Podcast
Questions and Answers
What is the primary cause of autoimmune disorders?
What is the primary cause of autoimmune disorders?
Which type of tolerance leads to T-cell apoptosis or generation of regulatory T cells?
Which type of tolerance leads to T-cell apoptosis or generation of regulatory T cells?
What is the function of regulatory T cells in suppressing autoimmunity?
What is the function of regulatory T cells in suppressing autoimmunity?
What is the US prevalence of autoimmune disorders?
What is the US prevalence of autoimmune disorders?
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Which mutation results in autoimmune polyendocrine syndrome?
Which mutation results in autoimmune polyendocrine syndrome?
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What is the function of Fas apoptosis pathway mutations in autoimmune lymphoproliferative syndrome (ALPS)?
What is the function of Fas apoptosis pathway mutations in autoimmune lymphoproliferative syndrome (ALPS)?
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Study Notes
Autoimmune Disorders
- The primary cause of autoimmune disorders is unknown, but genetic and environmental factors contribute to the development of these conditions.
Tolerance and Regulatory T Cells
- Central tolerance leads to T-cell apoptosis or generation of regulatory T cells.
Regulatory T Cells
- Regulatory T cells function to suppress autoimmunity by modulating the immune response and maintaining immune homeostasis.
Prevalence of Autoimmune Disorders
- In the US, approximately 24 million people are affected by autoimmune disorders.
Autoimmune Polyendocrine Syndrome
- Mutations in the AIRE gene result in autoimmune polyendocrine syndrome, a rare condition characterized by autoimmune attacks on multiple endocrine glands.
Autoimmune Lymphoproliferative Syndrome (ALPS)
- Mutations in the Fas apoptosis pathway contribute to autoimmune lymphoproliferative syndrome (ALPS), a condition characterized by abnormal lymphocyte survival and autoimmune manifestations.
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Description
Test your knowledge on the basic principles of autoimmune disorders, including their prevalence and the loss of self-tolerance. Learn about the role of self-reactive lymphocytes and central tolerance in the development of autoimmune disorders.
