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Questions and Answers
Which of the following is a characteristic of arenaviruses?
Which of the following is a characteristic of arenaviruses?
- Pleomorphic shape (correct)
- Enveloped structure
- Monosegmented genomic organization
- Double-stranded RNA
Which of the following is a characteristic of filoviruses?
Which of the following is a characteristic of filoviruses?
- Non-enveloped structure
- Double-stranded DNA
- Ambisense genomic organization (correct)
- Monosegmented genomic organization
What is the mode of transmission for arenaviruses?
What is the mode of transmission for arenaviruses?
- Sexual contact
- Fecal-oral
- Airborne
- Vector-borne (correct)
What is the mode of transmission for filoviruses?
What is the mode of transmission for filoviruses?
Which of the following is a virulence factor found in both filoviruses and arenaviruses?
Which of the following is a virulence factor found in both filoviruses and arenaviruses?
Which virus is associated with lymphocytic choriomeningitis?
Which virus is associated with lymphocytic choriomeningitis?
Which of the following is NOT a technique used to diagnose filovirus and arenavirus infections?
Which of the following is NOT a technique used to diagnose filovirus and arenavirus infections?
Which virus is responsible for causing Lassa fever?
Which virus is responsible for causing Lassa fever?
How is Lassa fever primarily transmitted?
How is Lassa fever primarily transmitted?
Which protein is responsible for viral cellular entry of arenaviruses?
Which protein is responsible for viral cellular entry of arenaviruses?
What is the genomic composition of Lassa virus?
What is the genomic composition of Lassa virus?
Which receptor does Ebola virus use to enter cells?
Which receptor does Ebola virus use to enter cells?
Which virus causes hemorrhagic fever and has a filamentous shape?
Which virus causes hemorrhagic fever and has a filamentous shape?
Which animal is the natural host of Lassa virus?
Which animal is the natural host of Lassa virus?
Which region is Lassa fever endemic to?
Which region is Lassa fever endemic to?
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Study Notes
Characteristics of Viruses
- Arenaviruses are characterized by being negative-sense RNA viruses
- Filoviruses are characterized by being filamentous and containing a negative-sense RNA genome
Mode of Transmission
- Arenaviruses are primarily transmitted through contact with infected rodents or their urine, feces, or saliva
- Filoviruses are primarily transmitted through contact with infected bodily fluids, such as blood, sweat, and semen
Virulence Factors
- The glycoprotein (GP) is a virulence factor found in both filoviruses and arenaviruses
Virus Associations
- Lymphocytic choriomeningitis is associated with the LCMV virus, which is an arenavirus
- Lassa fever is caused by the Lassa virus, which is an arenavirus
- Ebola virus is a filovirus
Diagnosis
- Immunofluorescence assay is a technique used to diagnose filovirus and arenavirus infections
- Western blot is a technique used to diagnose filovirus and arenavirus infections
- PCR (Polymerase Chain Reaction) is a technique used to diagnose filovirus and arenavirus infections
- Gram staining is NOT a technique used to diagnose filovirus and arenavirus infections
Viral Entry and Genomics
- The SSP (stable signal peptide) is responsible for viral cellular entry of arenaviruses
- Lassa virus has a single-stranded negative-sense RNA genome
- Ebola virus uses the receptor NPC1 (Niemann-Pick disease type C1) to enter cells
Lassa Fever
- Lassa fever is primarily transmitted through contact with infected rodents or their urine, feces, or saliva
- The Mastomys natalensis is the natural host of Lassa virus
- Lassa fever is endemic to West Africa
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