Podcast
Questions and Answers
Which lipoprotein is mostly free cholesterol?
Which lipoprotein is mostly free cholesterol?
- LDL (correct)
- TAG
- VLDL
- HDL
What is a key element for cholesterol homeostasis?
What is a key element for cholesterol homeostasis?
- Cholesterol deposition in blood vessel walls
- Deposition of free cholesterol
- Balance between LDL and HDL cholesterol carriers (correct)
- Increased narrowing of blood vessel lumens
What characteristic differentiates HDL from LDL?
What characteristic differentiates HDL from LDL?
- Higher TAG levels in HDL than in LDL
- Lower phospholipids in LDL compared to HDL
- Higher protein content in LDL than in HDL (correct)
- More free cholesterol in HDL than in LDL
What does LDL stand for in the context of cholesterol transport?
What does LDL stand for in the context of cholesterol transport?
What results from an imbalance between LDL and HDL carriers in cholesterol homeostasis?
What results from an imbalance between LDL and HDL carriers in cholesterol homeostasis?
What is the main function of HDL in cholesterol homeostasis?
What is the main function of HDL in cholesterol homeostasis?
What is the main function of VLDLs compared to LDLs?
What is the main function of VLDLs compared to LDLs?
Which protein is recognized by apo B-100 during LDL metabolism?
Which protein is recognized by apo B-100 during LDL metabolism?
Where does PCSK9 undergo autocatalytic cleavage?
Where does PCSK9 undergo autocatalytic cleavage?
What is the fate of the complex formed by LDL-C, LDLR, and PCSK9 after internalization into hepatocytes?
What is the fate of the complex formed by LDL-C, LDLR, and PCSK9 after internalization into hepatocytes?
At which cellular site does PCSK9 target LDLRs for degradation?
At which cellular site does PCSK9 target LDLRs for degradation?
How does PCSK9 prevent the recycling of LDLRs from the endosome back to the cell surface?
How does PCSK9 prevent the recycling of LDLRs from the endosome back to the cell surface?
What is the function of HDL in relation to cholesterol?
What is the function of HDL in relation to cholesterol?
Which apoprotein is required for receptor-mediated endocytosis of IDLs and chylomicron remnants?
Which apoprotein is required for receptor-mediated endocytosis of IDLs and chylomicron remnants?
What is the primary composition of nascent HDL particles?
What is the primary composition of nascent HDL particles?
What activates Lipoprotein Lipase (LPL) for the hydrolysis of triglycerides in VLDL and chylomicrons?
What activates Lipoprotein Lipase (LPL) for the hydrolysis of triglycerides in VLDL and chylomicrons?
What is the role of mature HDL (HDL2) in handling cholesterol?
What is the role of mature HDL (HDL2) in handling cholesterol?
Which step comes first in the Reverse cholesterol transport by HDL process?
Which step comes first in the Reverse cholesterol transport by HDL process?
Which drug inhibits the microsomal triglyceride transfer protein (MTP) to lower production in the liver and release of LDL cholesterol in the blood?
Which drug inhibits the microsomal triglyceride transfer protein (MTP) to lower production in the liver and release of LDL cholesterol in the blood?
Which drug blocks the protein in the liver called proprotein convertase subtilisin kexin 9 (PCSK9) to help the body get rid of LDL cholesterol from the blood?
Which drug blocks the protein in the liver called proprotein convertase subtilisin kexin 9 (PCSK9) to help the body get rid of LDL cholesterol from the blood?
Which drug was recently approved by the FDA for young children with a rare form of high cholesterol?
Which drug was recently approved by the FDA for young children with a rare form of high cholesterol?
Which drug is an adenosine triphosphate-citrate lyase inhibitor that helps stop cholesterol production in your liver?
Which drug is an adenosine triphosphate-citrate lyase inhibitor that helps stop cholesterol production in your liver?
Which drug blocks production of the PCSK9 protein in the liver to lower LDL cholesterol levels?
Which drug blocks production of the PCSK9 protein in the liver to lower LDL cholesterol levels?
Which drug was recently approved by the FDA as a combination therapy of bempedoic acid and ezetimibe for treating hypercholesterolemia?
Which drug was recently approved by the FDA as a combination therapy of bempedoic acid and ezetimibe for treating hypercholesterolemia?
What is the dosage of the recently FDA-approved medication?
What is the dosage of the recently FDA-approved medication?
How often should the initial dose of the medication be repeated?
How often should the initial dose of the medication be repeated?
After the initial repeat, how often should the medication be administered thereafter?
After the initial repeat, how often should the medication be administered thereafter?
Which reference discusses the molecular biology of PCSK9 and its role in LDL metabolism?
Which reference discusses the molecular biology of PCSK9 and its role in LDL metabolism?
Which reference discusses Angiopoietin-Like 3 (ANGPTL3) and its effects on atherosclerosis?
Which reference discusses Angiopoietin-Like 3 (ANGPTL3) and its effects on atherosclerosis?
What is the purpose of the provided anonymous questionnaire and knowledge assessment?
What is the purpose of the provided anonymous questionnaire and knowledge assessment?
