Assay of Ibuprofen Tablets

Study Notes

Ibuprofen and NSAIDs

Ibuprofen is a non-steroidal anti-inflammatory agent (NSAID), also known as Isobutylphenylpropionic acid.
Other examples of NSAIDs include Aspirin, Naprosyn, Diclofenac, and Celecoxib.

Assay of Ibuprofen Tablets

The assay involves three steps: Uniformity of weight test, Standardization of 0.1 M NaOH, and Assay of Ibuprofen tablets.

Uniformity of Weight Test

Determine the weight of the tablet/powder that contains a specific mass of the API (Ibuprofen).
Steps involved:
- Weigh 20 tablets together and determine the average weight.
- Weigh 20 tablets individually.
- Calculate the deviation of the individual weight from the average weight.

Standardization of 0.1 M NaOH Solution

Involves three steps:
- Standardization of 0.1 M HCl.
- Standardization of 0.05 M H2SO4.
- Using Sulphamic acid (H3NSO3).

Assay of Ibuprofen using 0.1 M NaOH Solution

Transfer a quantity of the powder containing 0.450 g of ibuprofen to a sintered-glass crucible.
Extract with five 10 mL quantities of methanol R.
Add 0.4 mL of phenolphthalein solution R1.
Titrate with 0.1 M sodium hydroxide until a red color is obtained.
Perform a blank titration.

Determination of % Content

Assuming the sample was obtained from a tablet.
An equivalent weight would have been taken (y g).
Weight obtained from assay is x g.
% content is calculated using these values.

Considerations for Titrations

Three burette readings are required and must not be more than 0.05 mL apart from each other for both standardization and assay of sulphanilamide.
Precautions:
- Appropriate burette reading.
- Good pipetting and solution transfer skills.
- Avoid spilling of reagents.
- Ensure proper mixing of all solutions.

Description

This quiz covers the steps involved in the assay of Ibuprofen tablets, including the uniformity of weight test and standardization of 0.1 M NaOH. It also reviews other non-steroidal anti-inflammatory agents (NSAIDs) such as Aspirin, Naprosyn, Diclofenac, and Celecoxib.