Atherosclerosis and Pigments Accumulation Quiz

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Questions and Answers

What gives atherosclerotic plaques their characteristic yellow color?

  • Cholesterol and cholesteryl esters (correct)
  • Melanin
  • Hemosiderin
  • Lipofuscin

Which pigment is most commonly associated with sun tanning?

  • Melanin (correct)
  • Hemosiderin
  • Lipofuscin
  • Bilirubin

What is the most common inhaled pigment that is phagocytosed by alveolar macrophages?

  • Bilirubin
  • Carbon (coal dust) (correct)
  • Melanin
  • Hemosiderin

In which cells can exogenous pigments like carbon accumulate?

<p>Macrophages (B)</p> Signup and view all the answers

What pigment acts as a screen against harmful ultraviolet radiation?

<p>Melanin (D)</p> Signup and view all the answers

What are the three categories of intracellular accumulations mentioned in the text?

<p>Normal cellular constituents, abnormal substances, and pigments (A)</p> Signup and view all the answers

Which of the following is not a pathway of abnormal intracellular accumulations according to the text?

<p>Excessive degradation of phagocytosed particles (C)</p> Signup and view all the answers

Which condition is characterized by the accumulation of excess cholesterol within cells?

<p>Fatty liver (C)</p> Signup and view all the answers

What is a common example of an exogenous pigment mentioned in the text?

<p>Coal dust (C)</p> Signup and view all the answers

Which term is defined as an abnormal accumulation of iron in tissues, particularly in organs like the liver?

<p>Hemosiderosis (C)</p> Signup and view all the answers

What is the major storage form of iron that accumulates in tissues when there is an excess of iron?

<p>Hemosiderin (B)</p> Signup and view all the answers

Which pigment is known as the 'wear and tear' pigment, consisting of lipids and phospholipids complexed with proteins?

<p>Lipofuscin (C)</p> Signup and view all the answers

Which type of iron accumulation leads to tissue damage, scarring, and organ dysfunction?

<p>Hemochromatosis (A)</p> Signup and view all the answers

Which pigment can be identified unambiguously by the Prussian blue histochemical reaction?

<p>Hemosiderin (A)</p> Signup and view all the answers

What is the golden-yellow to brown granular pigment that is derived from hemoglobin and can accumulate in liver cells?

<p>Hemosiderin (D)</p> Signup and view all the answers

What is the term used to describe lipofuscin when it imparts an appearance to the tissue that is called brown atrophy?

<p>Brown pigment (B)</p> Signup and view all the answers

What is the typical appearance of lipofuscin in tissue sections?

<p>Perinuclear electron-dense granules (B)</p> Signup and view all the answers

Which of the following tissues is lipofuscin NOT commonly seen in?

<p>Kidney (D)</p> Signup and view all the answers

What forms the abnormal deposition of calcium salts seen in pathologic calcification?

<p>Calcium salts with other minerals such as iron and magnesium (D)</p> Signup and view all the answers

In which condition does dystrophic calcification occur?

<p>Degenerated or dead tissues with normal serum calcium levels (C)</p> Signup and view all the answers

What is the term used to describe the abnormal accumulation of triglycerides within parenchymal cells?

<p>Steatosis (B)</p> Signup and view all the answers

Which of the following is a condition that may result in the accumulation of proteins within cells due to defects in folding and transport?

<p>α1-antitrypsin deficiency (D)</p> Signup and view all the answers

In which of the following conditions does an abnormal exogenous substance accumulate because the cell lacks the enzymatic machinery to degrade it?

<p>Anthracosis (D)</p> Signup and view all the answers

Which of the following substances may accumulate due to an inherited defect in an enzyme responsible for its degradation?

<p>Glycogen (B)</p> Signup and view all the answers

What type of change involves abnormal accumulation of minerals like iron or carbon within cells?

<p>Pigment accumulation (D)</p> Signup and view all the answers

What is the consequence of parathyroid hormone excess on serum calcium levels?

<p>Hypercalcemia (A)</p> Signup and view all the answers

Where does metastatic calcification primarily occur due to increased secretion of parathyroid hormone?

<p>Kidneys (C)</p> Signup and view all the answers

Which condition is NOT a cause of metastatic calcification?

<p>Anemia (A)</p> Signup and view all the answers

In which disease is metastatic calcification associated with renal failure as a cause of secondary hyperparathyroidism?

<p>Renal failure (C)</p> Signup and view all the answers

What is the principle cause of metastatic calcification related to destruction of bone tissue?

<p>Multiple myeloma (B)</p> Signup and view all the answers

What is the major cause of fatty liver?

<p>Alcoholic liver disease (B)</p> Signup and view all the answers

How does protein malnutrition contribute to lipid accumulation in the liver?

<p>By disrupting mitochondria and SER (D)</p> Signup and view all the answers

Which organ is commonly affected by fatty change?

<p>Liver (A)</p> Signup and view all the answers

What morphological changes are observed in a severe fatty liver?

<p>Enlarged, yellow, and greasy liver (D)</p> Signup and view all the answers

What distinguishes lipid accumulations from water or glycogen accumulations in the liver?

<p>Special preparation and stain (D)</p> Signup and view all the answers

Which condition is associated with cholesterol and cholesterol esters accumulation?

<p>Atherosclerosis (C)</p> Signup and view all the answers

How do exogenous pigments like carbon accumulate in cells?

<p>By phagocytosis (A)</p> Signup and view all the answers

What is the effect of hepatotoxins like alcohol on lipid accumulation in the liver?

<p>Disrupt mitochondria and SER (D)</p> Signup and view all the answers

What is the consequence of severe fatty change in the liver?

<p>Cell death (B)</p> Signup and view all the answers

What can disrupt the steps of uptake, catabolism, or secretion leading to lipid accumulation?

<p>Toxins (B)</p> Signup and view all the answers

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