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Autoimmune Diseases and Genetics

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Questions and Answers

What is the primary role of genetic susceptibility in autoimmune diseases?

Suppressing T-cell mediated responses

Developing cross-reacting epitopes with self-antigens

Playing an important role in the development of autoimmune diseases (correct)

Triggering infections and tissue injury

What is the term used to describe the phenomenon where the body responds to a microbial antigen and attacks self-tissues?

Self-antigen recognition

Molecular tolerance

Molecular mimicry (correct)

Autoimmune response

What is the result of the breakdown of self-tolerance in autoimmune disorders?

Release of sequestered antigens

Loss of one or more mechanisms of self-tolerance (correct)

Triggering of molecular mimicry

Development of genetic susceptibility

Which of the following is an example of an autoimmune disease triggered by molecular mimicry?

Rheumatic heart disease (D) Signup and view all the answers

What is the role of HLA loci in autoimmune diseases?

Linking autoimmune diseases with genetic susceptibility (D) Signup and view all the answers

What is the term used to describe the display and recognition of self-antigens after tissue injury or infection?

Altered display and recognition of self-antigens (A) Signup and view all the answers