6 Questions
What is the primary cause of autoimmune disorders?
Immune-mediated damage of self tissues
Which type of tolerance leads to T-cell apoptosis or generation of regulatory T cells?
Central tolerance in thymus
What is the function of regulatory T cells in suppressing autoimmunity?
Producing anti-inflammatory cytokines and blocking T-cell activation
What is the US prevalence of autoimmune disorders?
1%-2%
Which mutation results in autoimmune polyendocrine syndrome?
AIRE mutations
What is the function of Fas apoptosis pathway mutations in autoimmune lymphoproliferative syndrome (ALPS)?
Result in autoimmune lymphoproliferative syndrome (ALPS)
Study Notes
Autoimmune Disorders
- The primary cause of autoimmune disorders is unknown, but genetic and environmental factors contribute to the development of these conditions.
Tolerance and Regulatory T Cells
- Central tolerance leads to T-cell apoptosis or generation of regulatory T cells.
Regulatory T Cells
- Regulatory T cells function to suppress autoimmunity by modulating the immune response and maintaining immune homeostasis.
Prevalence of Autoimmune Disorders
- In the US, approximately 24 million people are affected by autoimmune disorders.
Autoimmune Polyendocrine Syndrome
- Mutations in the AIRE gene result in autoimmune polyendocrine syndrome, a rare condition characterized by autoimmune attacks on multiple endocrine glands.
Autoimmune Lymphoproliferative Syndrome (ALPS)
- Mutations in the Fas apoptosis pathway contribute to autoimmune lymphoproliferative syndrome (ALPS), a condition characterized by abnormal lymphocyte survival and autoimmune manifestations.
Test your knowledge on the basic principles of autoimmune disorders, including their prevalence and the loss of self-tolerance. Learn about the role of self-reactive lymphocytes and central tolerance in the development of autoimmune disorders.
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