Autoimmunity and Immunology Learning Objectives
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Questions and Answers

Which of the following is a protective mechanism that prevents the immune system from reacting to its own antigens?

  • Peripheral tolerance
  • Immunological tolerance (correct)
  • Horror autotoxicus
  • Autoimmunity
  • What is the state in which an individual is incapable of developing an immune response against their own tissue antigens?

  • Central tolerance
  • Horror autotoxicus
  • Autoantibodies
  • Immunological tolerance (correct)
  • Which theory of autoimmunity is mediated by the immune system's inability to develop an immune response against its own tissue antigens?

  • Autoimmune diseases
  • Virus obligate
  • Central tolerance (correct)
  • Peripheral tolerance
  • According to Paul Ehrlich, what term describes the body's own immunologically competent cells or antibodies acting against its self-antigens?

    <p>Horror autotoxicus</p> Signup and view all the answers

    During which stage of B cell development does the tolerance to self-antigens primarily occur?

    <p>Receptor editing stage in the bone marrow</p> Signup and view all the answers

    What is the main purpose of central tolerance in the immune system?

    <p>To recognize and tolerate self-antigens</p> Signup and view all the answers

    What happens to developing T cells that express a receptor for self-antigens during their development in the thymus?

    <p>They are negatively selected and deleted by apoptosis</p> Signup and view all the answers

    What is the process by which B cells re-activate the machinery of antigen receptor gene rearrangement to produce a different B cell receptor?

    <p>Receptor editing</p> Signup and view all the answers

    Why is peripheral tolerance important in the immune system?

    <p>To provide counteracting mechanisms for self-reactive T cells escaping central tolerance</p> Signup and view all the answers

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