Podcast
Questions and Answers
Which function is NOT primarily regulated by the autonomic nervous system?
Which function is NOT primarily regulated by the autonomic nervous system?
- Regulation of skeletal muscle movement (correct)
- Regulation of heart rate
- Regulation of smooth muscles
- Regulation of secretory glands
A patient is experiencing difficulty focusing on nearby objects. Which part of the nervous system is likely affected?
A patient is experiencing difficulty focusing on nearby objects. Which part of the nervous system is likely affected?
- Somatic motor system
- Central nervous system
- Sympathetic nervous system
- Parasympathetic nervous system (correct)
During a stressful situation, blood is shunted away from the skin and viscera and into skeletal muscles. Which branch of the autonomic nervous system mediates this response?
During a stressful situation, blood is shunted away from the skin and viscera and into skeletal muscles. Which branch of the autonomic nervous system mediates this response?
- Central nervous system
- Somatic motor system
- Sympathetic nervous system (correct)
- Parasympathetic nervous system
Which of the following is a function of the parasympathetic nervous system?
Which of the following is a function of the parasympathetic nervous system?
What is the primary role of vasoconstriction initiated by the sympathetic nervous system in response to blood loss?
What is the primary role of vasoconstriction initiated by the sympathetic nervous system in response to blood loss?
Which of the following mechanisms is used by the sympathetic nervous system to regulate body temperature?
Which of the following mechanisms is used by the sympathetic nervous system to regulate body temperature?
What are the three essential components for a feedback regulation system?
What are the three essential components for a feedback regulation system?
A drug that blocks sympathetic nerve activity would likely have which effect?
A drug that blocks sympathetic nerve activity would likely have which effect?
How do tricyclic antidepressants affect norepinephrine neurotransmission?
How do tricyclic antidepressants affect norepinephrine neurotransmission?
Which of the following is the primary mechanism for terminating the effects of epinephrine?
Which of the following is the primary mechanism for terminating the effects of epinephrine?
A drug that inhibits MAO would have what effect on norepinephrine?
A drug that inhibits MAO would have what effect on norepinephrine?
Epinephrine differs from norepinephrine in that epinephrine:
Epinephrine differs from norepinephrine in that epinephrine:
Which receptors can be activated by epinephrine after it is released into the bloodstream?
Which receptors can be activated by epinephrine after it is released into the bloodstream?
Which physiological response would be expected from the activation of α1 receptors in the eye?
Which physiological response would be expected from the activation of α1 receptors in the eye?
What is the primary effect of activating β1 receptors in the kidney?
What is the primary effect of activating β1 receptors in the kidney?
Which of the following is a consequence of activating muscarinic receptors on blood vessels?
Which of the following is a consequence of activating muscarinic receptors on blood vessels?
How do presynaptic α2 receptors regulate neurotransmitter release in the peripheral nervous system?
How do presynaptic α2 receptors regulate neurotransmitter release in the peripheral nervous system?
A drug that selectively activates β2 receptors would likely have which of the following effects on the bronchi?
A drug that selectively activates β2 receptors would likely have which of the following effects on the bronchi?
What is the expected effect of activating nicotinicM receptors?
What is the expected effect of activating nicotinicM receptors?
Which of the following best describes the location of α2 receptors in the peripheral nervous system?
Which of the following best describes the location of α2 receptors in the peripheral nervous system?
What effect does activation of β2 receptors have on glycogen levels?
What effect does activation of β2 receptors have on glycogen levels?
Which of the following is a direct effect of activating muscarinic receptors in the eye?
Which of the following is a direct effect of activating muscarinic receptors in the eye?
A patient is experiencing difficulty with urination due to bladder sphincter constriction. Which receptor type, when activated, would most likely alleviate this condition?
A patient is experiencing difficulty with urination due to bladder sphincter constriction. Which receptor type, when activated, would most likely alleviate this condition?
Stimulation of which receptor type would result in increased heart rate and force of contraction?
Stimulation of which receptor type would result in increased heart rate and force of contraction?
Activation of nicotinicN receptors results in which of the following?
Activation of nicotinicN receptors results in which of the following?
Which effect would be most likely to occur from the activation of α1 receptors in arterioles?
Which effect would be most likely to occur from the activation of α1 receptors in arterioles?
What is the expected uterine response following activation of β2-adrenergic receptors?
What is the expected uterine response following activation of β2-adrenergic receptors?
Which of the following responses is associated with activation of muscarinic receptors?
Which of the following responses is associated with activation of muscarinic receptors?
Which of the following accurately describes the role of the effector in a reflex arc?
Which of the following accurately describes the role of the effector in a reflex arc?
If blood pressure suddenly increases, what is the expected response of the baroreceptor reflex?
If blood pressure suddenly increases, what is the expected response of the baroreceptor reflex?
Which neurons release acetylcholine (ACh) as a primary neurotransmitter?
Which neurons release acetylcholine (ACh) as a primary neurotransmitter?
Norepinephrine primarily mediates responses at which type of receptor?
Norepinephrine primarily mediates responses at which type of receptor?
If a drug stimulates muscarinic receptors, which of the following responses is MOST likely to occur?
If a drug stimulates muscarinic receptors, which of the following responses is MOST likely to occur?
Which of the following effects would be observed following the activation of nicotinicN receptors?
Which of the following effects would be observed following the activation of nicotinicN receptors?
After administration of d-tubocurarine, acetylcholine is administered. Which effect on ciliary muscle would be expected?
After administration of d-tubocurarine, acetylcholine is administered. Which effect on ciliary muscle would be expected?
Which response is induced by muscarine on the ciliary muscle?
Which response is induced by muscarine on the ciliary muscle?
A drug causes vasodilation but does not directly affect the nervous system. Which receptor is MOST likely being targeted?
A drug causes vasodilation but does not directly affect the nervous system. Which receptor is MOST likely being targeted?
In the context of the autonomic nervous system, what is the functional significance of the adrenal medulla releasing epinephrine?
In the context of the autonomic nervous system, what is the functional significance of the adrenal medulla releasing epinephrine?
What is the combined effect of detrusor muscle contraction and trigone/sphincter relaxation on the bladder?
What is the combined effect of detrusor muscle contraction and trigone/sphincter relaxation on the bladder?
Considering the functions of cholinergic receptor subtypes, which of the following scenarios would MOST likely involve muscarinic receptor activation?
Considering the functions of cholinergic receptor subtypes, which of the following scenarios would MOST likely involve muscarinic receptor activation?
A researcher is developing a drug to specifically target sweat glands. Which neurotransmitter and nervous system branch should be considered?
A researcher is developing a drug to specifically target sweat glands. Which neurotransmitter and nervous system branch should be considered?
A patient is given a medication that blocks nicotinicM receptors. Which of the following side effects is MOST likely?
A patient is given a medication that blocks nicotinicM receptors. Which of the following side effects is MOST likely?
How does the baroreceptor reflex respond to a decrease in blood pressure to maintain homeostasis?
How does the baroreceptor reflex respond to a decrease in blood pressure to maintain homeostasis?
Which of the following is the primary mechanism by which norepinephrine's action is terminated in the synapse?
Which of the following is the primary mechanism by which norepinephrine's action is terminated in the synapse?
A patient is experiencing bronchoconstriction and needs a medication to dilate their bronchioles. Which adrenergic receptor, when activated, would achieve this effect?
A patient is experiencing bronchoconstriction and needs a medication to dilate their bronchioles. Which adrenergic receptor, when activated, would achieve this effect?
Which of the following neurotransmitters can activate alpha 1 ($\alpha_1$), beta 1 ($\beta_1$), and dopamine receptors?
Which of the following neurotransmitters can activate alpha 1 ($\alpha_1$), beta 1 ($\beta_1$), and dopamine receptors?
A researcher is studying the effects of a drug that inhibits acetylcholinesterase (AChE). What direct effect would this drug have on acetylcholine (ACh) levels in the synaptic cleft?
A researcher is studying the effects of a drug that inhibits acetylcholinesterase (AChE). What direct effect would this drug have on acetylcholine (ACh) levels in the synaptic cleft?
Which of the following is NOT a typical effect of Beta 2 ($\beta_2$) receptor activation, considering its role in the 'fight or flight' response?
Which of the following is NOT a typical effect of Beta 2 ($\beta_2$) receptor activation, considering its role in the 'fight or flight' response?
A drug that prevents the storage of norepinephrine within vesicles in the presynaptic neuron would likely lead to:
A drug that prevents the storage of norepinephrine within vesicles in the presynaptic neuron would likely lead to:
Epinephrine is known to activate all alpha ($\alpha$) and beta ($\beta$) receptors EXCEPT dopamine receptors. In a situation requiring increased blood flow to the heart, lungs, and skeletal muscles, which of the following receptors would epinephrine primarily target?
Epinephrine is known to activate all alpha ($\alpha$) and beta ($\beta$) receptors EXCEPT dopamine receptors. In a situation requiring increased blood flow to the heart, lungs, and skeletal muscles, which of the following receptors would epinephrine primarily target?
A patient is prescribed a medication that selectively activates dopamine receptors in the renal vasculature. What therapeutic effect is expected from this medication?
A patient is prescribed a medication that selectively activates dopamine receptors in the renal vasculature. What therapeutic effect is expected from this medication?
Which of the following statements accurately describes a key difference between the life cycle of acetylcholine (ACh) and norepinephrine?
Which of the following statements accurately describes a key difference between the life cycle of acetylcholine (ACh) and norepinephrine?
Monoamine oxidase (MAO) is an enzyme that plays a role in the life cycle of norepinephrine. Where is MAO primarily located, and what is its function?
Monoamine oxidase (MAO) is an enzyme that plays a role in the life cycle of norepinephrine. Where is MAO primarily located, and what is its function?
Botulinum toxin is known to inhibit the release of acetylcholine (ACh). What direct effect would this toxin have on muscle contraction?
Botulinum toxin is known to inhibit the release of acetylcholine (ACh). What direct effect would this toxin have on muscle contraction?
A researcher wants to study the effects of norepinephrine on bronchiolar smooth muscle. Which receptor subtype should they target to observe relaxation of this smooth muscle and bronchodilation?
A researcher wants to study the effects of norepinephrine on bronchiolar smooth muscle. Which receptor subtype should they target to observe relaxation of this smooth muscle and bronchodilation?
A patient presents with symptoms of low blood pressure and decreased heart rate. The physician decides to administer a drug that selectively activates Beta 1 ($\beta_1$) adrenergic receptors. What is the expected therapeutic effect of this drug?
A patient presents with symptoms of low blood pressure and decreased heart rate. The physician decides to administer a drug that selectively activates Beta 1 ($\beta_1$) adrenergic receptors. What is the expected therapeutic effect of this drug?
After norepinephrine is released into the synapse and binds to its receptors, it is transported back into the presynaptic neuron. What are the two possible fates of norepinephrine after reuptake?
After norepinephrine is released into the synapse and binds to its receptors, it is transported back into the presynaptic neuron. What are the two possible fates of norepinephrine after reuptake?
A pregnant woman is experiencing premature uterine contractions. Considering the 'fight or flight' response, which adrenergic receptor agonist could potentially help relax her uterine smooth muscle?
A pregnant woman is experiencing premature uterine contractions. Considering the 'fight or flight' response, which adrenergic receptor agonist could potentially help relax her uterine smooth muscle?
Flashcards
Central Nervous System (CNS)
Central Nervous System (CNS)
The brain and spinal cord; the control center.
Peripheral Nervous System (PNS)
Peripheral Nervous System (PNS)
All nerve fibers outside the brain and spinal cord; connects CNS to limbs and organs.
Somatic Motor System
Somatic Motor System
Division of PNS controlling voluntary movements via skeletal muscles.
Autonomic Nervous System (ANS)
Autonomic Nervous System (ANS)
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Parasympathetic Nervous System
Parasympathetic Nervous System
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Sympathetic Nervous System
Sympathetic Nervous System
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Sympathetic Nervous System effects on the Cardiovascular System
Sympathetic Nervous System effects on the Cardiovascular System
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Feedback Regulation
Feedback Regulation
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Norepinephrine-altering Drugs
Norepinephrine-altering Drugs
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Reuptake Inhibitors' Effect
Reuptake Inhibitors' Effect
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MAO Inhibitors Action
MAO Inhibitors Action
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Epinephrine Synthesis Location
Epinephrine Synthesis Location
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Epinephrine Receptor Targets
Epinephrine Receptor Targets
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Sensor Function
Sensor Function
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Reflex
Reflex
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Baroreceptors
Baroreceptors
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Baroreceptor Reflex (Low BP)
Baroreceptor Reflex (Low BP)
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Baroreceptor Reflex (High BP)
Baroreceptor Reflex (High BP)
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Acetylcholine (ACh)
Acetylcholine (ACh)
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ACh Release Sites
ACh Release Sites
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Norepinephrine
Norepinephrine
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Epinephrine
Epinephrine
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Cholinergic Receptors
Cholinergic Receptors
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Adrenergic Receptors
Adrenergic Receptors
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NicotinicN Receptors
NicotinicN Receptors
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NicotinicM Receptors
NicotinicM Receptors
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Muscarinic Receptors
Muscarinic Receptors
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Muscarinic Effects in the Eye
Muscarinic Effects in the Eye
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α1 Receptor Activation (Eye)
α1 Receptor Activation (Eye)
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α1 Receptor Activation (Arterioles)
α1 Receptor Activation (Arterioles)
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α2 Receptor Function
α2 Receptor Function
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β1 Receptor Activation (Heart)
β1 Receptor Activation (Heart)
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β1 Receptor Activation (Kidney)
β1 Receptor Activation (Kidney)
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β2 Receptor Activation (Arterioles)
β2 Receptor Activation (Arterioles)
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β2 Receptor Activation (Lungs)
β2 Receptor Activation (Lungs)
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β2 Receptor Activation (Uterus)
β2 Receptor Activation (Uterus)
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β2 Receptor Activation (Liver/Muscle)
β2 Receptor Activation (Liver/Muscle)
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Dopamine Receptor Activation (Kidney)
Dopamine Receptor Activation (Kidney)
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NicotinicN Receptor Activation
NicotinicN Receptor Activation
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NicotinicM Receptor Activation
NicotinicM Receptor Activation
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Muscarinic Receptor Activation
Muscarinic Receptor Activation
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Muscarinic Receptor Activation
Muscarinic Receptor Activation
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Muscarinic Receptor Activation
Muscarinic Receptor Activation
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Peripheral Dopamine Receptor Function
Peripheral Dopamine Receptor Function
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Epinephrine Receptor Specificity
Epinephrine Receptor Specificity
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Norepinephrine Receptor Specificity
Norepinephrine Receptor Specificity
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Dopamine Receptor Specificity
Dopamine Receptor Specificity
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Epinephrine and Fight or Flight
Epinephrine and Fight or Flight
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Effects of Beta-2 Activation
Effects of Beta-2 Activation
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ACh Synthesis
ACh Synthesis
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ACh Receptor Binding
ACh Receptor Binding
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ACh Degradation
ACh Degradation
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Choline Reuptake
Choline Reuptake
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Effect of Botulinum Toxin
Effect of Botulinum Toxin
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Norepinephrine Synthesis & Storage
Norepinephrine Synthesis & Storage
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Norepinephrine Receptor Binding
Norepinephrine Receptor Binding
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Termination of Norepinephrine Action
Termination of Norepinephrine Action
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Fate of Norepinephrine After Reuptake
Fate of Norepinephrine After Reuptake
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Study Notes
- The central nervous system consists of the brain and spinal cord.
- The peripheral nervous system includes the somatic motor system and the autonomic nervous system (ANS).
- The autonomic nervous system (ANS) is further divided into the parasympathetic and sympathetic nervous systems.
Autonomic Nervous System (ANS) Functions
- Regulates the heart.
- Regulates secretory glands (salivary, gastric, sweat, and bronchial glands).
- Regulates smooth muscles (bronchi, blood vessels, urogenital system, and gastrointestinal tract).
Parasympathetic Nervous System Functions
- Slows heart rate.
- Increases gastric secretion.
- Empties the bladder.
- Empties the bowel.
- Focuses the eye for near vision.
- Constricts the pupil.
- Contracts bronchial smooth muscle.
Sympathetic Nervous System Functions
- Regulates the cardiovascular system.
- Regulates body temperature.
- Implements the acute stress response (fight-or-flight).
Sympathetic Nervous System and Cardiovascular Regulation
- Maintains blood flow to the brain.
- Redistributes blood flow during exercise.
- Compensates for blood loss via vasoconstriction.
Sympathetic Nervous System and Body Temperature
- Regulates blood flow to the skin to control heat loss: dilation increases heat loss, constriction conserves heat.
- Promotes sweat secretion for cooling.
- Induces piloerection (hair erection) to conserve heat.
Fight-or-Flight Response
- Increases heart rate and blood pressure.
- Shunts blood to skeletal muscles, away from skin and viscera.
- Dilates the bronchi for better oxygenation.
- Dilates the pupils.
- Mobilizes stored energy (glucose for the brain, fatty acids for muscles).
Feedback Regulation
- Allows a system to adjust itself based on incoming information.
- Involves a sensor, an effector, and connecting neurons.
- The sensor monitors physiological processes.
- Information from the sensor is sent to the CNS.
- Signals from the CNS travel along autonomic nerves to the effector.
- The effector makes necessary adjustments.
- The entire process is a reflex.
Feedback Control of Blood Pressure
- Baroreceptors in the carotid sinus and aortic arch monitor blood pressure.
- The brain sends impulses via autonomic nerves to the heart and blood vessels to restore normal blood pressure.
- Low blood pressure triggers vasoconstriction and increased cardiac output.
- High blood pressure triggers vasodilation and reduced cardiac output.
Neurotransmitters: Acetylcholine and Norepinephrine
- Acetylcholine (ACh) is the primary transmitter at most PNS junctions.
- ACh is released by:
- All preganglionic neurons of the parasympathetic nervous system.
- All preganglionic neurons of the sympathetic nervous system.
- All postganglionic neurons of the parasympathetic nervous system.
- All motor neurons to skeletal muscles.
- Most postganglionic neurons of the sympathetic nervous system that go to sweat glands.
- Norepinephrine is released by most postganglionic neurons of the sympathetic nervous system, except those going to sweat glands (which use ACh).
- Epinephrine is mainly released by the adrenal medulla, along with some norepinephrine.
Cholinergic and Adrenergic Receptors
- Cholinergic receptors mediate responses to ACh.
- Adrenergic receptors mediate responses to epinephrine and norepinephrine.
Cholinergic Receptor Subtypes
- NicotinicN: Affects all autonomic nervous system ganglia and the adrenal medulla.
- Activation results in stimulation of parasympathetic and sympathetic postganglionic nerves and epinephrine release.
- NicotinicM: Located at the neuromuscular junction.
- Activation leads to skeletal muscle contraction.
- Muscarinic: Located at all parasympathetic target organs.
- In the Eye:
- Contraction of the ciliary muscle focuses the lens for near vision
- Iris sphincter muscle contraction causes miosis (decreased pupil diameter)
- In the Heart: Decreased rate
- In the Lungs: Constriction of bronchi and promotion of secretions
- In the Bladder: Contraction of detrusor increases bladder pressure, relaxation of trigone and sphincter allows urine to leave the bladder
- In the Gastrointestinal tract: Salivation, increased gastric secretions, increased intestinal tone and motility, and defecation
- In the Sweat glands: Generalized sweating
- In the Sex organs: Erection
- In the Blood vessels: Vasodilation
- In the Eye:
Adrenergic Receptor Subtypes
- α1: Located in the eyes, arterioles, veins, male sex organs, prostatic capsule, and bladder.
- In the Eye: Contraction of the radial muscle of the iris causes mydriasis (increased pupil size)
- In the Arterioles, Skin, Viscera, and Mucous membranes: Constriction
- In the Veins: Constriction
- In the Sex organs (male): Ejaculation
- In the Prostatic capsule: Contraction
- In the Bladder: Contraction of trigone and sphincter
- α2: Located on presynaptic nerve terminals.
- Inhibition of transmitter release
- β1: Located in the heart and kidney.
- In the Heart: Increased rate, force of contraction, and atrioventricular conduction velocity
- In the Kidney: Release of renin
- β2: Located in the arterioles of the heart, lung, and skeletal muscle, as well as in the bronchi, uterus, liver, and skeletal muscle.
- In the Arterioles: Dilation
- In the Bronchi: Dilation
- In the Uterus: Relaxation
- In the Liver: Glycogenolysis
- In the Skeletal muscle: Enhanced contraction, glycogenolysis.
- Dopamine: Located in the kidney.
- Dilation of kidney vasculature
Receptor Specificity of Adrenergic Transmitters
- Epinephrine activates all α and β receptors, but not dopamine receptors.
- Norepinephrine activates α1, α2, and β1 receptors, but not β2 or dopamine receptors.
- Dopamine activates α1, β1, and dopamine receptors.
Transmitter Life Cycles
- Many drugs affect the life cycles of neurotransmitters, influencing their actions.
- Acetylcholine life cycle involves synthesis from choline and acetylcoenzyme A, storage in vesicles, release, binding to receptors (nicotinicN, nicotinicM, or muscarinic), and degradation by acetylcholinesterase (AChE) into acetate and choline.
- The life cycle of norepinephrine involves synthesis, storage in vesicles, release, binding to adrenergic receptors (postsynaptic α1 and β1, presynaptic α2), reuptake into the nerve terminal, and either reuse or inactivation by monoamine oxidase (MAO).
- Epinephrine is synthesized and stored in adrenal medulla cells, released into the bloodstream, activates α1, α2, β1, and β2 receptors, and is terminated primarily by hepatic metabolism rather than neuronal uptake.
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