Atherosclerosis and Pigments Accumulation Quiz
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Questions and Answers

What gives atherosclerotic plaques their characteristic yellow color?

  • Cholesterol and cholesteryl esters (correct)
  • Melanin
  • Hemosiderin
  • Lipofuscin
  • Which pigment is most commonly associated with sun tanning?

  • Melanin (correct)
  • Hemosiderin
  • Lipofuscin
  • Bilirubin
  • What is the most common inhaled pigment that is phagocytosed by alveolar macrophages?

  • Bilirubin
  • Carbon (coal dust) (correct)
  • Melanin
  • Hemosiderin
  • In which cells can exogenous pigments like carbon accumulate?

    <p>Macrophages</p> Signup and view all the answers

    What pigment acts as a screen against harmful ultraviolet radiation?

    <p>Melanin</p> Signup and view all the answers

    What are the three categories of intracellular accumulations mentioned in the text?

    <p>Normal cellular constituents, abnormal substances, and pigments</p> Signup and view all the answers

    Which of the following is not a pathway of abnormal intracellular accumulations according to the text?

    <p>Excessive degradation of phagocytosed particles</p> Signup and view all the answers

    Which condition is characterized by the accumulation of excess cholesterol within cells?

    <p>Fatty liver</p> Signup and view all the answers

    What is a common example of an exogenous pigment mentioned in the text?

    <p>Coal dust</p> Signup and view all the answers

    Which term is defined as an abnormal accumulation of iron in tissues, particularly in organs like the liver?

    <p>Hemosiderosis</p> Signup and view all the answers

    What is the major storage form of iron that accumulates in tissues when there is an excess of iron?

    <p>Hemosiderin</p> Signup and view all the answers

    Which pigment is known as the 'wear and tear' pigment, consisting of lipids and phospholipids complexed with proteins?

    <p>Lipofuscin</p> Signup and view all the answers

    Which type of iron accumulation leads to tissue damage, scarring, and organ dysfunction?

    <p>Hemochromatosis</p> Signup and view all the answers

    Which pigment can be identified unambiguously by the Prussian blue histochemical reaction?

    <p>Hemosiderin</p> Signup and view all the answers

    What is the golden-yellow to brown granular pigment that is derived from hemoglobin and can accumulate in liver cells?

    <p>Hemosiderin</p> Signup and view all the answers

    What is the term used to describe lipofuscin when it imparts an appearance to the tissue that is called brown atrophy?

    <p>Brown pigment</p> Signup and view all the answers

    What is the typical appearance of lipofuscin in tissue sections?

    <p>Perinuclear electron-dense granules</p> Signup and view all the answers

    Which of the following tissues is lipofuscin NOT commonly seen in?

    <p>Kidney</p> Signup and view all the answers

    What forms the abnormal deposition of calcium salts seen in pathologic calcification?

    <p>Calcium salts with other minerals such as iron and magnesium</p> Signup and view all the answers

    In which condition does dystrophic calcification occur?

    <p>Degenerated or dead tissues with normal serum calcium levels</p> Signup and view all the answers

    What is the term used to describe the abnormal accumulation of triglycerides within parenchymal cells?

    <p>Steatosis</p> Signup and view all the answers

    Which of the following is a condition that may result in the accumulation of proteins within cells due to defects in folding and transport?

    <p>α1-antitrypsin deficiency</p> Signup and view all the answers

    In which of the following conditions does an abnormal exogenous substance accumulate because the cell lacks the enzymatic machinery to degrade it?

    <p>Anthracosis</p> Signup and view all the answers

    Which of the following substances may accumulate due to an inherited defect in an enzyme responsible for its degradation?

    <p>Glycogen</p> Signup and view all the answers

    What type of change involves abnormal accumulation of minerals like iron or carbon within cells?

    <p>Pigment accumulation</p> Signup and view all the answers

    What is the consequence of parathyroid hormone excess on serum calcium levels?

    <p>Hypercalcemia</p> Signup and view all the answers

    Where does metastatic calcification primarily occur due to increased secretion of parathyroid hormone?

    <p>Kidneys</p> Signup and view all the answers

    Which condition is NOT a cause of metastatic calcification?

    <p>Anemia</p> Signup and view all the answers

    In which disease is metastatic calcification associated with renal failure as a cause of secondary hyperparathyroidism?

    <p>Renal failure</p> Signup and view all the answers

    What is the principle cause of metastatic calcification related to destruction of bone tissue?

    <p>Multiple myeloma</p> Signup and view all the answers

    What is the major cause of fatty liver?

    <p>Alcoholic liver disease</p> Signup and view all the answers

    How does protein malnutrition contribute to lipid accumulation in the liver?

    <p>By disrupting mitochondria and SER</p> Signup and view all the answers

    Which organ is commonly affected by fatty change?

    <p>Liver</p> Signup and view all the answers

    What morphological changes are observed in a severe fatty liver?

    <p>Enlarged, yellow, and greasy liver</p> Signup and view all the answers

    What distinguishes lipid accumulations from water or glycogen accumulations in the liver?

    <p>Special preparation and stain</p> Signup and view all the answers

    Which condition is associated with cholesterol and cholesterol esters accumulation?

    <p>Atherosclerosis</p> Signup and view all the answers

    How do exogenous pigments like carbon accumulate in cells?

    <p>By phagocytosis</p> Signup and view all the answers

    What is the effect of hepatotoxins like alcohol on lipid accumulation in the liver?

    <p>Disrupt mitochondria and SER</p> Signup and view all the answers

    What is the consequence of severe fatty change in the liver?

    <p>Cell death</p> Signup and view all the answers

    What can disrupt the steps of uptake, catabolism, or secretion leading to lipid accumulation?

    <p>Toxins</p> Signup and view all the answers

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