flight response?

    <p>Adrenergic receptors (C)</p> Signup and view all the answers

    Which adrenergic receptor type is associated with higher affinity towards adrenaline?

    <p>Beta 2 (B)</p> Signup and view all the answers

    Which of the following effects is directly associated with activation of M2 muscarinic receptors in the heart?

    <p>Bradycardia (D)</p> Signup and view all the answers

    What is the primary role of alpha adrenergic receptors in the sympathetic nervous system?

    <p>Stimulation and excitation of organs (B)</p> Signup and view all the answers

    How do beta 1 adrenergic receptors primarily affect the cardiac muscle?

    <p>Increase heart rate and contractility (B)</p> Signup and view all the answers

    What is the mechanism of action for muscarinic receptors in the eye?

    <p>Contraction of ciliary muscle and sphincter pupillae muscle (C)</p> Signup and view all the answers

    What distinguishes alpha receptors from beta receptors in terms of neurotransmitter affinity?

    <p>Alpha receptors have a higher affinity for noradrenaline (D)</p> Signup and view all the answers

    Which subtype of muscarinic receptors has an inhibitory effect?

    <p>M2 (C)</p> Signup and view all the answers

    Flashcards

    Nicotinic Receptors (nAChRs)

    Receptors that bind to acetylcholine, activated by the neurotransmitter acetylcholine, important in the nervous system and muscle contraction.

    Muscarinic Receptors

    Receptors that bind to acetylcholine, activated by the neurotransmitter acetylcholine, important in the parasympathetic nervous system and various bodily functions.

    G protein-coupled receptor

    A type of receptor that utilizes G proteins as signaling molecules.

    Gq protein

    A type of G protein that activates the signaling pathway.

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    Gi protein

    A type of G protein that inhibits the signaling pathway.

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    Adrenergic Receptors

    Receptors that bind to adrenaline and noradrenaline, responsible for the "fight or flight" response.

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    α1 & β1 adrenergic receptors

    A type of adrenergic receptor that activates the signaling pathway.

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    α2 & β2 adrenergic receptors

    A type of adrenergic receptor that inhibits the signaling pathway.

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    Muscarinic Receptor (mAChR)

    A type of cholinergic receptor that is activated by the neurotransmitter acetylcholine and the drug muscarine, and are found in the peripheral and central nervous systems. They are G protein-coupled receptors, meaning they activate intracellular signaling cascades when bound to acetylcholine.

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    Nicotinic Receptor: Ganglionic (NnR)

    This type of nicotinic receptor is found mainly in autonomic ganglia, where preganglionic neurons release acetylcholine to activate postganglionic neurons.

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    Nicotinic Receptor: Neuromuscular (NmR)

    This type of nicotinic receptor is located at the neuromuscular junction, where motor neurons release acetylcholine to stimulate muscle contraction.

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    Muscarinic Receptor Subtypes (M1-M5)

    Named as M1-M5, these subtypes are found in various locations throughout the body, mediating diverse physiological effects. For example, M1 receptors are important for learning and memory in the brain, while M3 receptors influence smooth muscle contraction.

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    Cholinergic Fibers

    These fibers release acetylcholine as a neurotransmitter, playing a crucial role in both sympathetic and parasympathetic nervous systems.

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    Pre-ganglionic Cholinergic Receptors

    A type of acetylcholine receptor that serves as a bridge between the preganglionic neuron and postganglionic neuron in both sympathetic and parasympathetic pathways.

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    Post-ganglionic Cholinergic Receptors

    These receptors are activated by acetylcholine released by postganglionic neurons in the parasympathetic nervous system.

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    Effect of adrenergic receptors on GIT

    β2 receptors on GIT smooth muscles cause relaxation, while α1 receptors cause contraction. This affects both the movement and constriction of the gastrointestinal tract.

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    Effect of adrenergic receptors on GIT sphincters

    β2 receptors on GIT sphincters cause relaxation, while α1 receptors cause constriction. This regulates the flow of food and waste through the digestive system.

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    Effect of adrenergic receptors on the kidneys

    In the kidney, α1 receptors on smooth muscle cells in the juxtaglomerular apparatus cause contraction, leading to the release of renin. This triggers a cascade that increases blood volume.

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    Effect of adrenergic receptors on the eye

    α1 receptors on the dilator pupillae muscle causes contraction, leading to pupil dilation. β2 receptors on the ciliary muscle cause relaxation, resulting in lens accommodation for far vision.

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    Presynaptic α2 receptors

    Presynaptic α2 receptors are located on the postganglionic adrenergic nerve endings and act as auto-receptors. They regulate the release of norepinephrine by negative feedback, reducing its release when stimulated.

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    β1 Receptor

    A subtype of adrenergic receptor primarily found in the heart. It increases heart rate and contractility by stimulating the sinoatrial (SA) node, atrioventricular (AV) node, and ventricular muscle.

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    α1 Receptor

    A subtype of adrenergic receptor that primarily causes vasoconstriction (narrowing of blood vessels) by acting on smooth muscle cells in blood vessel walls.

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    β2 Receptor

    A subtype of adrenergic receptor primarily responsible for smooth muscle relaxation, particularly in the bronchioles (airways) of the lungs, leading to bronchodilation (opening of airways).

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    α2 Receptor

    A subtype of adrenergic receptor primarily involved in inhibiting neurotransmitter release from presynaptic nerve endings. It plays a role in regulating the release of norepinephrine.

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    β3 Receptor

    A type of adrenergic receptor that preferentially promotes lipolysis (breakdown of fats) and glycogenolysis (breakdown of glycogen).

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    Study Notes

    Autonomic Nervous System Physiology

    • The autonomic nervous system (ANS) controls involuntary functions like heart rate, digestion, and breathing.
    • Cholinergic and adrenergic receptors play key roles in the ANS.

    Cholinergic Receptors

    • Cholinergic receptors bind to acetylcholine (ACh).
    • They are categorized into nicotinic and muscarinic receptors.
    • Nicotinic receptors (nAChRs):
      • Ionotropic ligand-gated receptors
      • Respond to ACh and nicotine
      • Found in autonomic ganglia and neuromuscular junctions
    • Muscarinic receptors (mAChRs):
      • G protein-coupled receptors
      • Respond to ACh and muscarine
      • Found in the peripheral and central nervous systems, affecting various organs

    Cholinergic Receptor Function

    • All sympathetic and parasympathetic preganglionic neurons are cholinergic, using ACh.
    • Some sympathetic and all parasympathetic postganglionic neurons release ACh.
    • Key organs and effects are detailed in subsequent sections

    Adrenergic Receptors

    • Adrenergic receptors bind to catecholamines (norepinephrine and epinephrine).
    • They are G protein-coupled receptors.
    • Categorized into alpha (α1, α2) and beta (β1, β2, β3) subtypes.

    Adrenergic Receptor Function

    • Alpha and beta receptors have different effects on different organs.
    • Alpha receptors (α1, α2): Commonly involved in excitation or inhibition.
    • Beta receptors (β1, β2, β3): Often linked to stimulating effects on different organs

    Effects of Cholinergic Receptors

    • M1 receptors: Found in gastric glands, stimulating histamine release and acid secretion. Also affects brain, increasing memory, attention, and emotional responses
    • M3 receptors: Affect GI tract, gallbladder, smooth muscle contraction, and pupil constriction.
    • Gland secretions, promoting eye, mouth, and lung lubrication.

    Effects of Adrenergic Receptors

    • α1 receptors: Involved in vasoconstriction, mydriasis (pupil dilation), piloerector muscle contraction, and GIT and urinary sphincters.
    • α2 receptors: Involved in norepinephrine release, insulin release, myocardial contractility, and renin release.
    • β1 receptors: Affect heart rate and contractility, increasing them.
    • β2 receptors: Involved in vasodilation, bronchodilation, glycogenolysis, urinary bladder relaxation, uterine relaxation, and lipolysis.
    • β3 receptors: Influence lipolysis.

    Presynaptic Receptors

    • Located on the membranes of postganglionic adrenergic nerve endings.
    • Regulate norepinephrine release through negative feedback mechanisms.

    Additional Notes

    • Catecholamines play a crucial role in the fight-or-flight response.
    • Receptor subtypes have distinct functions and are associated with specific responses in various organs (e.g., heart, lungs, GI tract, bladder, eye).
    • These intricacies are significant for understanding pharmacology and diseases related to the ANS.

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    Description

    Explore the key concepts of the autonomic nervous system (ANS), including its control over involuntary functions like heart rate and digestion. This quiz delves into cholinergic receptors, their categories, and functions, emphasizing the roles of nicotinic and muscarinic receptors in the body's response mechanisms.

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