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Questions and Answers
What is the characteristic of Grade I ascites?
What is the characteristic of Grade I ascites?
What physical examination finding is associated with Grade II ascites?
What physical examination finding is associated with Grade II ascites?
Which of the following is NOT part of the initial evaluation for newly discovered ascites?
Which of the following is NOT part of the initial evaluation for newly discovered ascites?
What describes Grade III ascites?
What describes Grade III ascites?
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Which laboratory tests are included in the initial assessment of ascites?
Which laboratory tests are included in the initial assessment of ascites?
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In which of the following situations is a diagnostic paracentesis indicated?
In which of the following situations is a diagnostic paracentesis indicated?
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What is the primary reason for performing a diagnostic paracentesis in patients with ascites?
What is the primary reason for performing a diagnostic paracentesis in patients with ascites?
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Which grade of ascites warrants a diagnostic paracentesis upon new onset?
Which grade of ascites warrants a diagnostic paracentesis upon new onset?
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Which of the following groups of patients should definitely receive a diagnostic paracentesis?
Which of the following groups of patients should definitely receive a diagnostic paracentesis?
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Which condition is NOT an indication for performing a diagnostic paracentesis?
Which condition is NOT an indication for performing a diagnostic paracentesis?
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What does a serum-ascites albumin gradient (SAAG) greater than 1.1 indicate?
What does a serum-ascites albumin gradient (SAAG) greater than 1.1 indicate?
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Which total protein level in ascitic fluid is suggestive of cirrhotic ascites?
Which total protein level in ascitic fluid is suggestive of cirrhotic ascites?
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Which condition is NOT indicated by a SAAG measurement of less than or equal to 1.1?
Which condition is NOT indicated by a SAAG measurement of less than or equal to 1.1?
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What is the significance of the difference in albumin concentration between serum and ascitic fluid?
What is the significance of the difference in albumin concentration between serum and ascitic fluid?
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A patient presents with ascites and a SAAG of 1.0. What does this likely suggest?
A patient presents with ascites and a SAAG of 1.0. What does this likely suggest?
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What is the recommended sodium intake for managing Grade II Ascites?
What is the recommended sodium intake for managing Grade II Ascites?
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Which dietary approach is advised for individuals managing Grade II Ascites?
Which dietary approach is advised for individuals managing Grade II Ascites?
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What level of salt restriction is indicated for effective management of ascites?
What level of salt restriction is indicated for effective management of ascites?
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Why is it important to avoid pre-prepared meals for individuals with Grade II Ascites?
Why is it important to avoid pre-prepared meals for individuals with Grade II Ascites?
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Which of the following statements about salt restriction in ascites is true?
Which of the following statements about salt restriction in ascites is true?
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What condition necessitates the discontinuation of all diuretics?
What condition necessitates the discontinuation of all diuretics?
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In which patient situation should diuretics be maintained despite severe hyponatremia?
In which patient situation should diuretics be maintained despite severe hyponatremia?
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Which of the following is NOT a common etiology of acute liver failure (ALF)?
Which of the following is NOT a common etiology of acute liver failure (ALF)?
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What is a critical serum sodium concentration threshold that indicates severe hyponatremia?
What is a critical serum sodium concentration threshold that indicates severe hyponatremia?
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Which time frame is significant for considering the discontinuation of diuretics in patients with acute liver failure?
Which time frame is significant for considering the discontinuation of diuretics in patients with acute liver failure?
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Which viral hepatitis is primarily transmitted via fecal-oral route?
Which viral hepatitis is primarily transmitted via fecal-oral route?
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Which condition is characterized by the obstruction of hepatic venous outflow?
Which condition is characterized by the obstruction of hepatic venous outflow?
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Which syndrome is specifically associated with pregnancy and involves hepatic dysfunction?
Which syndrome is specifically associated with pregnancy and involves hepatic dysfunction?
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Which types of hepatitis are classified as autoimmune conditions?
Which types of hepatitis are classified as autoimmune conditions?
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Which of the following conditions is considered a secondary cause of hepatitis?
Which of the following conditions is considered a secondary cause of hepatitis?
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Study Notes
Management of Cirrhotic Ascites and its Complications
- Ascites is the most common complication of cirrhosis.
- 60% of compensated cirrhosis patients develop ascites within 10 years.
- Ascites development signifies a poor prognosis and impairs quality of life.
- Two types of ascites: uncomplicated and complicated.
- Complicated ascites are associated with poor prognosis.
Definition of Ascites
- Pathological accumulation of fluid within the peritoneal cavity.
Pathogenesis of Ascites in Cirrhosis
- Portal hypertension
- Vasodilator factors (NO, endocannabinoids, CO).
- Splanchnic arterial vasodilatation.
- Abnormal distribution of blood volume.
- Reduced effective arterial blood volume.
- Stimulation of antinatriuretic/vasoconstrictor systems.
- Increased tubular sodium reabsorption.
- Positive sodium balance.
- Sodium and fluid retention.
Grading of Ascites
- Grade I: Only detectable by ultrasound (USS).
- Grade II: Moderate symmetrical abdominal enlargement—shifting dullness.
- Grade III: Marked abdominal enlargement—transmitted thrill.
Initial Evaluation of Ascites
- Thorough history taking.
- Physical examination.
- Abdominal ultrasound (USS).
- Liver function tests (LFTS).
- Urea, creatinine, and serum electrolytes.
- Diagnostic paracentesis for Grade 2 or 3 ascites, and for worsening ascites or cirrhosis complications.
Paracentesis and Ascites Workup
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Routine tests: Ascitic fluid cell count, protein, and albumin levels.
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Serum ascites albumin gradient (SAAG): Serum albumin concentration minus ascitic fluid albumin concentration.
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SAAG > 1.1: Indicates portal hypertension-related ascites.
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Total protein < 2.5 g/dL: Suggests cirrhotic ascites.
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Total protein ≥ 2.5 g/dL: Suggests cardiac ascites (congestive heart failure, constrictive pericarditis), or Budd-Chiari syndrome
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SAAG < 1.1: Indicates non-portal hypertension-related ascites
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Total protein < 2.5 g/dL: Suggests nephrotic ascites.
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Total protein ≥ 2.5 g/dL: Suggests peritoneal carcinomatosis, tuberculous ascites, or other conditions.
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Polymorphonuclear (PMN) leukocyte count ≥ 250 cells/mm³ indicates infection, often spontaneous bacterial peritonitis (SBP).
Diagnostic Paracentesis
- Determining presence and progression of ascites associated with certain causes, such as cirrhosis.
Grade II Ascites Treatment
- Salt restriction: 80-120 mmol sodium/day.
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Diuretics (Spironolactone +/– Furosemide): Treatment of choice, focuses on negative sodium balance.
- Starting dose: 100 mg/day spironolactone. Increasing dose (100 mg steps) until response.
- Furosemide is added if the aldosterone antagonist is insufficient (40 mg/day increase, max 160 mg/day).
- Fluid Restriction: Only needed if serum sodium is abnormal.
Grade III Ascites Treatment
- Large volume paracentesis (LVP): 5 liters of ascitic fluid at one session (treatment of choice).
- Albumin administration: Prevents post-paracentesis circulatory dysfunction and prevents re-accumulation.
Refractory Ascites
- Ascites not responding to medical treatment.
- Median survival of patients with refractory ascites is approximately 6 months.
- Liver transplantation should be considered if medical management fails.
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Common causes: SBP, HRS, severe hyponatremia, portal vein thrombosis (PVT), hepatocellular carcinoma (HCC).
- Diuretic-resistant ascites: poor response to sodium restriction and diuretic treatment
- Diuretic-intractable ascites: response to treatment is further blocked by induced complications
Diagnostic Criteria for Refractory Ascites
- Intensive diuretic therapy (spironolactone 400 mg/day + furosemide 160 mg/day) with a low-sodium diet (<90 mmol/day) for at least 1 week.
- < 0.8 kg weight loss over 4 days.
- Reappearance of grade 2 or 3 ascites within 4 weeks of initial mobilization.
- Diuretic-induced encephalopathy absence of other precipitating factors.
- Renal impairment
- Hypo/hyperkalemia: despite appropriate measures
- Hyponatremia
Treatment Options for Refractory Ascites
- LVP plus albumin: Not effective or inducing complications in >90% of patients.
- TIPSS (Transjugular Intrahepatic Portosystemic Shunt): Considered with frequent or large-volume paracentesis.
- Liver Transplantation: Treatment of choice for refractory ascites
Spontaneous Bacterial Peritonitis (SBP)
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Diagnosis: Paracentesis is essential in all patients.
- Critical assessment: of all high-risk patients with cirrhosis and ascites is encouraged
- Treatment: Third-generation cephalosporins (first-line treatment).
- Prophylaxis: High-risk groups (acute gastrointestinal hemorrhage, low total protein in ascites, prior history of SBP)
Hepatorenal Syndrome (HRS)
- Renal dysfunction in advanced liver disease without other causes.
- Diagnostic criteria crucial for early recognition and treatment
- Treatment of possible causes must be performed before HRS diagnosis
- Treatment: Albumin infusion, antibiotics for SBP
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Sepsis screen: Early identification of bacterial infection (blood, urine, and ascitic fluid cultures).
- Maintain prophylactic antibiotics (if prescribed) in patients without signs of infection
HRS types and their criteria (Old and New Classification):
- There are new and old classifications for HRS types with different criteria and their definitions.
Hepatic Encephalopathy (HE)
- Brain dysfunction caused by liver and/or portal-systemic insufficiency.
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Pathogenesis: Ammonium accumulation.
- Abnormal neurotransmission. Alterations in permeability of Blood brain barrier.
- Classification: Varies from minimal to coma.
- Grading: Grades 0-4 based on clinical abnormalities.
- Diagnosis: Exclusion of other causes of encephalopathy.
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Precipitating factors
- Several factors may influence the severity
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Treatment:
- Treat the precipitating factor alongside supportive measures
- Lactulose, rifaximin, L-ornithine L-aspartate (LOOA), and other medications.
Acute Liver Failure (ALF)
- Severe liver injury, coagulopathy (INR >1.5), and encephalopathy within 26 weeks.
- Etiologies: Viral hepatitis, drug-induced injury, autoimmune hepatitis, vascular causes, and others.
- Clinical features: Often begins with malaise, nausea, jaundice, abdominal pain, and pruritus. Can demonstrate stigmata of chronic liver disease and physical findings
- Investigations (LAB): CBC, renal, hepatic panels, INR, arterial blood gases, serum lactate, viral serologies, autoimmune antibodies.
- Investigations (Imaging): Ultrasound, Doppler, MRI/CT, head CT.
- Treatment: ICU admission, supportive care (treat precipitating factors, manage fluid and electrolyte disturbances) and liver transplantation.
- Management considerations for pre-procedure treatments
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- Coagulopathy and thrombocytopenia: Treatment only when bleeding is present or prior to procedures.
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- GI bleeding: PPI for prophylaxis
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- Refractory hypotension: Vasopressors (norepinephrine)
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Description
Test your knowledge on the characteristics, evaluation, and management of ascites. This quiz covers topics such as grading of ascites, diagnostic procedures, and lab tests related to ascitic fluid. Perfect for medical students and healthcare professionals alike.