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Questions and Answers
What is the brand name of Atomoxetine?
What class of medication is Atomoxetine?
Selective norepinephrine reuptake inhibitor
What conditions is Atomoxetine commonly prescribed for?
ADHD and treatment of resistant depression
What is the mechanism of action of Atomoxetine?
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How long until Atomoxetine works? The onset of therapeutic actions in ADHD can be seen as early as the first day of dosing, therapeutic actions may continue to improve for ___ weeks.
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What symptoms does Atomoxetine target in ADHD?
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Match the following side effects of Atomoxetine:
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What are some life-threatening side effects of Atomoxetine?
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How should Atomoxetine be dosed for children less than 70kg?
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What are common overdose symptoms of Atomoxetine?
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What drug interaction associated with Atomoxetine increases the risk of seizures?
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Which medications increase plasma concentrations of Atomoxetine?
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Atomoxetine should be used with caution in patients with urinary retention and cardiovascular disease.
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Study Notes
Atomoxetine Overview
- Brand name is Strattera.
- Classified as a selective norepinephrine reuptake inhibitor (NRI).
- Commonly prescribed for ADHD and treatment-resistant depression.
Mechanism of Action
- Increases norepinephrine neurotransmission.
- May enhance dopamine levels in the prefrontal cortex.
Efficacy Timeline
- Therapeutic effects for ADHD may be observed as early as the first day of dosing.
- Continuous improvement can occur over 8-12 weeks; if ineffective after 6-8 weeks, discontinue.
Symptom Reduction
- Targets symptoms of inattentiveness, motor hyperactivity, and impulsiveness.
- Aims to improve functioning in social, academic, and occupational settings.
Side Effects
- Common side effects include increased appetite, dry mouth, insomnia, anxiety, and dizziness.
- Other effects: abdominal pain, dyspepsia, sweating, and decreased appetite.
Severe Side Effects
- Life-threatening risks include increased heart rate, hypertension, severe liver damage, and potential suicidal ideation.
Dosing Guidelines
- For children under 70 kg: Initial dose of 0.5 mg/kg/day; may increase to 1.2 mg/kg/day after 7 days. Maximum is 1.4 mg/kg/day or 100 mg, whichever is lower.
- For adults or children over 70 kg: Start with 4 mg/day; can increase to 80 mg/day after 7 days and up to 100 mg/day in 2-4 weeks.
Overdose Symptoms
- Symptoms of overdose include sedation, agitation, hyperactivity, and gastrointestinal issues.
Drug Interactions
- Tramadol may increase seizure risk when combined with antidepressants.
- Plasma concentrations may be elevated with paroxetine and fluoxetine.
Cautionary Use
- Use with caution in patients with urinary retention, benign prostatic hyperplasia (BPH), cardiovascular disease (CVD), cerebrovascular disease, hypertension, or tachycardia.
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Description
Test your knowledge on Atomoxetine with these flashcards. Covering key terms like brand name, class, and mechanism of action, this quiz is perfect for students of pharmacology or those interested in ADHD treatments. Enhance your understanding of this medication and its uses.
