Atherosclerosis and Vascular Diseases

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Questions and Answers

What is the typical degree of occlusion at which chronic occlusion limits flow in the coronary artery?

  • 60%
  • 80%
  • 70% (correct)
  • 50%

Which factor contributes to the weakening of plaque integrity, making it unable to resist vascular shear forces?

  • Increased number of smooth muscle cells
  • Presence of foam cells (correct)
  • High blood cholesterol levels
  • Reduced inflammatory cell clusters

What is the consequence of partial or complete vascular obstruction triggered by plaque erosion or rupture?

  • Tissue infarction (correct)
  • Lower plaque volume
  • Increased blood flow
  • Reduced cardiac demand

Which term is used to describe plaques that contain large numbers of foam cells and abundant extracellular lipids?

<p>Vulnerable plaques (B)</p> Signup and view all the answers

What causes chest pain in patients with stable angina during modest exertion?

<p>Normal flow at rest and increased demand during exertion (C)</p> Signup and view all the answers

Which type of plaques are at high risk of rupturing due to having thin fibrous caps with few smooth muscle cells?

<p>Vulnerable plaques (B)</p> Signup and view all the answers

Which arteries are most commonly affected by atherosclerosis?

<p>Large elastic arteries and large- to medium-sized muscular arteries (C)</p> Signup and view all the answers

What are the major clinical consequences of atherosclerosis mentioned in the text?

<p>Myocardial infarction, cerebral infarction, aortic aneurysm, and peripheral vascular disease (B)</p> Signup and view all the answers

What factors determine the principal pathophysiologic outcome of atherosclerotic lesions?

<p>The size of the affected vessel, the size and stability of the plaques, and the degree to which plaques disrupt the vessel wall (D)</p> Signup and view all the answers

What process is mentioned in the text that initially preserves the luminal diameter of the affected vessel?

<p>Remodeling of the media (C)</p> Signup and view all the answers

What happens when the limits of remodeling are reached?

<p>The atheroma begins to impinge on blood flow (B)</p> Signup and view all the answers

Which of the following is NOT a sign or symptom of atherosclerosis mentioned in the text?

<p>Pulmonary embolism (B)</p> Signup and view all the answers

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