Autacoid and Autacoid Antagonist Quiz
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Questions and Answers

Which enzyme is responsible for the cleavage of arachidonic acid (AA) from membrane-bound phosphatidylcholine?

  • Phospholipase A2 (correct)
  • Prostaglandin
  • Cyclooxygenase
  • Lipoxygenase

Which pathway is responsible for the formation of leukotrienes?

  • Phospholipids pathway
  • Lipoxygenase pathway (correct)
  • Prostacyclin pathway
  • Cyclooxygenase (COX) pathway

Which isoform of the COX enzyme is responsible for basal production of eicosanoids?

  • Lipoxygenase
  • COX-2
  • Phospholipase A2
  • COX-1 (correct)

Which enzyme pathway is associated with asthma and anaphylactic shock?

<p>Lipoxygenase pathway (B)</p> Signup and view all the answers

Which autacoid is also known as a local hormone?

<p>Prostaglandin (D)</p> Signup and view all the answers

Which molecule is cleaved from membrane-bound phosphatidylcholine to form arachidonic acid (AA)?

<p>Phospholipase A2 (A)</p> Signup and view all the answers

Which type of drug has been approved for therapeutic uses on the female reproductive system?

<p>Facilitation of Labor (D)</p> Signup and view all the answers

What is the primary effect of LTC4 and LTD4 on the cardiovascular system?

<p>Reduce myocardial contractility and coronary blood flow (A)</p> Signup and view all the answers

Which drug is used for the treatment of pulmonary hypertension?

<p>COX2-selective inhibitor (D)</p> Signup and view all the answers

What is the primary effect of LTB4 in inflammation?

<p>Adherence and activation of inflammatory cells (B)</p> Signup and view all the answers

Which mediator is responsible for causing bronchoconstriction and increased mucus secretion in the airways?

<p>LTD4 (D)</p> Signup and view all the answers

What is the primary characteristic of asthma?

<p>Inflammation of the airway (B)</p> Signup and view all the answers

What triggers the early asthmatic response?

<p>Release of leukotrienes (B)</p> Signup and view all the answers

What enzyme pathway is targeted by COX2-selective inhibitors?

<p>Cyclooxygenase pathway (C)</p> Signup and view all the answers

Which drug is used to inhibit leukotriene receptors for the treatment of asthma?

<p>Glucocorticoids (D)</p> Signup and view all the answers

Which drug is used for the treatment of erectile dysfunction?

<p>Alprostadil (C)</p> Signup and view all the answers

What is the primary function of autacoids in the body?

<p>Inducing vasodilation (C)</p> Signup and view all the answers

Which enzyme is responsible for the cleavage of arachidonic acid (AA) from membrane-bound phosphatidylcholine?

<p>Phospholipase A2 (C)</p> Signup and view all the answers

Which isoform of the COX enzyme is inducible by cytokines and other inflammatory stimuli?

<p>COX-2 (A)</p> Signup and view all the answers

Which pathway is responsible for the formation of leukotrienes?

<p>Lipoxygenase pathway (D)</p> Signup and view all the answers

Which autacoid is associated with causing bronchoconstriction and increased mucus secretion in the airways?

<p>Leukotrienes (C)</p> Signup and view all the answers

What is the primary effect of thromboxane A2 (TXA2) in the body?

<p>Promoting blood clotting (D)</p> Signup and view all the answers

What is the primary effect of LTB4 in inflammation?

<p>Promotes adherence and activation of inflammatory cells (C)</p> Signup and view all the answers

What triggers the early asthmatic response?

<p>Binding of allergen with IgE on mast cell (D)</p> Signup and view all the answers

Which drug is used for the treatment of pulmonary hypertension?

<p>Leukotrienes receptor inhibitor (B)</p> Signup and view all the answers

What enzyme pathway is responsible for the formation of leukotrienes?

<p>Lipoxygenase pathway (B)</p> Signup and view all the answers

Which drug is used to inhibit leukotriene receptors for the treatment of asthma?

<p>Leukotrienes receptor inhibitor (A)</p> Signup and view all the answers

What is the primary effect of LTC4 and LTD4 on the cardiovascular system?

<p>Reduces myocardial contractility and coronary blood flow (B)</p> Signup and view all the answers

Which type of drug has been approved for therapeutic uses on the female reproductive system?

<p>Abortion inducer (A)</p> Signup and view all the answers

Which drug is used for the treatment of erectile dysfunction?

<p>Alprostadil (A)</p> Signup and view all the answers

What enzyme is responsible for the cleavage of arachidonic acid (AA) from membrane-bound phosphatidylcholine?

<p>Phospholipase A2 (B)</p> Signup and view all the answers

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