Autoimmunity and Immunology Learning Objectives

Which of the following is a protective mechanism that prevents the immune system from reacting to its own antigens?

What is the state in which an individual is incapable of developing an immune response against their own tissue antigens?

Which theory of autoimmunity is mediated by the immune system's inability to develop an immune response against its own tissue antigens?

According to Paul Ehrlich, what term describes the body's own immunologically competent cells or antibodies acting against its self-antigens?

During which stage of B cell development does the tolerance to self-antigens primarily occur?

What is the main purpose of central tolerance in the immune system?

What happens to developing T cells that express a receptor for self-antigens during their development in the thymus?

What is the process by which B cells re-activate the machinery of antigen receptor gene rearrangement to produce a different B cell receptor?

Why is peripheral tolerance important in the immune system?