Assessment of Lipid Profile Knowledge Quiz
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Questions and Answers

Which lipoprotein is mostly free cholesterol?

  • LDL (correct)
  • TAG
  • VLDL
  • HDL
  • What is a key element for cholesterol homeostasis?

  • Cholesterol deposition in blood vessel walls
  • Deposition of free cholesterol
  • Balance between LDL and HDL cholesterol carriers (correct)
  • Increased narrowing of blood vessel lumens
  • What characteristic differentiates HDL from LDL?

  • Higher TAG levels in HDL than in LDL
  • Lower phospholipids in LDL compared to HDL
  • Higher protein content in LDL than in HDL (correct)
  • More free cholesterol in HDL than in LDL
  • What does LDL stand for in the context of cholesterol transport?

    <p>Low Density Lipoproteins</p> Signup and view all the answers

    What results from an imbalance between LDL and HDL carriers in cholesterol homeostasis?

    <p>Cholesterol deposition in blood vessel walls</p> Signup and view all the answers

    What is the main function of HDL in cholesterol homeostasis?

    <p>Reverse cholesterol transport from tissues to liver</p> Signup and view all the answers

    What is the main function of VLDLs compared to LDLs?

    <p>Transport cholesterol from liver to peripheral tissues</p> Signup and view all the answers

    Which protein is recognized by apo B-100 during LDL metabolism?

    <p>LDLR</p> Signup and view all the answers

    Where does PCSK9 undergo autocatalytic cleavage?

    <p>Endoplasmic reticulum</p> Signup and view all the answers

    What is the fate of the complex formed by LDL-C, LDLR, and PCSK9 after internalization into hepatocytes?

    <p>Lysosomal degradation</p> Signup and view all the answers

    At which cellular site does PCSK9 target LDLRs for degradation?

    <p>Golgi apparatus</p> Signup and view all the answers

    How does PCSK9 prevent the recycling of LDLRs from the endosome back to the cell surface?

    <p>By directing receptors to lysosomes</p> Signup and view all the answers

    What is the function of HDL in relation to cholesterol?

    <p>Uptake of cholesterol</p> Signup and view all the answers

    Which apoprotein is required for receptor-mediated endocytosis of IDLs and chylomicron remnants?

    <p>Apo E</p> Signup and view all the answers

    What is the primary composition of nascent HDL particles?

    <p>Contains primarily phospholipid (PC)</p> Signup and view all the answers

    What activates Lipoprotein Lipase (LPL) for the hydrolysis of triglycerides in VLDL and chylomicrons?

    <p>Apo C-II</p> Signup and view all the answers

    What is the role of mature HDL (HDL2) in handling cholesterol?

    <p>Collection of cholesterol</p> Signup and view all the answers

    Which step comes first in the Reverse cholesterol transport by HDL process?

    <p>Efflux of cholesterol from peripheral tissues to HDL3</p> Signup and view all the answers

    Which drug inhibits the microsomal triglyceride transfer protein (MTP) to lower production in the liver and release of LDL cholesterol in the blood?

    <p>Lomitapide</p> Signup and view all the answers

    Which drug blocks the protein in the liver called proprotein convertase subtilisin kexin 9 (PCSK9) to help the body get rid of LDL cholesterol from the blood?

    <p>PCSK9 inhibitors</p> Signup and view all the answers

    Which drug was recently approved by the FDA for young children with a rare form of high cholesterol?

    <p>Evinacumab</p> Signup and view all the answers

    Which drug is an adenosine triphosphate-citrate lyase inhibitor that helps stop cholesterol production in your liver?

    <p>Bempedoic acid</p> Signup and view all the answers

    Which drug blocks production of the PCSK9 protein in the liver to lower LDL cholesterol levels?

    <p>Inclisiran</p> Signup and view all the answers

    Which drug was recently approved by the FDA as a combination therapy of bempedoic acid and ezetimibe for treating hypercholesterolemia?

    <p>Bempedoic acid and ezetimibe</p> Signup and view all the answers

    What is the dosage of the recently FDA-approved medication?

    <p>284mg/1.5mL (prefilled syringe) SC</p> Signup and view all the answers

    How often should the initial dose of the medication be repeated?

    <p>Initially, repeat in 3 months</p> Signup and view all the answers

    After the initial repeat, how often should the medication be administered thereafter?

    <p>Every 6 months</p> Signup and view all the answers

    Which reference discusses the molecular biology of PCSK9 and its role in LDL metabolism?

    <p>Molecular biology of PCSK9: its role in LDL metabolism</p> Signup and view all the answers

    Which reference discusses Angiopoietin-Like 3 (ANGPTL3) and its effects on atherosclerosis?

    <p>Angiopoietin-Like 3 (ANGPTL3) and Atherosclerosis: Lipid and Non-Lipid Related Effects</p> Signup and view all the answers

    What is the purpose of the provided anonymous questionnaire and knowledge assessment?

    <p>To assess the current knowledge of the user on the topic</p> Signup and view all the answers

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